Yu Leo Lei, D.D.S., Ph.D.
Department of Head and Neck Surgery, Division of Surgery
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Professor (Joint appointment), Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Professor (Joint appointment), Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Professor, Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Professor, Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
Clinical Interests
I am a board-certified Oral and Maxillofacial Pathologists. I provide histologic and molecular diagnoses for oral premalignant lesions, oral autoimmune conditions, oral cancers, and odontogenic lesions. I specialize in the clinical diagnosis and management of complex oral mucosal conditions, such as oral potentially malignant disorders (OPMD), oral lichen planus, benign membrane pemphigoid, pemphigus, oral involvement of graft-versus-host disease, and cancer treatment-associated oral mucositis.
Education & Training
Degree-Granting Education
| 2011 | University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, US, Immunology, Ph.D |
| 2006 | West China School of Stomatology, Sichuan University, Chengdu, CN, Dentistry, DDS |
Postgraduate Training
| 2014-2014 | Postdoctoral Fellow, Head and Neck Oncology Research, University of Pittsburgh, Pittsburgh, Pennsylvania |
| 2011-2014 | Residency, Oral and Maxillofacial Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania |
| 2011-2011 | Postdoctoral Fellow, Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina |
Licenses & Certifications
| 2024 | Practitioner Controlled Substance Registration |
| 2024 | Researcher Controlled Substance/Chemical Registration |
| 2022 | Full Dentist License |
| 2022 | State of Michigan Board of Dentistry |
| 2022 | State of Michigan, Controlled Substance License |
| 2015 | American Heart Association - Basic Life Support |
| 2015 | State of Michigan, Clinical Academic Dental |
| 2014 | American Board of Oral and Maxillofacial Pathology |
Experience & Service
Faculty Academic Appointments
Associate Professor, Department of Otolaryngology–Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI, 2021 - 2024
Associate Professor, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, 2021 - 2024
Adjunct Assistant Professor, Department of Otolaryngology–Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI, 2016 - 2021
Assistant Professor, Department of Periodontics and Oral Medicine, University of Michigan - Ann Arbor, Ann Arbor, MI, 2015 - 2021
Administrative Appointments/Responsibilities
Faculty Interviewer, University of Michigan Rackham Graduate School, Ann Arbor, Michigan, 2018 - 2024
Office of Research Site Visit Host, University of Michigan School of Dentistry, Ann Arbor, Michigan, 2018
Participating faculty member of the first Asian/Pacific Islander Graduation Ceremony, University of Michigan Office of Academic Multicultural Initiatives, Michigan Union, Michigan, 2018
Other Professional Positions
Key Opinion Leader Advisory Board Member, Brooklyn ImmunoTherapeutics, New York, NY, 2021 - 2022
Scientific Advisory Board Member, Saros Therapeutics, Ann Arbor, MI, 2021 - Present
Co-Founder, Saros Therapeutics, Ann Arbor, MI, 2021 - Present
Editorial Activities
Editorial Board Member, Journal of Dental Research, 2020 - Present
Editorial Board Member, Frontiers In Immunology, 2018 - Present
Editorial Board Member, Head and Neck Pathology, 2017 - 2020
Editorial Board Member, Oral Surgery Oral Medicine Oral Pathology Oral Radiology, 2014 - Present
Editorial Board Member, Journal of International Dental and Medical Research, 2011 - Present
Honors & Awards
| 2026 | Keynote Speaker, Clinical and Scientific Innovations, American Association of Oral and Maxillofacial Surgeons |
| 2025 | Meet-the-Expert and Mentor, Society for Immunotherapy of Cancer (SITC) |
| 2024 | NCI-Sponsored Travel Award (Mentor; Awardee: Hulya F. Taner), Cancer Moonshot Immuno-Oncology Translational Network Capstone Meeting, Bethesda, MD |
| 2024 | Meet-the-Expert, Society for Immunotherapy of Cancer (SITC) |
| 2024 | AACR Scholar-in-Training Award supported by an independent educational grant from AbbVie, American Association for Cancer Research (AACR) Annual Conference |
| 2024 | NCI-Sponsored Travel Award (Mentor; Awardee - Wang Gong), Cancer Moonshot Immuno-Oncology Translational Network Capstone Meeting, Bethesda, MD |
| 2023 - 2024 | Mentor for class 2023-2024, AADOCR MIND the Future Program |
| 2023 | First Place Award among Ph.D. students, postdoctoral trainees, and staff, Basic Science Research and Translational Science Category, University of Michigan School of Dentistry Research Day |
| 2022 | Basic and Translational Research Award, 27th Annual Hinman Student Research Symposium |
| 2022 | Emerging Leaders in Health and Medicine, United States National Academy of Medicine |
| 2021 | Single-Cell Multimodal Data Integration Competition for Modality Prediction, 35th Neural Information Processing Systems Conference |
| 2021 - 2022 | Mentor for class 2021-2022, AADOCR MIND the Future Program |
| 2021 | Balint-Orban Memorial Award Basic Science Winner, American Academy of Periodontology |
| 2021 | First Place Award, Single-Cell Multimodal Data Integration Competition for Modality Prediction, 35th Neural Information Processing Systems Conference |
| 2021 | Virtual IMMUNOLOGY2021™ Presidents' Reception, American Association of Immunologists |
| 2019 | Rising Stars Award, National Institutes of Health |
| 2018 | The Autumn Immunology Conference John Wallace Scholarship, Autumn Immunology Conference |
| 2017 | Oral Health Sciences Block Grant |
| 2017 | Annual Conference Poster Winner, American Association of Oral and Maxillofacial Surgeons |
| 2017 | First Place, Joseph Lister Award for New Investigators, International Association for Dental Research |
| 2017 | Star Peer Reviewer, Springer - Head and Neck Pathology |
| 2015 | Benard Maas Fellowship, The University of Michigan |
| 2015 | Rackham Merit Fellowship, The University of Michigan |
| 2014 - 2019 | Dentist-Scientist Pathway to Independence Award, National Institute of Health/National Institute of Dental and Craniofacial Research (NIH/NIDCR) |
| 2014 | The Ruth L. Kirschstein National Research Service Award (NRSA) (T32), National Institute of Health/National Cancer Institute (NIH/NCI) |
| 2014 | Top Reviewer, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology |
| 2013 | Leon Barnes Award, United States & Canadian Academy of Pathology |
| 2012 | Paul E. Strandjord Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists |
| 2010 | Freedland Advanced Dental Education Fellowships, North Carolina Local Section of the American Association for Dental Research |
| 2010 - Present | Derek T. Turner Award for Excellence in Dental Research, North Carolina Local Section of the American Association for Dental Research |
| 2008 | Derek T. Turner Award for Excellence in Dental Research, North Carolina Local Section of the American Association for Dental Research |
| 2006 | Outstanding Graduate Award, Sichuan University |
| 2004 | Outstanding Student Award of Sichuan University, Sichuan University |
| 2004 | Sichuan University Excellent Academic Performance Fellowship, Sichuan University |
| 2002 | Sichuan University Award for Creativity, Sichuan University |
| 2001 | Federal Award for Medical Education |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2025. Red and White Lesions of the Oral Cavity. Invited. 2025 Oral Oncology Symposium. Houston, TX, US.
- 2025. Gingival Overgrowth Associated with Immunotherapy in a Patient with Renal Cell Carcinoma: A Case Report. Albary Z, Chambers M, Lei YL, Won A. Poster. 2025 Oral Oncology Symposium. Houston, TX, US.
- 2017. Type I Interferon Signatures Promote the Immunogenicity of Head and Neck Cancer. Invited. Donald Kerr Symposium - The Microbiome in Oral Health and Disease. Ann Arbor, MI, US.
Regional Presentations
- 2011. Mammary Analogue Secretory Carcinoma. Conference. University of Minnesota School of Dentistry. Minneapolis, MN, US.
National Presentations
- 2025. Gingival Overgrowth Associated with Immunotherapy in a Patient with Renal Cell Carcinoma: A Case Report. Albasry Z, Chambers M, Lei YL, Won A. Poster. 2025 AAOM/EAOM Joint Meeting. Las Vegas, NV, US.
- 2019. Oncogenic Suppression of Innate Immune Sensing of Cancer. Invited. NCI Rising Scholars: Cancer Research Seminar Series. Bethesda, MD, US.
- 2019. The Co-Evolution of HPV and the Immune Sensors in the Oral Cavity. Invited. Donald Kerr Symposium - The Microbiome in Oral Health and Disease. Ann Arbor, MI, US.
- 2019. Oncogenic Regulation of Pattern Recognition Receptor-Mediated Immune Sensing. Invited. Translational Research Cancer Centers Consortium. Seven Springs, PA, US.
- 2018. Sensitizing Oral Cancer to Immune Checkpoint Blockade. Invited. Seidman Cancer Center, Case Western Reserve University. Cleveland, OH, US.
- 2018. Mitigating Head and Neck Cancer Immune Escape. Invited. American Association for Dental, Oral, and Craniofacial Research (AADR). Fort Lauderdale, FL, US.
- 2009. MAVS-mediated apoptosis and its inhibition by viral proteins. IADR General Session. Miami, FL, US.
International Presentations
- 2019. Develop Strategies to Reverse Oncogenic Suppression of Innate Immune Sensors. Invited. Chulalongkorn University. Bangkok, TH.
- 2019. How Do Oral Cancers Turn Cold?. Invited. IADR/AADR HNSCC Immunotherapy Symposium. Vancouver, CA.
- 2017. Keynote: Clinicopathologic Correlation of Oral Diseases. Invited. The Chinese National Congress of Oral Medicine. Chengdu, CN.
- 2017. Joseph Lister Award Competition. Invited. Kenvue. San Francisco, US.
- 2009. MAVS-mediated apoptosis and its inhibition by viral proteins. Invited. International Association for Dental Research. Miami, US.
Formal Peers
- 2014. Visiting Research Assistant Professor. Visiting. Pittsburgh, PA, US.
Grant & Contract Support
| Date: | 2025 - 2026 |
| Title: | Remodeling opioid-induced metabolic stress to improve anti-tumor immunity |
| Funding Source: | MD Anderson Cancer Center Neuroscience Program |
| Role: | PI |
| Date: | 2025 - 2030 |
| Title: | Ontology-based Applications of Multi-disciplinary Knowledge on Orodental Conditions and Outcomes |
| Funding Source: | NIH |
| Role: | Co-I |
| ID: | DE034406 |
| Date: | 2025 - 2027 |
| Title: | Characterizing a novel and potent immunometabolic tumor suppressor |
| Funding Source: | MD Anderson Cancer Center Institutional Research Grant Program |
| Role: | PI |
| Date: | 2024 - 2028 |
| Title: | Intercepting the Evolution of Pro-tumoral Myeloid Cells During the Initiation of Oral Cancer |
| Funding Source: | NIH/NIDCR |
| Role: | Mentor |
| ID: | DE033922 |
| Date: | 2023 - 2025 |
| Title: | Process Development and Preclinical Advancement of a Novel Nanoparticle Formulation for Immune Activation |
| Funding Source: | Saros Therapeutics, Inc |
| Role: | Co-I |
| ID: | CA281497-01A1 |
| Date: | 2023 - 2028 |
| Title: | Advancing On-Slide and Optical Biopsy Tools to Detect High-Risk Oral Premalignancy |
| Funding Source: | NIH/NIDCR |
| Role: | PI |
| ID: | DE033330-01 |
| Date: | 2023 - 2024 |
| Title: | New Nanoparticle Platform for Metallo-Immunotherapy, Phase II |
| Funding Source: | Frankel Innovation Initiative |
| Role: | Co-I |
| Date: | 2023 - 2028 |
| Title: | Restoring the Immunogenicity of Head and Neck Cancer |
| Funding Source: | NIH |
| Role: | PI |
| ID: | DE026728-06A1 |
| Date: | 2023 - 2028 |
| Title: | Examining the role of the miR-181a:Wnt/B-catenin axis in ovarian cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | CA197780-06A1 |
| Date: | 2022 - 2023 |
| Title: | New Immunotherapy against Triple-Negative Breast Cancer |
| Funding Source: | Rogel Cancer Center |
| Role: | Co-I |
| Date: | 2022 - 2023 |
| Title: | New Nanoparticle Platform for Metallo-Immunotherapy, Phase I |
| Funding Source: | Frankel Innovation Initiative |
| Role: | Co-I |
| Date: | 2022 - 2027 |
| Title: | Preclinical development of first-in-class GSTO1 degraders for colorectal cancer |
| Funding Source: | NIH-DHHS |
| Role: | Co-I |
| ID: | CA266513 |
| Date: | 2022 - 2024 |
| Title: | Identifying non-opioid strategies to manage oral cancer pain |
| Funding Source: | NIH-DHHS |
| Role: | PI |
| ID: | DE026728-S1 |
| Date: | 2022 - 2027 |
| Title: | Engineered Nano-formulations for STING Activation |
| Funding Source: | NIH/NIDCR |
| Role: | Co-I |
| ID: | DE031951 |
| Date: | 2022 - 2023 |
| Title: | Exosomes Mediate Resistance to PD-1/PD-L1 Inhibition in Head and Neck Cancer |
| Funding Source: | American Head and Neck Society |
| Role: | Co-I |
| ID: | 22-PAF03603 |
| Date: | 2022 - 2027 |
| Title: | Salivary gland cancer stem cells |
| Funding Source: | NIH/NIDCR |
| Role: | Co-I |
| ID: | DE021139 |
| Date: | 2022 - 2024 |
| Title: | Midlife obesity and prediabetes trigger later life cognitive decline through central nervous system inflammaging and innate immune dysregulation of cGAS/STING |
| Funding Source: | NIH/NIA |
| Role: | Co-I |
| ID: | 1K99 AG071667 |
| Date: | 2021 - 2024 |
| Title: | Targeting TRIM29 to Reverse Immune Checkpoint Inhibitor Resistance in Bladder Cancer |
| Funding Source: | Damon Runyon Cancer Research |
| Role: | Co-I |
| Date: | 2021 - 2026 |
| Title: | New Engineering Strategy for Harnessing Immune System Against Head and Neck Cancer |
| Funding Source: | NIH/NIDCR |
| Role: | Co-I |
| ID: | DE030691 |
| Date: | 2020 - 2025 |
| Title: | Sensitizing High Grade Serous Cancers to Immunotherapy through the Induction of DNA Damage |
| Funding Source: | NIH-DHHS |
| Role: | Co-I |
| ID: | 5 R01 CA251198-05 |
| Date: | 2020 - 2023 |
| Title: | Analysis of the E7-Mediated Mechanism of MHC Class I Repression in HNSCC |
| Funding Source: | NIH/NRSA |
| Role: | Co-I |
| ID: | DE030000-03 |
| Date: | 2020 - 2021 |
| Title: | Integrated Bioinformatics Analysis of Immune Biomarkers in Oral Cancer |
| Funding Source: | American Head and Neck Society |
| Role: | Co-I |
| ID: | PAF03990 |
| Date: | 2020 - 2022 |
| Title: | Quantitative Estimation of Periodontal Inflammation and Tissue Destruction with High-Resolution Ultrasound-Based Imaging |
| Funding Source: | NIH/DHHS |
| Role: | Co-I |
| ID: | 3R21DE02900502 |
| Date: | 2020 - 2025 |
| Title: | Targeting the DNA damage response in combination with radiation to induce innate immunity and improve immunotherapy efficacy in pancreatic cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R01 CA240515 |
| Date: | 2019 - 2024 |
| Title: | Enhance Immunoprevention by Blocking Early Expansion of Suppressive Myeloid Cells – NIH Competitive Administrative Supplement |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | DE02925501 |
| Date: | 2019 - 2023 |
| Title: | Chimeric Antigen Receptor T Cell Design Through Living Cell Systems Biology |
| Funding Source: | NIH/NIBIB |
| Role: | PI |
| ID: | EB028877 |
| Date: | 2019 - 2024 |
| Title: | Hulya Taner - Immuno-Prevention Strategies for High Risk Oral Epithelial Dysplasia |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | U01 DE02925501 |
| Date: | 2019 - 2024 |
| Title: | Robust Immuno-prevention Strategies for High-Risk Oral Epithelial Dysplasia |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | U01 DE02925501 |
| Date: | 2019 - 2021 |
| Title: | NLR and Oral Cancer Immune Escape |
| Funding Source: | NIH/NRSA |
| Role: | Co-PI |
| ID: | DE028740 |
| Date: | 2018 - 2019 |
| Title: | Drug-like small molecule modulators for interferons |
| Funding Source: | University of Michigan |
| Role: | Co-PI |
| ID: | U063983 |
| Date: | 2018 - 2020 |
| Title: | Development of a Prognostic Compound Immunoscore for Head and Neck Cancer |
| Funding Source: | NIH |
| Role: | PI |
| ID: | DE027399 |
| Date: | 2018 - 2019 |
| Title: | Targeting SOX2-driven metabolic insufficiency of tumor microenvironment to enhance immunotherapy, Research Training in Experimental Immunology |
| Funding Source: | NIH |
| Role: | Mentor |
| ID: | AI007413 |
| Date: | 2018 - 2019 |
| Title: | Cancer Center Research Committee Grant |
| Funding Source: | University of Michigan Rogel Cancer Center |
| Role: | PI |
| Date: | 2018 - 2023 |
| Title: | Develop a Therapeutic Nano-vaccine against Head and Neck Cancer |
| Funding Source: | NIH |
| Role: | PI |
| ID: | DE026728-01A1 |
| Date: | 2018 - 2019 |
| Title: | Periodontal inflammation quantification with point-of-care ultrasonography – American Academy of Periodontology |
| Funding Source: | American Academy of Periodontology |
| Role: | Co-I |
| ID: | PAF03600 |
| Date: | 2017 - 2019 |
| Title: | Rackham Faculty Allies Diversity Grant Program |
| Funding Source: | University of Michigan Rackham Graduate School |
| Role: | Co-I |
| Date: | 2017 - 2019 |
| Title: | Blake R Heath Support - NIH Diversity Supplement |
| Funding Source: | NIH/NIGMS |
| Role: | PI |
| ID: | DE024173S1 |
| Date: | 2017 - 2018 |
| Title: | A prognostic immunoscore for regenerative therapy in patients with peri-implantitis |
| Funding Source: | University of Michigan School of Dentistry |
| Role: | PI |
| Date: | 2017 - 2018 |
| Title: | Fund for Discovery University of Michigan Comprehensive Cancer Center |
| Funding Source: | University of Michigan |
| Role: | PI |
| ID: | 19423 |
| Date: | 2016 - 2017 |
| Title: | Predoctoral T32 Trainee: Blake R. Heath, NLRC3 and Oral Cancer Immune Escape, Research Training in Experimental Immunology |
| Funding Source: | 50000 |
| Role: | Co-I |
| ID: | AI007413-25 |
| Date: | 2016 - 2020 |
| Title: | Autophagy-promoting NLRX1-TUFM complex and cancer cell resistance to cetuximab |
| Funding Source: | NIH |
| Role: | PI |
| ID: | 5R00DE024173 |
| Date: | 2016 - 2020 |
| Title: | Autophagy-Promoting NLRX1-TUFM Complex and Cancer Cell Resistance to Cetuximab |
| Funding Source: | NIH/NIDCR |
| Role: | PI |
| ID: | 5R00 DE024173 |
| Date: | 2016 - 2018 |
| Title: | High throughput genetic screening system |
| Funding Source: | University of Michigan MCube |
| Role: | PI |
| ID: | U049689 |
| Date: | 2014 - 2016 |
| Title: | High through-put genetic screening system |
| Funding Source: | University of Michigan MCube |
| Role: | PI |
| ID: | U049689 |
| Date: | 2014 - 2016 |
| Title: | Autophagy-Promoting NLRX1-TUFM Complex and Cancer Cell Resistance to Cetuximab |
| Funding Source: | NIH |
| Role: | PI |
| ID: | DE024173 |
Selected Publications
Peer-Reviewed Articles
- Zhang J, Ding Q, Wang AX, Lin M, Yu N, Moss K, Williamson MA, Miao D, Marchesan JT, Zeng E, Shi W, Sun H, Lei YL, Zhang S. Type I interferon protects against bone loss in periodontitis by mitigating an interleukin (IL)-17-neutrophil axis. Life Sci 371:123559, 2025. e-Pub 2025. PMID: 40086745.
- Valvo VM, Zhang Q, Jiang L, Holcomb EA, Pearson AN, Edmunds AG, Faulkner HG, James JG, Tate A, Huber AK, Wang Z, Guo Y, Karnak D, Parsels LA, Parsels JD, Lei YL, Rehemtulla A, Lin H, Carpenter ES, Wahl DR, Sahai V, Lawrence TS, Green MD, Morgan MA. Olaparib and Radiotherapy Induce Type I Interferon- and CD8+ T Cell-Dependent Sensitization to Immunotherapy in Pancreatic Cancer. Mol Cancer Ther 24(6):843-858, 2025. e-Pub 2025. PMID: 39688341.
- Juhong, A, Li, B, Liu, Y, Yao, CY, Yang, CW, Ullah, AK, Liu, K, Lewandowski, RP, Harkema, JR, Agnew, DW, Lei, YL, Luker, GD, Huang, X, Piyawattanametha, W, Qiu, Z. Monocular depth estimation based on deep learning for intraoperative guidance using surface-enhanced Raman scattering imaging. Photonics Research 13(2):550-560, 2025. e-Pub 2025.
- Taner HF, Gong W, Fitzsimonds ZR, Li Z, Wu Y, He Y, Okuyama K, Cheng W, Kuczura J, Rajesh S, Manousidaki A, Feng S, Lee M, Nor F, Lanzel E, Demehri S, Polverini PJ, Nor JE, Wang TD, Que J, Wen H, Xie Y, Moon JJ, Lei YL. SOX2-induced IL1alpha-mediated immune suppression drives epithelial dysplasia malignant transformation. bioRxiv, 2024. e-Pub 2024. PMID: 39713429.
- Nakatsuka E, Tan L, Cunneen B, Foster C, Lei YL, McLean K. Characterization of DNA damage repair pathway utilization in high-grade serous ovarian cancers yields rational therapeutic approaches. Transl Oncol 50:102119, 2024. e-Pub 2024. PMID: 39270525.
- Chen J, Zhao B, Dong H, Li T, Cheng X, Gong W, Wang J, Zhang J, Xin G, Yu Y, Lei YL, Black JD, Li Z, Wen H. Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway. Elife 13, 2024. e-Pub 2024. PMID: 39365288.
- Juhong, A, Li, B, Liu, Y, Yang, CW, Yao, CY, Agnew, DW, Lei, YL, Luker, GD, Bumpers, H, Huang, X, Piyawattanametha, W, Qiu, Z. Multihead Attention U-Net for Magnetic Particle Imaging–Computed Tomography Image Segmentation. Advanced Intelligent Systems 6(10), 2024. e-Pub 2024.
- Han K, Xie F, Animasahun O, Nenwani M, Kitamoto S, Kim Y, Phoo MT, Xu J, Wuchu F, Omoloja K, Achreja A, Choppara S, Li Z, Gong W, Cho YS, Dobson H, Ahn J, Zhou X, Huang X, An X, Kim A, Xu Y, Wu Q, Lee SH, O'Konek JJ, Xie Y, Lei YL, Kamada N, Nagrath D, Moon JJ. Inulin-gel-based oral immunotherapy remodels the small intestinal microbiome and suppresses food allergy. Nat Mater 23(10):1444-1455, 2024. e-Pub 2024. PMID: 38977883.
- Ding J, Li L, Lu Q, Venegas J, Wang Y, Wu L, Jin W, Wen H, Liu R, Tang W, Dai X, Li Z, Zuo W, Chang Y, Lei YL, Shang L, Danaher P, Xie Y, Tang J. SpatialCTD: A Large-Scale Tumor Microenvironment Spatial Transcriptomic Dataset to Evaluate Cell Type Deconvolution for Immuno-Oncology. J Comput Biol. e-Pub 2024. PMID: 39117342.
- Chen J, Zhao B, Dong H, Li T, Cheng X, Gong W, Wang J, Zhang J, Xin G, Yu Y, Lei YL, Black JD, Li Z, Wen H. Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway. bioRxiv, 2024. e-Pub 2024. PMID: 38168435.
- Li C, Clauson R, Bugada LF, Ke F, He B, Yu Z, Chen H, Jacobovitz B, Hu H, Chuikov P, Hill BD, Rizvi SM, Song Y, Sun K, Axenov P, Huynh D, Wang X, Garmire L, Lei YL, Grigorova I, Wen F, Cascalho M, Gao W, Sun D. Antigen-Clustered Nanovaccine Achieves Long-Term Tumor Remission by Promoting B/CD 4 T Cell Crosstalk. ACS Nano 18(13):9584-9604, 2024. e-Pub 2024. PMID: 38513119.
- Aikins ME, Sun X, Dobson H, Zhou X, Xu Y, Lei YL, Moon JJ. STING-activating cyclic dinucleotide-manganese nanoparticles evoke robust immunity against acute myeloid leukemia. J Control Release 368:768-779, 2024. e-Pub 2024. PMID: 38492861.
- Sun X, Huang X, Park KS, Zhou X, Kennedy AA, Pretto CD, Wu Q, Wan Z, Xu Y, Gong W, Sexton JZ, Tai AW, Lei YL, Moon JJ. Self-Assembled STING-Activating Coordination Nanoparticles for Cancer Immunotherapy and Vaccine Applications. ACS Nano 18(15):10439-10453, 2024. e-Pub 2024. PMID: 38567994.
- Molho, D, Ding, J, Tang, W, Li, Z, Wen, H, Wang, Y, Venegas, J, Jin, W, Liu, R, Su, R, Danaher, P, Yang, R, Lei, YL, Xie, Y, Tang, J. Deep Learning in Single-cell Analysis. ACM Transactions on Intelligent Systems and Technology 15(3), 2024. e-Pub 2024.
- Deng GL, Lei YL, Tan H, Geng BC, Liu Z. Effects of predictive nursing interventions on pressure ulcer in elderly bedridden patients. Int Wound J 21(3):e14690, 2024. e-Pub 2024. PMID: 38453139.
- Lo BC, Kryczek I, Yu J, Vatan L, Caruso R, Matsumoto M, Sato Y, Shaw MH, Inohara N, Xie Y, Lei YL, Zou W, Núñez G. Microbiota-dependent activation of CD4+ T cells induces CTLA-4 blockade-associated colitis via Fcγ receptors. Science 383(6678):62-70, 2024. e-Pub 2024. PMID: 38175892.
- Juhong A, Li B, Liu Y, Yao CY, Yang CW, Agnew DW, Lei YL, Luker GD, Bumpers H, Huang X, Piyawattanametha W, Qiu Z. Recurrent and convolutional neural networks for sequential multispectral optoacoustic tomography (MSOT) imaging. J Biophotonics 16(11):e202300142, 2023. e-Pub 2023. PMID: 37382181.
- Juhong, A, Li, B, Yao, CY, Yang, CW, Liu, K, Agnew, DW, Lei, YL, Luker, GD, Bumpers, H, Huang, X, Piyawattanametha, W, Qiu, Z. Cost-Effective Near Infrared Fluorescence Wide-Field Camera for Breast Tumor Imaging. IEEE Photonics Technology Letters 35(15):813-816, 2023. e-Pub 2023.
- Sun X, Zhou X, Lei YL, Moon JJ. Unlocking the promise of systemic STING agonist for cancer immunotherapy. J Control Release 357:417-421, 2023. e-Pub 2023. PMID: 37001564.
- Xu C, Dobson HE, Yu M, Gong W, Sun X, Park KS, Kennedy A, Zhou X, Xu J, Xu Y, Tai AW, Lei YL, Moon JJ. STING agonist-loaded mesoporous manganese-silica nanoparticles for vaccine applications. J Control Release 357:84-93, 2023. e-Pub 2023. PMID: 36948420.
- Heath BR, Gong W, Taner HF, Broses L, Okuyama K, Cheng W, Jin M, Fitzsimonds ZR, Manousidaki A, Wu Y, Zhang S, Wen H, Chinn SB, Bartee E, Xie Y, Moon JJ, Lei YL. Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING. Cell Rep 42(4):112303, 2023. e-Pub 2023. PMID: 36952341.
- Barnett KC, Xie Y, Asakura T, Song D, Liang K, Taft-Benz SA, Guo H, Yang S, Okuda K, Gilmore RC, Loome JF, Oguin Iii TH, Sempowski GD, Randell SH, Heise MT, Lei YL, Boucher RC, Ting JP. An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2. Cell Host Microbe 31(2):243-259.e6, 2023. e-Pub 2023. PMID: 36563691.
- Juhong A, Li B, Yao CY, Yang CW, Agnew DW, Lei YL, Huang X, Piyawattanametha W, Qiu Z. Super-resolution and segmentation deep learning for breast cancer histopathology image analysis. Biomed Opt Express 14(1):18-36, 2023. e-Pub 2023. PMID: 36698665.
- Zhang J, Sun L, Withanage MHH, Ganesan SM, Williamson MA, Marchesan JT, Jiao Y, Teles FR, Yu N, Liu Y, Wu D, Moss KL, Mangalam AK, Zeng E, Lei YL, Zhang S. TRAF3IP2-IL-17 Axis Strengthens the Gingival Defense against Pathogens. J Dent Res 102(1):103-115, 2023. e-Pub 2023. PMID: 36281065.
- Zhao B, Gong W, Ma A, Chen J, Velegraki M, Dong H, Liu Z, Wang L, Okimoto T, Jones DM, Lei YL, Long M, Oestreich KJ, Ma Q, Xin G, Carbone DP, He K, Li Z, Wen H. SUSD2 suppresses CD8+ T cell antitumor immunity by targeting IL-2 receptor signaling. Nat Immunol 23(11):1588-1599, 2022. e-Pub 2022. PMID: 36266363.
- Hong HS, Mbah NE, Shan M, Loesel K, Lin L, Sajjakulnukit P, Correa LO, Andren A, Lin J, Hayashi A, Magnuson B, Chen J, Li Z, Xie Y, Zhang L, Goldstein DR, Carty SA, Lei YL, Opipari AW, Argüello RJ, Kryczek I, Kamada N, Zou W, Franchi L, Lyssiotis CA. OXPHOS promotes apoptotic resistance and cellular persistence in TH17 cells in the periphery and tumor microenvironment. Sci Immunol 7(77):eabm8182, 2022. e-Pub 2022. PMID: 36399539.
- Zhai Z, Lei YL, Wang R, Xie Y. Supervised capacity preserving mapping: a clustering guided visualization method for scRNA-seq data. Bioinformatics 38(9):2496-2503, 2022. e-Pub 2022. PMID: 35253834.
- Michmerhuizen NL, Heenan C, Wang J, Leonard E, Bellile E, Loganathan SK, Wong SY, Lei YL, Brenner JC. Combined Pik3ca-H1047R and loss-of-function Notch1 alleles decrease survival time in a 4-nitroquinoline N-oxide-driven head and neck squamous cell carcinoma model. Oral Oncol 126:105770, 2022. e-Pub 2022. PMID: 35172244.
- Sun X, Zhang Y, Li J, Park KS, Han K, Zhou X, Xu Y, Nam J, Xu J, Shi X, Wei L, Lei YL, Moon JJ. Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy. Nat Nanotechnol 16(11):1260-1270, 2021. e-Pub 2021. PMID: 34594005.
- Li T, Kong L, Li X, Wu S, Attri KS, Li Y, Gong W, Zhao B, Li L, Herring LE, Asara JM, Xu L, Luo X, Lei YL, Ma Q, Seveau S, Gunn JS, Cheng X, Singh PK, Green DR, Wang H, Wen H. Listeria monocytogenes upregulates mitochondrial calcium signalling to inhibit LC3-associated phagocytosis as a survival strategy. Nat Microbiol 6(3):366-379, 2021. e-Pub 2021. PMID: 33462436.
- Donnelly CR, Jiang C, Andriessen AS, Wang K, Wang Z, Ding H, Zhao J, Luo X, Lee MS, Lei YL, Maixner W, Ko MC, Ji RR. STING controls nociception via type I interferon signalling in sensory neurons. Nature 591(7849):275-280, 2021. e-Pub 2021. PMID: 33442058.
- Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, ÉMC Á, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Á B, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, B. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1. Autophagy 17(1):1-382, 2021. e-Pub 2021. PMID: 33634751.
- Gong W, Donnelly CR, Heath BR, Bellile E, Donnelly LA, Taner HF, Broses L, Brenner JC, Chinn SB, Ji RR, Wen H, Nör JE, Wang J, Wolf GT, Xie Y, Lei YL. Cancer-specific type-I interferon receptor signaling promotes cancer stemness and effector CD8+ T-cell exhaustion. Oncoimmunology 10(1):1997385, 2021. e-Pub 2021. PMID: 34858725.
- Wang CW, Hao Y, Di Gianfilippo R, Sugai J, Li J, Gong W, Kornman KS, Wang HL, Kamada N, Xie Y, Giannobile WV, Lei YL. Machine learning-assisted immune profiling stratifies peri-implantitis patients with unique microbial colonization and clinical outcomes. Theranostics 11(14):6703-6716, 2021. e-Pub 2021. PMID: 34093848.
- Kürten CHL, Deuß E, Lei YL, Höing B, Kramer B, Lang S, Ferris RL, Kansy BA. [Stimulatory and inhibitory signaling pathways of the T cell-APC interaction and the effect of TLR agonists on APCs]. HNO 68(12):916-921, 2020. e-Pub 2020. PMID: 33128107.
- Kitamoto S, Nagao-Kitamoto H, Jiao Y, Gillilland MG, Hayashi A, Imai J, Sugihara K, Miyoshi M, Brazil JC, Kuffa P, Hill BD, Rizvi SM, Wen F, Bishu S, Inohara N, Eaton KA, Nusrat A, Lei YL, Giannobile WV, Kamada N. The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis. Cell 182(2):447-462.e14, 2020. e-Pub 2020. PMID: 32758418.
- Deng M, Tam JW, Wang L, Liang K, Li S, Zhang L, Guo H, Luo X, Zhang Y, Petrucelli A, Davis BK, Conti BJ, June Brickey W, Ko CC, Lei YL, Sun S, Ting JP. TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. Nat Commun 11(1):2193, 2020. e-Pub 2020. PMID: 32366851.
- Luo X, Donnelly CR, Gong W, Heath BR, Hao Y, Donnelly LA, Moghbeli T, Tan YS, Lin X, Bellile E, Kansy BA, Carey TE, Brenner JC, Cheng L, Polverini PJ, Morgan MA, Wen H, Prince ME, Ferris RL, Xie Y, Young S, Wolf GT, Chen Q, Lei YL. HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING. J Clin Invest 130(4):1635-1652, 2020. e-Pub 2020. PMID: 31874109.
- Sun L, Girnary M, Wang L, Jiao Y, Zeng E, Mercer K, Zhang J, Marchesan JT, Yu N, Moss K, Lei YL, Offenbacher S, Zhang S. IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network. J Immunol 204(8):2177-2191, 2020. e-Pub 2020. PMID: 32169848.
- Sandulache VC, Lei YL, Heasley LE, Chang M, Amos CI, Sturgis EM, Graboyes E, Chiao EY, Rogus-Pulia N, Lewis J, Madabhushi A, Frederick MJ, Sabichi A, Ittmann M, Yarbrough WG, Chung CH, Ferrarotto R, Mai W, Skinner HD, Duvvuri U, Gerngross P, Sikora AG. Innovations in risk-stratification and treatment of Veterans with oropharynx cancer; roadmap of the 2019 Field Based Meeting. Oral Oncol 102:104440, 2020. e-Pub 2020. PMID: 31648864.
- Lu T, Tang J, Shrestha B, Heath BR, Hong L, Lei YL, Ljungman M, Neamati N. Up-regulation of hypoxia-inducible factor antisense as a novel approach to treat ovarian cancer. Theranostics 10(15):6959-6976, 2020. e-Pub 2020. PMID: 32550915.
- Zhang Q, Green MD, Lang X, Lazarus J, Parsels JD, Wei S, Parsels LA, Shi J, Ramnath N, Wahl DR, Pasca di Magliano M, Frankel TL, Kryczek I, Lei YL, Lawrence TS, Zou W, Morgan MA. Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy. Cancer Res 79(15):3940-3951, 2019. e-Pub 2019. PMID: 31101760.
- Raghavan S, Mehta P, Xie Y, Lei YL, Mehta G. Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments. J Immunother Cancer 7(1):190, 2019. e-Pub 2019. PMID: 31324218.
- Lei YL, Veliceasa D, Lamano JB, Lamano JB, Kaur G, Biyashev D, Horbinski CM, Kruser TJ, Bloch O. Systemic and local immunosuppression in patients with high-grade meningiomas. Cancer Immunol Immunother 68(6):999-1009, 2019. e-Pub 2019. PMID: 31030234.
- Hao Y, Yan M, Heath BR, Lei YL, Xie Y. Fast and robust deconvolution of tumor infiltrating lymphocyte from expression profiles using least trimmed squares. PLoS Comput Biol 15(5):e1006976, 2019. e-Pub 2019. PMID: 31059559.
- Li X, Gong W, Wang H, Li T, Attri KS, Lewis RE, Kalil AC, Bhinderwala F, Powers R, Yin G, Herring LE, Asara JM, Lei YL, Yang X, Rodriguez DA, Yang M, Green DR, Singh PK, Wen H. O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. Immunity 50(4):1115, 2019. e-Pub 2019. PMID: 30995496.
- Li X, Gong W, Wang H, Li T, Attri KS, Lewis RE, Kalil AC, Bhinderwala F, Powers R, Yin G, Herring LE, Asara JM, Lei YL, Yang X, Rodriguez DA, Yang M, Green DR, Singh PK, Wen H. O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. Immunity 50(3):576-590.e6, 2019. e-Pub 2019. PMID: 30770249.
- Dharmaraj N, Piotrowski SL, Huang C, Newton JM, Golfman LS, Hanoteau A, Koshy ST, Li AW, Pulikkathara MX, Zhang B, Burks JK, Mooney DJ, Lei YL, Sikora AG, Young S. Anti-tumor immunity induced by ectopic expression of viral antigens is transient and limited by immune escape. Oncoimmunology 8(4):e1568809, 2019. e-Pub 2019. PMID: 30906661.
- Wolf GT, Winter W, Bellile E, Nguyen A, Donnelly CR, McHugh JB, Thomas D, Amlani L, Rozek L, Lei YL, Head, Program NS. Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck. Oral Oncol 87:29-35, 2018. e-Pub 2018. PMID: 30527240.
- Li T, Li X, Attri KS, Liu C, Li L, Herring LE, Asara JM, Lei YL, Singh PK, Gao C, Wen H. O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity. Cell Host Microbe 24(6):791-803.e6, 2018. e-Pub 2018. PMID: 30543776.
- Tan YS, Sansanaphongpricha K, Xie Y, Donnelly CR, Luo X, Heath BR, Zhao X, Bellile E, Hu H, Chen H, Polverini PJ, Chen Q, Young S, Carey TE, Nör JE, Ferris RL, Wolf GT, Sun D, Lei YL. Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine. Clin Cancer Res 24(17):4242-4255, 2018. e-Pub 2018. PMID: 29769207.
- Leach DG, Dharmaraj N, Piotrowski SL, Lopez-Silva TL, Lei YL, Sikora AG, Young S, Hartgerink JD. STINGel: Controlled release of a cyclic dinucleotide for enhanced cancer immunotherapy. Biomaterials 163:67-75, 2018. e-Pub 2018. PMID: 29454236.
- Kansy BA, Shayan G, Jie HB, Gibson SP, Lei YL, Brandau S, Lang S, Schmitt NC, Ding F, Lin Y, Ferris RL. T cell receptor richness in peripheral blood increases after cetuximab therapy and correlates with therapeutic response. Oncoimmunology 7(11):e1494112, 2018. e-Pub 2018. PMID: 30377562.
- Lei Y, Kansy BA, Li J, Cong L, Liu Y, Trivedi S, Wen H, Ting JP, Ouyang H, Ferris RL. EGFR-targeted mAb therapy modulates autophagy in head and neck squamous cell carcinoma through NLRX1-TUFM protein complex. Oncogene 35(36):4698-707, 2016. e-Pub 2016. PMID: 26876213.
- Concha-Benavente F, Srivastava RM, Trivedi S, Lei Y, Chandran U, Seethala RR, Freeman GJ, Ferris RL. Identification of the Cell-Intrinsic and -Extrinsic Pathways Downstream of EGFR and IFNγ That Induce PD-L1 Expression in Head and Neck Cancer. Cancer Res 76(5):1031-43, 2016. e-Pub 2016. PMID: 26676749.
- Li J, Jie HB, Lei Y, Gildener-Leapman N, Trivedi S, Green T, Kane LP, Ferris RL. PD-1/SHP-2 inhibits Tc1/Th1 phenotypic responses and the activation of T cells in the tumor microenvironment. Cancer Res 75(3):508-518, 2015. e-Pub 2015. PMID: 25480946.
- Schuler PJ, Harasymczuk M, Visus C, Deleo A, Trivedi S, Lei Y, Argiris A, Gooding W, Butterfield LH, Whiteside TL, Ferris RL. Phase I dendritic cell p53 peptide vaccine for head and neck cancer. Clin Cancer Res 20(9):2433-44, 2014. e-Pub 2014. PMID: 24583792.
- Lei Y, Jaradat JM, Owosho A, Adebiyi KE, Lybrand KS, Neville BW, Müller S, Bilodeau EA. Evaluation of SOX2 as a potential marker for ameloblastic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol 117(5):608-616.e1, 2014. e-Pub 2014. PMID: 24603057.
- Lei Y, Lui VW, Grandis JR, Egloff AM. Identification of mutations in the PYRIN-containing NLR genes (NLRP) in Head and Neck Squamous Cell Carcinoma. PLoS One 9(1):e85619, 2014. e-Pub 2014. PMID: 24465623.
- Lei Y, Wen H, Ting JP. The NLR protein, NLRX1, and its partner, TUFM, reduce type I interferon, and enhance autophagy. Autophagy 9(3):432-3, 2013. e-Pub 2013. PMID: 23321557.
- Taxman DJ, Lei Y, Zhang S, Holley-Guthrie E, Offenbacher S, Ting JP. ASC-dependent RIP2 kinase regulates reduced PGE2 production in chronic periodontitis. J Dent Res 91(9):877-82, 2012. e-Pub 2012. PMID: 22828789.
- Lei Y, Wen H, Yu Y, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania B, Moore CB, Giguère PM, Siderovski DP, Hiscott J, Razani B, Semenkovich CF, Chen X, Ting JP. The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity 36(6):933-46, 2012. e-Pub 2012. PMID: 22749352.
- Lei Y, Chiosea SI. Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools. Head Neck Pathol 6(2):166-70, 2012. e-Pub 2012. PMID: 22127547.
- Allen IC, Moore CB, Schneider M, Lei Y, Davis BK, Scull MA, Gris D, Roney KE, Zimmermann AG, Bowzard JB, Ranjan P, Monroe KM, Pickles RJ, Sambhara S, Ting JP. NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways. Immunity 34(6):854-65, 2011. e-Pub 2011. PMID: 21703540.
- Taxman DJ, Holley-Guthrie EA, Huang MT, Moore CB, Bergstralh DT, Allen IC, Lei Y, Gris D, Ting JP. The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. J Biol Chem 286(22):19605-16, 2011. e-Pub 2011. PMID: 21487011.
- Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, Brickey WJ, Ting JP. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 12(5):408-15, 2011. e-Pub 2011. PMID: 21478880.
- Wen H, Lei Y, Eun SY, Ting JP. Plexin-A4-semaphorin 3A signaling is required for Toll-like receptor- and sepsis-induced cytokine storm. J Exp Med 207(13):2943-57, 2010. e-Pub 2010. PMID: 21098092.
- Lei Y, Moore CB, Liesman RM, O'Connor BP, Bergstralh DT, Chen ZJ, Pickles RJ, Ting JP. MAVS-mediated apoptosis and its inhibition by viral proteins. PLoS One 4(5):e5466, 2009. e-Pub 2009. PMID: 19404494.
- Moore CB, Bergstralh DT, Duncan JA, Yb L, Morrison TE, Zimmermann AG, Accavitti-Loper MA, Madden VJ, Sun L, Ye Z, Lich JD, Heise MT, Chen Z, Ting JP. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature 451(7178):573-7, 2008. e-Pub 2008. PMID: 18200010.
- Zhang WQ, Zhu ZM, Chao YL, Lei Y, Cui J. [Effects of hypotonic solution on the proliferation, alkaline phosphatase activity and [Ca2+]i concentration of osteoblast-like cells]. Sichuan Da Xue Xue Bao Yi Xue Ban 38(4):649-52, 2007. e-Pub 2007. PMID: 17718432.
Review Articles
- Hussein NI, Molina AH, Sunga GM, Amit M, Lei YL, Zhao X, Hartgerink JD, Sikora AG, Young S. Localized intratumoral delivery of immunomodulators for oral cancer and oral potentially malignant disorders. Oral Oncol 158:106986, 2024. e-Pub 2024. PMID: 39137489.
- Sun X, Zhou X, Shi X, Abed OA, An X, Lei YL, Moon JJ. Strategies for the development of metalloimmunotherapies. Nat Biomed Eng 8(9):1073-1091, 2024. e-Pub 2024. PMID: 38914800.
- Luo X, Qiu Y, Fitzsimonds ZR, Wang Q, Chen Q, Lei YL. Immune escape of head and neck cancer mediated by the impaired MHC-I antigen presentation pathway. Oncogene 43(6):388-394, 2024. e-Pub 2024. PMID: 38177410.
- Pearson AN, Carmicheal J, Jiang L, Lei YL, Green MD. Contribution of Lipid Oxidation and Ferroptosis to Radiotherapy Efficacy. Int J Mol Sci 22(22), 2021. e-Pub 2021. PMID: 34830482.
- Farlow JL, Brenner JC, Lei YL, Chinn SB. Immune deserts in head and neck squamous cell carcinoma: A review of challenges and opportunities for modulating the tumor immune microenvironment. Oral Oncol 120:105420, 2021. e-Pub 2021. PMID: 34218062.
- Luo X, Qiu Y, Dinesh P, Gong W, Jiang L, Feng X, Li J, Jiang Y, Lei YL, Chen Q. The functions of autophagy at the tumour-immune interface. J Cell Mol Med 25(5):2333-2341, 2021. e-Pub 2021. PMID: 33605033.
- Zhou Y, Cheng L, Lei YL, Ren B, Zhou X. The Interactions Between Candida albicans and Mucosal Immunity. Front Microbiol 12:652725, 2021. e-Pub 2021. PMID: 34234752.
- Heath BR, Michmerhuizen NL, Donnelly CR, Sansanaphongpricha K, Sun D, Brenner JC, Lei YL. Head and Neck Cancer Immunotherapy beyond the Checkpoint Blockade. J Dent Res 98(10):1073-1080, 2019. e-Pub 2019. PMID: 31340724.
- Tan YS, Sansanaphongpricha K, Prince MEP, Sun D, Wolf GT, Lei YL. Engineering Vaccines to Reprogram Immunity against Head and Neck Cancer. J Dent Res 97(6):627-634, 2018. e-Pub 2018. PMID: 29533731.
- Polverini PJ, D'Silva NJ, Lei YL. Precision Therapy of Head and Neck Squamous Cell Carcinoma. J Dent Res 97(6):614-621, 2018. e-Pub 2018. PMID: 29649374.
- Lei Y, Xie Y, Tan YS, Prince ME, Moyer JS, Nör J, Wolf GT. Telltale tumor infiltrating lymphocytes (TIL) in oral, head & neck cancer. Oral Oncol 61:159-65, 2016. e-Pub 2016. PMID: 27553942.
- Ting JP, Duncan JA, Lei Y. How the noninflammasome NLRs function in the innate immune system. Science 327(5963):286-90, 2010. e-Pub 2010. PMID: 20075243.
Abstracts
- Gong W, Taner HF, Wu Y, Li Z, Cheng W, Donnelly CR, Nör F, He Y, Fitzsimonds Z, Li J, Chinn SB, Xie Y, Moon JJ, Lei YL. Metabolic inhibition of BATF2 dampens type-I interferon-mediated immune sensing of cancer. Cancer Moonshot Immuno-Oncology Translational Network Capstone Meeting. Building 10, NIH. Bethesda, MD, 2024, 2024. e-Pub 2024.
- Ding J, Li L, Lu Q, Venegas J, Wang Y, Wu L, Jin W, Wen H, Liu R, Tang W, Li Z, Zuo W, Chang Y, Lei YL, Shang L, Danaher P, Xie Y, Tang J. SPATIALCTD: a large-scale TME spatial transcriptomic dataset to evaluate cell type deconvolution for immuno-oncology. 28th Annual International Conference on Research in Computational Molecular Biology (RECOMB), Boston, MA, 2024, 2024. e-Pub 2024.
- Zhou X, Sun X, Gong W, Wan Z, Krieger-Burke T, Yuzbasiyan-Gurkan V, Lei YL, Moon J. Enhancing STING activation by cyclic dinucleotide-manganese particles for systemic cancer immunotherapy. Cancer Res 84 (6_Supplement): 3187, 2024. AACR Annual Conference. San Diego, CA, 2024, 2024. e-Pub 2024.
- Gong W, Taner HF, Wu Y, Li Z, Cheng W, Donnelly CR, Nör F, He Y, Fitzsimonds Z, Li J, Chinn SB, Xie Y, Moon JJ, Lei YL. Metabolic inhibition of BATF2 dampens type-I interferon-mediated immune sensing of cancer. Cancer Research 84 (6_Supplement), 3927-3927, 2024, AACR Annual Conference, San Diego, CA, 2024, 2024. e-Pub 2024.
- Taner HF, Gong W, Li Z, Wu Y, He Y, Fitzsimonds Z, Cheng W, Nor F, Lanzel E, Tan YS, Demehri S, Wolf GT, Polverini PJ, Donnelly CR, Wen H, Que J, Chinn SB, Nör J, Wang T, Moon JJ, Xie Y, Lei YL. Intercepting the evolution of pro-tumoral myeloid cells during the initiation of oral cancer. Cancer Moonshot Immuno-Oncology Translational Network Capstone Meeting. Building 10, NIH. Bethesda, MD, 2024, 2024. e-Pub 2024.
- DiFeo A, Colina J, Cho K, Orsulic S, Skala S, Burdette JE, Leo Lei YL, Drapkin R, Shen H, Puleo N, Ram H, Cusato M, Sobeck A, Sol Recouvreux M, Johnson B, Rivera G, Avelar R, Zhai Y, McAnulty J. Ciliated cells prevent high grade serous cancer by regulating STING-p53 DNA damage response. 15th Biennial Ovarian Cancer Research Symposium. 2024. 15th Biennial Ovarian Cancer Research Symposium, Seattle, WA, 2024. e-Pub 2024.
- Wang Y, Ding J, Wu L, Wardhani A, Danaher P, Lu Q, Wen H, Tang W, Chang Y, Lei YL, Tang J, Xie Y. MEM-GAN: a pseudo membrane generator for single-cell imaging in fluorescent microscopy. 28th Annual International Conference on Research in Computational Molecular Biology (RECOMB), Boston, MA, 2024. e-Pub 2024.
- Zhou X, Sun X, Gong W, Wan Z, Lei YL, Moon JJ. Enhancing STING activation by cyclic dinucleotide-manganese particles for systemic cancer immunotherapy. Society of Immunotherapy of Cancer Annual Conference. San Diego, CA, 2023, 2023. e-Pub 2023.
- Gong W, Taner H, Wu Y, Cheng W, Okuyama K, Li Z, Demehri S, Nagrath D, Chinn SB, Moon JJ, Xie Y, Lei YL. BATF2 suppresses cancer initiation by promoting γδ T-cell-mediated Immunity. Cancer Moonshot Immuno-Oncology Translational Network Conference. Bethesda, MD, 2023, 2023. e-Pub 2023.
- Barnett KC, Xie Y, Asakura T, Song D, Liang K, Taft-Benz SA, Guo H, Yang S, Okuda K, Gilmore RC, Loome JF, Oguin T, Sempowski GD, Randell SH, Heise MT, Lei YL, Boucher RC, JP-Y T. Bi-directional epithelial-immune communication amplifies inflammasome activation and IL-6 release during SARS-CoV-2 infection. J Immunol. 2023; 210 (1_Supplement): 167.10. Presented at the AAI Annual Conference, Washington DC. 2023, 2023. e-Pub 2023.
- Liang K, Barnett KC, Xie Y, Oguin T, Sempowski GD, Lei YL, JP-Y T. Unraveling the cell death induced by SARS-CoV-2 in lung epithelial cells. J Immunol. 2023; 210 (1_Supplement): 162.10. Presented at the AAI Annual Conference, Washington DC. 2023, 2023. e-Pub 2023.
- Gong W, Taner H, Cheng W, Wu Y, Donnelly CR, Nor F, Li Z, Zhai Z, Fitzsimonds Z, He Y, Broses L, Li J, Bellile E, Wolf GT, Wen H, Xie Y, Akira S, Moon JJ, Lei YL. BATF2 suppresses cancer initiation by promoting γδ T-cell-mediated Immunity. James P. Allison Institute Symposium: "Immunotherapy in Space and Time: The Tumor Microenvironment, 2024.
Book Chapters
- Tan YS, Lei YL. Generation and Culture of Mouse Embryonic Fibroblasts. In: Methods Mol Biol, 85-91, 2019.
- Tan YS, Lei YL. Isolation of Tumor-Infiltrating Lymphocytes by Ficoll-Paque Density Gradient Centrifugation. In: Methods Mol Biol. Irving C Allen Human Press, 93-99, 2019.
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CV information above last modified October 17, 2025