Yun Shin Chun, MD, FACS
Department of Surgical Oncology, Division of Surgery
About Dr. Segraves (Chun)
I am a surgical oncologist dedicated to the care of patients with malignancies of the liver and biliary tract. My research focus is optimizing patient selection for hepatic resection using molecular markers, mutational profiles, and response to systemic therapy. I am co-principal investigator on an R01 grant awarded to MD Anderson and Memorial Sloan-Kettering Cancer Center, entitled Development and Validation of Prognostic Radiomic Markers of Response and Recurrence for Patients with Colorectal Liver Metastases. I am Core Leader on a Specialized Programs of Research Excellence (SPORE) grant on hepatocellular carcinoma awarded to MD Anderson. As a member of The Pathology and Biobanking Core, I direct the primary liver cancer tissue bank. I am senior author on the first study in the literature on genetic alterations in resected multifocal intrahepatic cholangiocarcinoma. The results demonstrated that genomic profiles are concordant across all tumors in an individual patient, suggesting that multifocal tumors in intrahepatic cholangiocarcinoma represent monoclonal metastatic seeding.
Present Title & Affiliation
Primary Appointment
Professor, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1999 | New York Medical College, Valhalla, NY, USA, MD, Medicine |
| 1994 | Harvard University, Cambridge, MA, USA, BA, French Studies |
Postgraduate Training
| 2006-2009 | Clinical Fellowship, Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2004-2006 | Research Fellowship, Surgical Oncology Research, Memorial Sloan-Kettering Cancer Center, New York, NY |
| 2000-2004 | Clinical Residency, General Surgery, Mayo Clinic, Rochester, MN |
| 1999-2000 | Clinical Internship, General Surgery, Mayo Clinic, Rochester, MN |
Board Certifications
| 2005 | American Board of Surgery |
Experience & Service
Academic Appointments
Associate Professor, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - 2023
Assistant Professor, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - 2017
Assistant Professor, Department of Surgical Oncology, Division of Surgery, Fox Chase Cancer Center, Philadelphia, PA, 2009 - 2013
Administrative Appointments/Responsibilities
Specialized Program of Research Excellence (SPORE) representative on the National Cancer Institute Gastrointestinal Steering Committee, National Cancer Institute, Rockville, MD, 2021 - Present
Site Director, Department of Hepatobiliary Surgery Rotation, Hennepin County Medical Center, Minneapolis, MN, 2014 - 2015
Member, Institutional Review Board, Fox Chase Cancer Center, Philadelphia, PA, 2010 - 2013
Other Appointments/Responsibilities
Expert representative on liver transplant, American College of Radiology Committee on Appropriateness Criteria, Reston, VA, 2022 - Present
Member, Society of Surgical Oncology Hepato-Pancreato-Biliary Disease Work Group, Rosemont, IL, 2022 - 2024
Member, Society for Surgery of the Alimentary Tract International Relations Committee, Beverly, MA, 2021 - Present
Co-Chair, Western Surgical Association Diversity, Equity, and Inclusion Taskforce, Kansas City, MO, 2021 - Present
Member, Americas Hepato-Pancreato-Biliary Association Clinical Trials Committee, Kansas City, MO, 2020 - 2024
Member, International Cholangiocarcinoma Research Network (ICRN) Executive Committee, Salt Lake City, UT, 2017 - Present
Member, Pancreatic Cancer Research Team, Seattle, WA, 2013 - 2015
Director, Hepato-Pancreato-Biliary Programs, Virginia Piper Cancer Institute, Minneapolis, MN, 2013 - 2015
Member, Metro-Minnesota Community Clinical Oncology Program, Minneapolis, MN, 2013 - 2015
Member, American College of Surgeons Oncology Group (ACOSOG) Community Clinical Oncology Program (CCOP) Pancreas Prevention Team, Chicago, IL, 2012 - 2015
Member, Society for Surgery of The Alimentary Tract Program Committee, Beverly, MA, 2012 - Present
Member, National Cancer Institute Pancreas Cancer Task Force, Madison, WI, 2010 - 2011
Member, Americas Hepato-Pancreato-Biliary Association Research Committee, Overland Park, KS, 2010 - 2012
Member, American Joint Committee on Cancer Hepatobiliary Task Force, Chicago, IL, 2007 - 2023
Institutional Committee Activities
Member, Department of Surgical Oncology Fellowship Applicant Review Committee, 2017 - Present
REDCap Expert, Department of Surgical Oncology, 2017 - Present
Member, Transfusion & Patient Blood Management Committee, 2017 - 2019
Member, Department of Surgical Oncology Liver Tumor Study Group Planning Committee, 2017 - Present
Member, Department of Surgical Oncology Research Oversight Committee, 2016 - 2019
Member, Department of Surgery Gender Inclusiveness Committee, 2015 - 2023
Member, Gastrointestinal Cancer Center Support Grant, 2015 - Present
Member, Department of Surgical Oncology Education Committee, 2015 - 2020
Member, Abbott Northwestern Hospital Operating Room Utilization Committee, 2014 - 2015
Member, Allina Health, Cancer Committee, 2013 - 2015
Honors & Awards
| 2011 | Karen and Josef E. Fischer International Traveling Fellowship Award for Surgeons in Academic Practice, Society for Surgery of the Alimentary Tract |
| 2009 | RSNA Certificate of Merit, 95th Scientific Assembly and Annual Meeting of the Radiological Society of North America |
| 2008 | Best Poster Award, 6th International Meeting Hepatocellular Carcinoma: Eastern and Western Experiences, Seoul, South Korea |
| 2007 | The University of Texas MD Anderson Cancer Center Alumni and Faculty Association Trainee Excellence Award |
| 1999 | Janet M. Glasgow Memorial Achievement Citation, New York Medical College |
| 1998 | Alpha Omega Alpha, New York Medical College |
| 1994 | Cum Laude, Harvard University |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Yamashita S, Chun YS, Kopetz SE, Maru D, Conrad C, Aloia TA, Vauthey JN. APC and PIK3CA mutational cooperativity predicts pathologic response and survival in patients undergoing resection for colorectal liver metastases. Ann Surg 272(6):1080-1085, 2020. PMID: 28379870.
- Goffredo P, Utria AF, Beck AC, Chun YS, Howe JR, Weigel RJ, Vauthey JN, Hassan I. The prognostic impact of KRAS mutation in patients having curative resection of synchronous colorectal liver metastases. J Gastrointest Surg 23(10):1957-1963, 2019. e-Pub 2018. PMID: 30276588.
- Cloyd JM, Prakash L, Vauthey JN, Aloia TA, Chun YS, Tzeng CW, Kim MP, Lee JE, Katz MHG. The role of preoperative therapy prior to pancreatoduodenectomy for distal cholangiocarcinoma. Am J Surg 218(1):145-150, 2019. PMID: 30224070.
- Chun YS, Passot G, Yamashita S, Nusrat M, Katsonis P, Loree JM, Conrad C, Tzeng CD, Xiao L, Aloia TA, Eng C, Kopetz SE, Lichtarge O, Vauthey JN. Deleterious effect of RAS and evolutionary high-risk TP53 double mutation in colorectal liver metastases. Ann Surg 269(5):917-23, 2019. e-Pub 2017. PMID: 28767562.
- Ogiso S, Okuno M, Shindoh J, Sakamoto Y, Mizuno T, Araki K, Goumard C, Nomi T, Ishii T, Uemoto S, Chun YS, Tzeng CWD, Lee JE, Vauthey JN, Conrad C. Conceptual framework of middle hepatic vein anatomy as a roadmap for safe right hepatectomy. HPB (Oxford) 21(1):43-50, 2019. PMID: 30266496.
- Okuno M, Goumard C, Mizuno T, Kopetz S, Omichi K, Tzeng CD, Chun YS, Lee JE, Vauthey JN, Conrad C. Prognostic impact of perihepatic lymph node metastases in patients with resectable colorectal liver metastases. Br J Surg 105(9):1200-1209, 2018. PMID: 29664996.
- Cloyd JM, Omichi K, Mizuno T, Kawaguchi Y, Tzeng CD, Conrad C, Chun YS, Aloia TA, Katz MHG, Lee JE, Halperin D, Yao J, Vauthey JN, Dasari A. Preoperative fluorouracil, doxorubicin, and streptozocin for the treatment of pancreatic neuroendocrine liver metastases. Ann Surg Oncol 25(6):1709-1715, 2018. e-Pub 2018.
- Okuno M, Goumard C, Kopetz S, Vega EA, Joechle K, Mizuno T, Omichi K, Tzeng CD, Chun YS, Vauthey JN, Conrad C. RAS mutation is associated with unsalvageable recurrence following hepatectomy for colorectal cancer liver metastases. Ann Surg Oncol 25(8):2457-2466. e-Pub 2018. PMID: 29786130.
- Okuno M, Goumard C, Mizuno T, Omichi K, Tzeng CD, Chun YS, Aloia TA, Fleming JB, Lee JE, Vauthey JN, Conrad C. Operative and short-term oncologic outcomes of laparoscopic versus open liver resection for colorectal liver metastases located in the posterosuperior liver: a propensity score matching analysis. Surg Endosc 32(4):1776-1786, 2018. PMID: 28917012.
- Yamashita S, Brudvik KW, Kopetz SE, Maru D, Clarke CN, Passot G, Conrad C, Chun YS, Aloia TA, Vauthey JN. Embryonic origin of primary colon cancer predicts pathologic response and survival in patients undergoing resection for colon cancer liver metastases. Ann Surg 267(3):514-520, 2018. PMID: 28002060.
- Cloyd JM, Chun YS, Ikoma N, Vauthey JN, Aloia TA, Cuddy A, Rodriguez-Bigas MA, Nancy You Y. Clinical and genetic implications of DNA mismatch repair deficiency in biliary tract cancers associated with lynch syndrome. J Gastrointest Cancer 49(1):93-96, 2018. PMID: 29238914.
- Odisio BC, Yamashita S, Huang SY, Kopetz SE, Ahrar K, Mizuno T, Conrad C, Aloia TA, Chun YS, Gupta S, Vauthey JN. Impact of prior hepatectomy history on local tumor progression after percutaneous ablation of colorectal liver metastases. J Vasc Interv Radiol 29(3):395-403, 2018. e-Pub 2018.
- Mizuno T, Cloyd JM, Vicente D, Omichi K, Chun YS, Kopetz SE, Maru D, Conrad C, Tzeng CD, Wei SH, Aloia TA, Vauthey JN. SMAD4 gene mutation predicts poor prognosis in patients undergoing resection for colorectal liver metastases. Eur J Surg Oncol 44(5):684-692. e-Pub 2018. PMID: 29551247.
- Yamashita S, Chun YS, Kopetz SE, Vauthey JN. Biomarkers in colorectal liver metastases. Br J Surg 105(6):618-627. e-Pub 2018. PMID: 29579319.
- Mizuno T, Cloyd JM, Omichi K, Chun YS, Conrad C, Tzeng CD, Wei SH, Aloia TA, Vauthey JN. Two-Stage hepatectomy vs one-stage major hepatectomy with contralateral resection or ablation for advanced bilobar colorectal liver metastases. J Am Coll Surg 226(5):825-834. e-Pub 2018. PMID: 29454099.
- Omichi K, Yamashita S, Cloyd JM, Shindoh J; Mizuno T, Chun YS, Conrad C, Aloia TA, Vauthey JN, Tzeng CWD. Portal vein embolization reduces postoperative hepatic insufficiency associated with post-chemotherapy hepatic atrophy. J Gastrointest Surg 22(1):60-67, 2018. e-Pub 2017. PMID: 28585106.
- Vega EA, Vinuela E, Yamashita S, Sanhueza M, Cavada G, Diaz C, Aloia TA, Chun YS Tzeng CD, Okuno M, Goumard C, Vauthey JN, Lee JE, Conrad C. Extended lymphadenectomy is required for incidental gallbladder cancer independent of cystic duct lymph node status. J Gastrointest Surg 22(1):43-51, 2018. e-Pub 2017. PMID: 28752405.
- Okuno M, Gourmard C, Mizuno T, Omichi K, Tzeng CD, Chun YS, Lee JE, Vauthey JN, Conrad C. Pathological diaphragmatic invasion by colorectal liver metastases is associated with RAS mutation, peritoneal recurrence and worse survival. HPB (Oxford) 20(1):57-63, 2018. e-Pub 2017.
- Passot G, Kim BJ, Glehen O, Mehran RJ, Kopetz SE, Goere D, Overman MJ, Pocard M, Marchal F, Conrad C, Aloia TA, Vauthey JN, Chun YS, BIG-RENAPE Working Group. Impact of RAS mutations in metastatic colorectal cancer after potentially curative resection: Does site of metastases matter?. Ann Surg Oncol 25(1):179-187, 2018. e-Pub 2017. PMID: 29071660.
- Goumard C, Marcal LP, Wang WL, Somaiah N, Okuno M, Roland CL, Tzeng CD, Chun YS, Feig BW, Vauthey JN, Conrad C. Long-term survival according to histology and radiologic response to preoperative chemotherapy in 126 patients undergoing resection of non-GIST sarcoma liver metastases. Ann Surg Oncol 25(1):107-116, 2018. e-Pub 2017. PMID: 29116489.
- Omichi K, Shindoh J, Cloyd JM, Mizuno T, Chun YS, Conrad C, Aloia TA, Tzeng CD, Vauthey JN. Liver resection is justified for patients with bilateral multiple colorectal liver metastases: A propensity-score-matched analysis. Eur J Surg Oncol 44(1):122-129, 2018. e-Pub 2017.
- Omichi K, Mizuno T, Okuno M, Tzeng CD, Conrad C, Chun YS, Aloia TA, Vauthey JN. Long term outcome after resection of liver metastases from squamous cell carcinoma. Eur J Surg Oncol 43(11):2129-2134, 2017. e-Pub 2017. PMID: 28958732.
- Omichi K, Cloyd JM, Yamashita S, Tzeng CWD, Conrad C, Chun YS, Aloia TA, Vauthey JN. Neutrophil-to-lymphocyte ratio predicts prognosis following neoadjuvant chemotherapy and resection of intrahepatic cholangiocarcinoma. Surgery 162(4):752-765, 2017. e-Pub 2017. PMID: 28688518.
- Yamashita S, Venkatesan AM, Mizuno T, Aloia TA, Chun YS, Lee JE, Vauthey JN, Conrad C. Remnant liver ischemia as a prognostic factor for cancer-specific Survival after resection of colorectal liver metastases. JAMA Surg 18(152):10, 2017. e-Pub 2017. PMID: 28854316.
- Patel SH, Kim BJ, Tzeng CD, Chun YS, Conrad C, Vauthey JN, Aloia TA. Reduction of cardiopulmonary/renal complications with serum BNP-guided volume status management in posthepatectomy patients. J Gastrointest Surg 22(3):467-476. e-Pub 2017. PMID: 29234998.
- Aloia TA, Kim BJ, Chun YS, Cata JP, Truty MJ, Shi Q, Holmes A, Soliz JM, Popat KU, Rahlfs TF, Lee JE, Wang XS, Morris JS, Gottumukkala VNR, Vauthey JN. A randomized controlled trial of postoperative thoracic epidural analgesia versus intravenous patient-controlled analgesia after major hepatopancreatobiliary surgery. Ann Surg 266(3):545-554, 2017.
- Vinuela E, Vega EA, Yamashita S, Sanhueza M, Mege R, Cavada G, Aloia TA, Chun YS, Lee JE, Vauthey JN, Conrad C. Incidental gallbladder cancer: Residual cancer discovered at oncologic extended resection determines outcome: A report from high- and low-Incidence countries. Ann Surg Oncol 24(8):2334-2343, 2017. e-Pub 2017. PMID: 28417239.
- Odisio BC, Yamashita S, Frota L, Huang SY, Kopetz SE, Ahrar K, Chun YS, Aloia TA, Hicks ME, Gupta S, Vauthey JN. Planned treatment of advanced metastatic disease with completion ablation after hepatic resection. J Gastrointest Surg 21(4):628-635, 2017. e-Pub 2016. PMID: 27882510.
- Vega EA, Yamashita S, Chun YS, Kim M, Fleming JB, Katz MH, Tzeng CW, Raghav KP, Vauthey JN, Lee JE, Conrad C. Effective laparoscopic management lymph node dissection for gallbladder cancer. Ann Surg Oncol 24(7):1852, 2017. e-Pub 2017. PMID: 28168387.
- Al-Shamsi HO, Abdel-Wahab R, Hassan MM, Shalaby AS, Dahbour I, Lacin S, Mahvash A, Odisio BC, Murthy R, Avritscher R, Abdelsalam ME, Rashid A, Vauthey JN, Aloia TA, Conrad C, Chun YS, Krishnan S, Das P, Koay EJ, Amin HM, Yao JC, Kaseb AO. Natural history of T1N0M0 hepatocellular carcinoma: large-scale study in the United States. Oncology 93(4):233-242. e-Pub 2017. PMID: 28683459.
- Yamashita S, Odisio BC, Huang SY, Kopetz SE, Ahrar K, Chun YS, Conrad C, Aloia TA, Gupta S, Harmoush S, Hicks ME, Vauthey JN. Embryonic origin of primary colon cancer predicts survival in patients undergoing ablation for colorectal liver metastases. Eur J Surg Oncol 43(6):1040-1049, 2017. e-Pub 2017. PMID: 28187878.
- Holliday EB, Tao R, Brownlee Z, Das P, Krishnan S, Taniguchi C, Minsky BD, Herman JM, Kaseb A, Raghav K, Conrad C, Vauthey JN, Aloia TA, Chun YS, Crane CH, Koay EJ. Definitive radiation therapy for hepatocellular carcinoma with portal vein tumor thrombus. Clin Transl Radiat Oncol 4:39-45, 2017.
- Yamashita S, Loyer E, Kang HC, Aloia TA, Chun YS, Mehran RJ, Eng C, Lee JE, Vauthey JN, Conrad C.. Total transthoracic approach facilitates laparoscopic hepatic resection in patients with significant prior abdominal surgery. Ann Surg Oncol 24(5):1376-1377, 2017. e-Pub 2016. PMID: 27878479.
- Kutlu OC, Chan JA, Aloia TA, Chun YS, Kaseb AO, Passot G, Yamashita S, Vauthey JN, Conrad C. Comparative effectiveness of first-line radiofrequency ablation versus surgical resection and transplantation for patients with early hepatocellular carcinoma. Cancer 123(10):1817-1827, 2017. e-Pub 2017. PMID: 28085184.
- Odisio BC, Yamashita S, Huang SY, Harmoush S, Kopetz SE, Ahrar K, Chun YS, Conrad C, Aloia TA, Gupta S, Hicks ME, Vauthey JN. Local tumour progression after percutaneous ablation of colorectal liver metastases according to RAS mutation status. Br J Surg 104(6):760-768, 2017. e-Pub 2017.
- Mizuno T, Sheth R, Yamamoto M, Kang HS, Yamashita S, Aloia TA, Chun YS, Lee JE, Vauthey JN, Conrad C. Laparoscopic Glissonean pedicle transection (TAKASAKI) for negative fluorescent counterstaining of segment 6. Ann Surg Oncol 24(4):1046-1047, 2017. e-Pub 2016. PMID: 27995453.
- Yamashita S, Koay EJ, Passot G, Shroff R, Raghav KP, Conrad C, Chun YS, Aloia TA, Tao R, Kaseb A, Javle M, Crane CH, Vauthey JN. Local therapy reduces the risk of liver failure and improves survival in patients with intrahepatic cholangiocarcinoma: A comprehensive analysis of 362 consecutive patients. Cancer 123(8):1354-1362, 2017. e-Pub 2016.
- Passot G, Denbo JW, Yamashita S, Kopetz SE, Chun YS, Maru D, Overman MJ, Brudvik KW, Conrad C, Aloia TA, Vauthey JN. Is hepatectomy justified for patients with RAS mutant colorectal liver metastases? An analysis of 524 patients undergoing curative liver resection. Surgery 161(2):332-340, 2017. e-Pub 2016. PMID: 27592215.
- Yamashita S, Passot G, Aloia TA, Chun YS, Javle M, Lee JE, Vauthey JN, Conrad C. Prognostic value of carbohydrate antigen 19-9 in patients undergoing resection of biliary tract cancer. Br J Surg 104(3):267-277, 2017. e-Pub 2017. PMID: 28052308.
- Denbo JW, Yamashita S, Passot G, Egger M, Chun YS, Kopetz SE, Maru D, Brudvik KW, Wei SH, Conrad C, Vauthey JN, Aloia TA. RAS mutation is associated with decreased survival in patients undergoing repeat hepatectomy for colorectal liver metastases. J Gastrointest Surg 21(1):68-77, 2017. e-Pub 2016. PMID: 27334313.
- Yamashita S, Loyer E, Chun YS, Javle M, Lee JE, Vauthey JN, Conrad C. Laparoscopic management of gallbladder cancer: A stepwise approach. Ann Surg Oncol 23(Suppl 5):892-893, 2016. e-Pub 2016. PMID: 27456958.
- Yamashita S, Vauthey JN, Kaseb AO, Aloia TA, Conrad C, Hassan MM, Passot G, Raghav KP, Shama MA, Chun YS. Prognosis of fibrolamellar carcinoma compared to non-cirrhotic conventional hepatocellular carcinoma. J Gastrointest Surg 20(10):1725-31, 2016. e-Pub 2016. PMID: 27456016.
- Passot G, Chun YS, Kopetz SE, Overman MJ, Conrad C, Aloia TA, Vauthey JN. Prognostic factors after resection of colorectal liver metastases following preoperative second-line chemotherapy: Impact of RAS mutations. Eur J Surg Oncol 42(9):1378-84, 2016. e-Pub 2016.
- Brudvik K, Mise Y, Chung MH, Chun YS, Kopetz SE, Passot G, Conrad C, Maru D, Aloia TA, Vauthey JN. RAS mutation predicts positive resection margins and narrower resection margins in patients undergoing resection of colorectal liver metastases. Ann Surg Oncol 23(8):2635-43, 2016. e-Pub 2016.
- Passot G, Chun YS, Kopetz SE, Zorzi D, Brudvik KW, Kim BJ, Conrad C, Aloia TA, Vauthey JN. Predictors of safety and efficacy of 2-stage hepatectomy for bilateral colorectal liver metastases. J Am Coll Surg 223(1):99-108, 2016. e-Pub 2016.
- Passot G, Odisio BC, Zorzi D, Mahvash A, Gupta S, Wallace MJ, Kim BJ, Yamashita S, Conrad C, Aloia TA, Vauthey JN, Chun YS. Eradication of missing liver metastases after fiducial placement. J Gastrointest Surg 20(6):1173-8, 2016. e-Pub 2016. PMID: 26791387.
- Conrad C, Passot G, Katz MH, Fleming JB, Kim M, Chun YS, Aloia TA, Vauthey JN, Lee JE. Laparoscopic insulinoma enucleation from the retro-pancreatic neck: A stepwise approach. Ann Surg Oncol 23(6):2001, 2016. e-Pub 2016. PMID: 26960928.
- Chun YS, Parker RJ, Inampudi S, Ehrenwald E, Batts KP, Burgart LJ, Schumacher CW, Mehling JA, Engstrom BI, Hill MJ, Reddy SK, Sielaff TD. Imaging surveillance of hypervascular liver lesions in non-cirrhotic patients. J Gastrointest Surg 20(3):564-7, 2016. e-Pub 2015. PMID: 26376993.
- Day RW, Brudvik KW, Vauthey JN, Conrad C, Gottumukkala V, Chun YS, Katz MH, Fleming JB, Lee JE, Aloia TA.. Advances in hepatectomy technique: Toward zero transfusions in the modern era of liver surgery. Surgery 159(3):793-801, 2016. e-Pub 2015. PMID: 26584854.
- Fang S, Wang Y, Chun YS, Liu H, Ross MI, Gershenwald JE, Cormier JN, Royal RE, Lucci A, Schacherer CW, Reveille JD, Chen W, Sui D, Bassett RL, Wang LE, Wei Q, Amos CI, Lee JE. Association of common genetic polymorphisms with melanoma patient il-12p40 blood levels, risk, and outcomes. J Invest Dermatol 135(9):2266-2272, 2015. e-Pub 2015.
- Fang S, Wang Y, Chun YS, Liu H, Ross MI, Gershenwald JE, Cormier JN, Royal RE, Lucci A, Schacherer CW, Reveille JD, Sui D, Bassett RL, Wang LE, Wei Q, Amos CI, Lee JE. The relationship between blood IL-12p40 level and melanoma progression. Int J Cancer 136(8):1874-80, 2015. e-Pub 2014. PMID: 25196740.
- Chun YS, Huang M, Rink L, Von Mehren M. Expression levels of insulin-like growth factors and receptors in hepatocellular carcinoma: a retrospective study. World J Surg Oncol 22(12):231, 2014. PMID: 25052889.
- Papavasiliou P, Hoffman JP, Cohen SJ, Meyer JE, Watson JC, Chun YS. Impact of preoperative therapy on patterns of recurrence in pancreatic cancer. HPB (Oxford) 16(1):34-9, 2014. e-Pub 2013. PMID: 23458131.
- Thomay AA, Nagorney DM, Cohen SJ, Sigurdson ER, Truty MJ, Burtness B, Hall MJ, Chun YS. Modern chemotherapy mitigates adverse prognostic effect of regional nodal metastases in stage IV colorectal cancer. J Gastrointest Surg 18(1):69-74, 2014. e-Pub 2013. PMID: 24002765.
- Shindoh J, Loyer EM, Kopetz S, Boonsirikamchai P, Maru DM, Chun YS, Zimmitti G, Curley SA, Charnsangavej C, Aloia TA, Vauthey JN. Optimal morphologic response to preoperative chemotherapy: an alternate outcome end point before resection of hepatic colorectal metastases. J Clin Oncol 30(36):4566-72, 2012. e-Pub 2012. PMID: 23150701.
- Papavasiliou P, Arrangoiz R, Zhu F, Chun YS, Edwards K, Hoffman JP. The anatomic course of the first jejunal branch of the superior mesenteric vein in relation to the superior mesenteric artery. Int J Surg Oncol(2090-1402):538769, 2012. e-Pub 2012.
- Chun YS, Cooper HS, Cohen SJ, Konski A, Burtness B, Denlinger CS, Astsaturov I, Hall MJ, Hoffman JP. Significance of pathologic response to preoperative therapy in pancreatic cancer. Ann Surg Oncol 18(13):3601-7, 2011. PMID: 21947697.
- Adusumilli PS, Gholami S, Chun YS, Mullerad M, Chan MK, Yu Z, Ben-Porat L, Rusch VW, Fong Y. Fluorescence-assisted cytological testing (FACT): Ex Vivo viral method for enhancing detection of rare cancer cells in body fluids. Mol Med 17(7-8):628-34, 2011. PMID: 21487639.
- Chun YS, Milestone BN, Watson JC, Cohen SJ, Burtness B, Engstrom PF, Haluszka O, Tokar JL, Hall MJ, Denlinger CS, Astsaturov I, Hoffman JP. Defining venous involvement in borderline resectable pancreatic cancer. Ann Surg Oncol 17(11):2832-8, 2010. PMID: 20725860.
- Maru DM, Kopetz S, Boonsirikamchai P, Agarwal A, Chun YS, Wang H, Abdalla EK, Kaur H, Charnsangavej C, Vauthey JN, Loyer EM. Tumor thickness at the tumor-normal interface: a novel pathologic indicator of chemotherapy response in hepatic colorectal metastases. Am J Surg Pathol 34(9):1287-94, 2010. PMID: 20697255.
- Palavecino M, Kishi Y, Chun YS, Brown DL, Gottumukkala VN, Lichtiger B, Curley SA, Abdalla EK, Vauthey JN. Two-surgeon technique of parenchymal transection contributes to reduced transfusion rate in patients undergoing major hepatectomy: analysis of 1,557 consecutive liver resections. Surgery 147(1):40-8, 2010. PMID: 19733879.
- Chun YS, Vauthey JN, Boonsirikamchai P, Maru DM, Kopetz S, Palavecino M, Curley SA, Abdalla EK, Kaur H, Charnsangavej C, Loyer EM. Association of computed tomography morphologic criteria with pathologic response and survival in patients treated with bevacizumab for colorectal liver metastases. JAMA 302(21):2338-44, 2009. PMID: 19952320.
- Kishi Y, Abdalla EK, Chun YS, Zorzi D, Madoff DC, Wallace MJ, Curley SA, Vauthey JN. Three hundred and one consecutive extended right hepatectomies: evaluation of outcome based on systematic liver volumetry. Ann Surg 250(4):540-8, 2009. PMID: 19730239.
- Palavecino M, Chun YS, Madoff DC, Zorzi D, Kishi Y, Kaseb AO, Curley SA, Abdalla EK, Vauthey JN. Major hepatic resection for hepatocellular carcinoma with or without portal vein embolization: Perioperative outcome and survival. Surgery 145(4):399-405, 2009. PMID: 19303988.
- Kishi Y, Kopetz S, Chun YS, Palavecino M, Abdalla EK, Vauthey JN. Blood neutrophil-to-lymphocyte ratio predicts survival in patients with colorectal liver metastases treated with systemic chemotherapy. Ann Surg Oncol 16(3):614-22, 2009. PMID: 19130139.
- Kishi Y, Madoff DC, Abdalla EK, Palavecino M, Ribero D, Chun YS, Vauthey JN. Is embolization of segment 4 portal veins before extended right hepatectomy justified?. Surgery 144(5):744-51, 2008. PMID: 19081016.
- Blazer DG, Kishi Y, Maru DM, Kopetz S, Chun YS, Overman MJ, Fogelman D, Eng C, Chang DZ, Wang H, Zorzi D, Ribero D, Ellis LM, Glover KY, Wolff RA, Curley SA, Abdalla EK, Vauthey JN. Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases. J Clin Oncol 26(33):5344-51, 2008. PMID: 18936472.
- Zorzi D, Chun YS, Madoff DC, Abdalla EK, Vauthey JN. Chemotherapy with bevacizumab does not affect liver regeneration after portal vein embolization in the treatment of colorectal liver metastases. Ann Surg Oncol 15(10):2765-72, 2008. PMID: 18636296.
- Woo Y, Kelly KJ, Stanford MM, Galanis C, Chun YS, Fong Y, McFadden G. Myxoma virus is oncolytic for human pancreatic adenocarcinoma cells. Ann Surg Oncol 15(8):2329-35, 2008. PMID: 18454298.
- Riedl CC, Brader P, Zanzonico PB, Chun YS, Woo Y, Singh P, Carlin S, Wen B, Ling CC, Hricak H, Fong Y. Imaging hypoxia in orthotopic rat liver tumors with iodine 124-labeled iodoazomycin galactopyranoside PET. Radiology 248(2):561-70, 2008. PMID: 18641253.
- Chun YS, Ribero D, Abdalla EK, Madoff DC, Mortenson MM, Wei SH, Vauthey JN. Comparison of two methods of future liver remnant volume measurement. J Gastrointest Surg 12(1):123-8, 2008. PMID: 17924174.
- Chun YS, Vauthey JN, Ribero D, Donadon M, Mullen JT, Eng C, Madoff DC, Chang DZ, Ho L, Kopetz S, Wei SH, Curley SA, Abdalla EK. Systemic chemotherapy and two-stage hepatectomy for extensive bilateral colorectal liver metastases: perioperative safety and survival. J Gastrointest Surg 11(11):1498-504; discussion 1504-5, 2007. PMID: 17849166.
- Iqbal CW, Chun YS, Farley DR. Colonoscopic perforations: a retrospective review. J Gastrointest Surg 9(9):1229-35: discussion 1236, 2005. PMID: 16332478.
- Adusumilli PS, Eisenberg DP, Chun YS, Ryu KW, Ben-Porat L, Hendershott KJ, Chan MK, Huq R, Riedl CC, Fong Y. Virally directed fluorescent imaging improves diagnostic sensitivity in the detection of minimal residual disease after potentially curative cytoreductive surgery. J Gastrointest Surg 9(8):1138-46; discussion 1146-7, 2005. PMID: 16269385.
- Chun YS, Adusumilli PS, Fong Y. Employing tumor hypoxia for oncolytic therapy in breast cancer. J Mammary Gland Biol Neoplasia 10(4):311-8, 2005. PMID: 16826462.
- Chun YS, Lindor NM, Smyrk TC, Petersen BT, Burgart LJ, Guilford PJ, Donohue JH. Germline E-cadherin gene mutations: is prophylactic total gastrectomy indicated?. Cancer 92(1):181-7, 2001. PMID: 11443625.
Invited Articles
- Lee AJ, Chun YS. Intrahepatic Cholangiocarcinoma: The AJCC/UICC 8th Edition Updates. Chin Clin Oncol 7(5):52, 2018. PMID: 30180751.
- Chun YS, Pawlik TM, Vauthey JN. 8th Edition of the AJCC cancer staging manual: pancreas and hepatobiliary cancers. Ann Surg Oncol 25(4):845-847, 2018. PMID: 28752469.
- Lam M, Loree JM, Pereira AAL, Chun YS, Kopetz S. Accelerating therapeutic development through innovative trial design in colorectal cancer. Curr Treat Options Oncol 19(2):11, 2018. PMID: 29488033.
- Chun YS. Role of radical antegrade modular pancreatosplenectomy (RAMPS) and pancreatic cancer. Ann Surg Onc 25(1):46-50, 2018. PMID: 27848048.
- Chun YS, Javle M. Systemic and adjuvant therapies for intrahepatic cholangiocarcinoma. Cancer Control 24(3):1-7, 2017. PMID: 28975832.
- Torzilli G, Nagino M, Tzeng CW, Kingham TP, Alatise OI, Ayandipo B, Yamashita S, Arrington AK, Kim J, Chun YS, Vauthey JN. SSAT state-of-the-art conference: new frontiers in liver surgery. J Gastrointest Surg 21(1):175-185, 2017. PMID: 27480411.
- Shindoh J, Chun YS, Loyer EM, Vauthey JN. Non-size-based response criteria to preoperative chemotherapy in patients with colorectal liver metastases: the morphologic response criteria. Curr Colorectal Cancer Rep 9(2):198-202, 2013. PMID: 23710157.
- Papavasiliou P, Chun YS, Hoffman JP. How to define and manage borderline resectable pancreatic cancer. Surg Clin North Am 93(3):663-674, 2013. PMID: 23632151.
- Chun YS, House MG, Kaur H, Loyer EM, Paradis V, Vauthey JN. SSAT/AHPBA joint symposium on evaluation and treatment of benign liver lesions. J Gastrointest Surg 17(4):636-44, 2013. PMID: 23377783.
- Abdalla EK, Bauer TW, Chun YS, D'Angelica M, Kooby DA, Jarnagin WR. Locoregional surgical and interventional therapies for advanced colorectal cancer liver metastases: expert consensus statements. HPB (Oxford) 15(2):119-30, 2013.
- Chun YS, Zimmitti G. Fibrolamellar variant of hepatocellular carcinoma. Recent Results Cancer Res 190:101-110, 2013. PMID: 22941016.
- Chun YS, Laurent A, Maru D, Vauthey JN. Management of chemotherapy-associated hepatotoxicity in colorectal liver metastases. Lancet Oncol 10(3):278-86, 2009. PMID: 19261256.
- Chun YS, Vauthey JN. Risks of neoadjuvant chemotherapy for resectable colorectal carcinoma hepatic metastases. Curr Colorectal Cancer Rep(4):87-92, 2008.
- Ribero D, Chun YS, Vauthey JN. Standardized liver volumetry for portal vein embolization. Semin Intervent Radiol 25(2):104-9, 2008. PMID: 21326551.
- Mazzaferro V, Chun YS, Poon RT, Schwartz ME, Yao FY, Marsh JW, Bhoori S, Lee SG. Liver transplantation for hepatocellular carcinoma. Ann Surg Oncol 15(4):1001-7, 2008.
- Chun YS Vauthey JN. Extending the frontiers of resectability in advanced colorectal cancer. Eur J Surg Oncol 33 Suppl 2:S52-8, 2007. PMID: 18006265.
Other Articles
- Chun YS, Calderaro J, Zucman-Rossi J Synchronous hepatocellular carcinoma and Castleman's disease: the role of the interleukin-6-signaling pathway. Hepatology 56(1):392-3, 2012. PMID: 22611056.
- Chun YS, Robu VG Spectrum of primary vascular neoplasms of the spleen. J Clin Oncol 29(5):e116-7, 2011. PMID: 21115874.
- Chun YS, Cherry KJ Radiation arteritis. J Am Coll Surg 196(3):482, 2003. PMID: 12648702.
Editorials
- Chun YS, Vauthey JN. Local therapy for colorectal liver metastases: Establishing today's level of evidence and defining tomorrow's roadmap. J Natl Cancer Inst(109):9, 2017. PMID: 28376150.
Abstracts
- Simoneau E, Chun YS, Karpinets T, Zhan J, Song X, Javle M, Shroff R, Futreal A, Vauthey JN, Estrella J. Genomic profiling of intrahepatic metastases versus localized satellites in intrahepatic cholangiocarcinoma. Ann Surg Oncol 25(Suppl 1):S24, 2018.
- Goumard C, You Y, Okuno M, Vega Pizzaro EA, Simoneau E, Aloia T, Chun YS, Tzeng C, Raghav K, Vauthey J, Conrad C. Impact of postoperative complications on return to intended oncologic treatment and survival in patients undergoing resection for rectal cancer with synchronous liver metastases. Ann Surg Oncol 25(Suppl. 1):S135, 2018.
- Vicente D, Mizuno T, Loehrer A, Limani P, Royal RE, Fournier K, Chun YS, Conrad C, Tzeng C, Kopetz S, Aloia T, Vauthey J. SMAD4 gene mutation is associated with higher incidence of peritoneal involvement in unresectable metastatic colorectal cancer. Ann Surg Oncol 25(Suppl. 1):S166, 2018.
- Cloyd J, Tzeng C, Mizuno T, Conrad C, Omichi K, Aloia T, Vauthey J, Chun YS. BRAF mutation is not a contraindication to resection of colorectal liver metastases. HPB 19:S55-S56, 2017.
- Denbo J, Kim B, Vauthey J, Conrad C, Ma J, Chun YS, Katz M, Aloia T. Overall body composition and sarcopenia are associated with poor liver regeneration following portal vein embolization. HPB 19(Suppl 1):S20, 2017.
- Patel S, Kim B, Tzeng C, Chun YS, Conrad C, Vauthey J, Aloia T. Reduction of cardiopulmonary/renal complications with serum brain natriuretic peptide-guided volume status management in post hepatectomy patients. HPB 19:S29, 2017.
- Yamashita S, Omichi K, Conrad C, Chun YS, Aloia TA, Vauthey JN, Tzeng CWD. Portal vein embolization reduces postoperative hepatic insufficiency associated with hepatic atrophy caused by extensive chemotherapy. Gastroenterology 152(Supp 1):5, 2017.
- Mizuno T, Sheth R, Yamamoto M, Kang H, Yamashita S, Aloia TA, Chun YS, Lee JE, Vauthey JN, Conrad C. Laparoscopic glissonean pedicle transection method (TAKASAKI) for negative fluorescent counterstaining of segment 6. HPB 19:S114, 2017.
- Cloyd JM, Chun YS, Denbo J, Javle M, Shroff R, Vauthey JN, Aloia T, Cuddy A, Rodriguez-Bigas MA, You N. Long-term survival among mismatch repair deficient cholangiocarcinomas associated with lynch syndrome. Gastroenterology 152(Supp 1):5: S-1254, 2017.
- Kim B, Denbo J, Davis C, Chun YS, Vauthey JN, Tzeng CW, Aloia T. For patients with hepatocellular carcinoma, perioperative transfusion is a co-variate for short-term morbidity and mortality but does not impact long-term oncologic outcomes. Gastroenterology 152(5):S1255, 2017.
- Amer AM, Tao R, Kang H, Chun YS, Vauthey JN, Javle MM, Kaseb AO, Crane CH, Koay EJ. Quantitative european association for the study of the liver (qEASL) as an early biomarker of response after radiation therapy for intrahepatic cholangiocarcinoma. Int J Radiat Oncol Biol Phys 96(2S):S202, 2016. PMID: 27675783.
- Conrad C, Passot G, Katz MHG, Fleming JB, Kim MP, Chun YS, Aloia TA, Vauthey JN, Lee JE. Laparoscopic insulinoma enucleation from the retro-pancreatic neck: A stepwise approach. Ann Surg Oncol 23(6):2001, 2016. e-Pub 2016. PMID: 26960928.
- Conrad C, Weissinger D, Shiozaki H, Aloia TA, Bednarski B, Messick CA, Chun YS, Vauthey JN. Coordinated minimally invasive multi-stage surgery for stage IV colorectal cancer. Ann Surg Oncol 23(Suppl. 1):S110, 2016.
- Phuoc V, Chun YS, Vauthey JN, Newhook T, Conrad C, Aloia TA, Kang H, Yedururi S, Loyer EM. Radiographic predictors of intrahepatic recurrence after resection of colorectal liver metastases. Ann Surg Oncol 23(Suppl. 1):S116, 2016.
- Yamashita S, Chun YS, Passot G, Conrad C, Aloia TA, Shma MA, Raghav K, Hassan M, Kaseb A, Vauthey JN. Prognosis of fibrolamellar carcinoma compared to non-cirrhotic conventional hepatocellular carcinoma. Gastroenterology 150(Suppl. 1):S1188, 2016.
- Patel SH, Kim B, Chun YS, Conrad C, Vauthey JN, Aloia T. Serum brain natriuretic peptide in the perioperative management of volume status in patients post hepatectomy. HPB 18:e597-8, 2016.
- Denbo J, Passot G, Chun YS, Yamashita S, Kopetz S, Maru D, Brudvik KW, Wei S, Conrad C, Aloia T, Vauthey JN. RAS mutation status impacts survival in patients undergoing repeat hepatectomy for colorectal liver metastases. Gastroenterology 150(Suppl. 1):S1174, 2016.
- Chun YS, Parker RJ, Reddy SK, Ehrenwald E, Hill MJ, Inampudi S, Sielaff TD.. Imaging surveillance of hepatocellular adenomas. HPB 17(Suppl. 1):25, 2015.
- Chun YS, Reddy SK, Leach J, Inampudi S, Ehrenwald E, Sielaff T. Synergistic effects of radioembolization and ipilimumab in metastatic melanoma to the liver. Gastroenterology 148:S-1181, 2015.
- Thomay AA, Hoffman JP, Chun YS. Defining resection margins in pancreatic cancer after neoadjuvant chemoradiotherapy. Gastroenterology 142(Suppl. 1):S1062-S1063, 2012.
- Papavasiliou P, Arrangoiz R, Milestone BN, Hoffman JP, Chun YS. Computed tomographic assessment of resectability after neoadjuvant therapy in pancreatic cancer. Ann Surg Oncol 18(Suppl. 1):S83, 2011.
- Siripurapu V, Papavasiliou P, Denlinger CS, Hoffman JP, Chun YS. The AJCC staging system for hepatocelluar carcinoma predicts survival in medically treated western patients. HPB 13(Suppl. 1):64, 2011.
- Chun YS, Kopetz S, Palavecino M, Zorzi D, Curley SA, Abdalla EK, Vauthey JN. Proposal of new staging in advanced colorectal cancer. Ann Surg Oncol 16(Suppl. 1):28, 2009.
- Chun YS, Abdalla EK, Zorzi D, Breaux JA, Vauthey JN. Liver hanging maneuver improves the outcomes of complex right upper quadrant resections. HPB 11(Suppl. 1):76-77, 2009.
Book Chapters
- Lacin S, Rashid A, Chun YS, Odisio BC, Koay EJ, Abdel-Wahab A, Kaseb AO. Hepatocellular carcinoma. In: Textbook of Gastrointestinal Oncology. Springer Cham: Switzerland, 207-234, 2019.
- Nagorney DM, Pawlik TM, Chun YS, Ebata T, Vauthey JN. Perihilar bile ducts. In: AJCC Cancer Staging Manual, Eighth Edition. Springer International Publishing: Switzerland, 311-316, 2016.
- Chun YS, Tsai S. Key question: distal pancreatectomy. In: Operative Standards for Cancer Surgery. Wolters Kluwer: Philadelphia, 253-259, 2015.
- Chun YS. Multidisciplinary management of recurrent colorectal cancer: potentially resectable/curable disease: liver. In: Cancers of the Colon and Rectum: A Multidisciplinary Approach to Diagnosis and Management. Demos Medical Publishing: New York, 175-196, 2013.
- Chun YS, Vauthey JN. History of major liver resections. In: Venous Embolization of the Liver: Radiologic and Surgical Practice. Springer-Verlag: New York, 3-8, 2011.
- Zorzi D, Chun YS, Vauthey JN. Liver resection of colorectal liver metastases. In: Malignant Liver Tumors, Current and Emerging Therapies, 3rd Edition. Wiley-Blackwell: Oxford, UK, 192-202, 2010.
- Vauthey JN, Pawlik TM, Abdalla EK, Aloia TA, Boudreaux CS, Chun YS, Dixon E, Fong Y, Kooby D, Lauwers GY, Mayo MS, Nagorney DM, Lombardo KR, Taouli B, Washington MK, Wittenkind C, Wu TT, Zhu A. Hepatobiliary staging chapters. In: AJCC Cancer Staging Manual, Seventh Edition. Springer International Publishing: New York, 191-249, 2010.
- Ribero D, Chun YS, Vauthey JN. Surgery for colorectal metastases. In: Liver Metastases. Springer-Verlag: London, 25-38, 2009.
- Kendrick ML, Chun YS, Christein JD, Sarr MG. Surgical palliation of pancreatic cancer. In: Pancreatic Cancer. Barlett Publishers: Boston, 435-446, 2005.
Grant & Contract Support
| Title: | The University of Texas MD Anderson Cancer Center SPORE in Hepatocellular Carcinoma |
| Funding Source: | NIH/NCI |
| Role: | Core Leader |
| Title: | Development and Validation of Prognostic Radiomic Markers of Response and Recurrence for Patients with Colorectal Liver Metastases |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
Patient Reviews
CV information above last modified December 18, 2024