
Zahid Hussain Siddik, Ph.D.
Department of Experimental Therapeutics, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Professor of Medicine (Pharmacology), Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor of Medicine (Pharmacology), Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX
Member, Graduate School of Biomedical Sciences (GSBS), Houston, TX
Research Interests
Presence of wild-type p53 is prevalent in many refractory cancers. My current interests are focused on understanding how drug resistance is induced when wild-type p53 is present and how such a mechanism can be circumvented through drug design. More specifically, we are focused on the dysfunctionality of the p53/p21 pathway and how it impacts apoptosis through loss of checkpoint response.
Education & Training
Degree-Granting Education
1975 | University of London, London, US, Biochemistry, Ph.D |
1972 | University of Liverpool, Liverpool, GB, Biochemistry, BS |
Postgraduate Training
1976-1980 | Fogarty Postdoctoral Fellow, Laboratory of Toxicology, Drug Interactions Section, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland |
1972-1975 | Postgraduate Student, St. Mary's Hospital Medical School, Paddington, London W2 1PG |
Experience & Service
Academic Appointments
Adjunct Professor, Department of Pharmacology, University of Houston, Houston, TX, 1988 - 1999
Associate Professor of Medicine (Pharmacology) and Associate Pharmacologist, Department of Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1987 - 1995
Staff Scientist and Leader, Department of Dept. of Biochemical Pharmacology, The Institute of Cancer Research, University of London, Belmont, Sutton SM2 5PX, Surrey, 1984 - 1987
Research Scientist, Department of Dept. of Biochemical Pharmacology, The Institute of Cancer Research, University of London, Belmont, Sutton SM2 5PX, Surrey, 1980 - 1984
Administrative Appointments/Responsibilities
Chairman (ad interim), Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1999 - 2003
Other Appointments/Responsibilities
Consultantships, OncoTEX Inc, New York, NY, 2020 - Present
Consultantships, Valent Technologies LLC, Menlo,CA, 2017 - 2019
Director, Mentoring Program, Department of Experimental Therapeutics, Houston, TX, 2013 - Present
Consultantships, King Fahd University of Petroleum & Minerals, Saudi Arabia, 2010 - 2016
Consultantships, XenoPort, Inc, San Jose, CA, 2005 - 2016
Consultantships, Alkermes, Inc, Cambridge, MA, 1995 - 1998
Drug Development Program, Institute of Cancer Research, Department of Biochemical Pharmacology, Sutton, Surrey, England, 1987 - 1989
Institutional Committee Activities
Member, Institutional Faculty Senate, 2021 - Present
Ex Officio Member, Faculty Senate Election Committee, 2020 - 2020
Member, Search Committee, Chair of the Department of Comparative Medicine, 2019 - 2020
Member, MD Anderson Graduate Education Committee, 2019 - Present
Member, Institutional Decision Maker Conflict of Interest Committee, 2019 - Present
Member, Faculty Senate Institutional Policy Review Committee, 2019 - 2020
Member, Institutional Bridge Funding Committee, 2018 - Present
Member, PRS Compensation Committee, 2018 - 2019
Member, Institutional Historical Resources Center (HRC) Steering Committee, 2018 - 2021
Member, Faculty Senate Research Endowment Committee, 2017 - 2020
Member, Institutional Executive Committee of the Faculty Senate, 2016 - 2020
Selection Committee, Alfred G. Knudson, Jr. Outstanding Dissertation Award, 2015 - 2016
Member, Institutional Faculty Senate Byelaws Committee, 2014 - Present
Chair, Institutional Faculty Senate Byelaws Committee, 2014 - 2020
Chair, Faculty Achievement Awards Committee, 2014 - 2018
Director, Mentoring Program, Department of Experimental Therapeutics, 2013 - Present
Selection Committee, Alfred G. Knudson, Jr. Outstanding Dissertation Award, 2013 - 2014
Member, Faculty Achievement Awards Committee, 2013 - 2019
Member, Institutional Faculty Senate, 2012 - 2020
Member, Institutional Faculty Senate Compensation Committee, 2010 - 2011
Chairman, Benvenuto Memorial Award Lecture Committee, 2007 - Present
Chairman, Seminar Organization Committee Department of Experimental Therapeutics, 2007 - 2013
Member, Institutional Faculty Senate, 2005 - 2011
Member, Faculty Health Committee, 2004 - 2007
Member, Faculty Compensation Committee, 2004 - 2006
Member, Seminar Organization Committee, Department of Experimental Therapeutics, 2004 - Present
Chairman, Faculty Compensation Committee, 2004 - 2006
Member, Technology Champions Project Team, 2003 - 2007
Member, Institutional Communication Advisory Committee, 2003 - 2011
Member, Chaplaincy Advisory Committee, 2002 - 2002
Member, Pharmaceutical Development Center Users Committee, 2002 - 2003
Member, Executive Committee of the Science Faculty, 2001 - 2003
Member, Faculty Compensation Sub-Committee, 2001 - 2004
Chairman, Faculty Compensation Sub-Committee, 2001 - 2004
Chairman, Term Appointment Committee for Non-Tenured Faculty, 2001 - 2001
Member, GSBS Academic Standards Committee, 2000 - 2003
Member, Leadership Steering Committee, Division of Cancer Medicine, 2000 - 2001
Member, OPR Research Integrity ad hoc Committee, 2000 - 2000
Member, Search Committee, Head of the Division of Diagnostic Imaging, 2000 - 2000
Member, Oversight Committee: Cancer Therapeutics Discovery Program and Pharmaceutical Development Center, 2000 - 2002
Member, Intellectual Property Oversight Committee, 2000 - 2003
Member, Diversity Council, 2000 - 2004
Member, Term Appointment Committee for Non-Tenured Faculty, 2000 - 2002
Reviewer, Cancer Therapeutics Discovery Program Grant, 2000 - 2003
Member, Faculty Advisory Committee for the New Institutional Grants Program, 1999 - 2005
Member, OPR Scientific Advisory Committee, 1999 - 2009
Member, Odyssey Postdoctoral Program Review Committee, 1999 - 2006
Member, Research Council Subcommittee: New CCSG Shared Resource Requests, 1999 - 2003
Member, Research Funding Oversight Committee, 1999 - 2009
Member, Division of Cancer Medicine Executive Council, 1999 - 2003
Chairman, Institutional Biosafety Committee, 1999 - Present
Chairman, Faculty Senate Salary Review Committee, 1998 - 1999
Chairman, Faculty Compensation Advisory Committee, 1998 - 2004
Member, Faculty Senate Executive Committee, 1998 - 1999
Member, Faculty Senate Research Issues Committee, 1998 - 1999
Member, Steering Committee on Cancer and Minorities, 1998 - 2003
Member, Faculty Compensation Advisory Committee, 1998 - 2004
Special Reviewer, Biomedical Research Support Grant Committee, 1998 - 2003
Member, GSBS Program in Toxicology, 1998 - 2008
Chairman, Minority Faculty and Administrators Committee, 1997 - 1998
Chairman, Chemical and Biochemical Hazard Sub-Committee, 1997 - 1999
Member, Faculty Achievement Awards Parent Committee, 1997 - 1997
Member, Executive Council, Minority Faculty and Administrators Committee, 1997 - 1999
Member, Faculty Classification Committee/Promotion and Tenure Committee, 1997 - 1999
Member, Faculty Senate Salary Review Committee, 1997 - 1999
Member, Institutional Biosafety Committee, 1997 - Present
Member, Faculty Achievement Awards Parent Committee, 1996 - 1996
Member, Faculty Senate Search Policy Committee, 1994 - 1996
Member, Medical Oncology Fellowship Advisory Committee, 1994 - 1994
Member, Minority Faculty and Administrators Committee, 1994 - 1998
Member, Women and Minority Faculty and Administrator Visibility Committee, 1994 - 1995
Chairman, Faculty Senate Search Policy Committee, 1994 - 1996
Chairman, Seminar Organization Committee, Department of Clinical Investigation, 1993 - 1994
Member, Seminar Organization Committee, Department of Clinical Investigation, 1993 - 1994
Member, Institutional Faculty Senate, 1993 - 1999
Member, Faculty Senate Tenure & Promotions Committee, 1993 - 1999
Member, Admissions Committee for the GSBS Program in Toxicology, 1992 - 1994
Ad Hoc Reviewer, Institutional Animal Care and Use Committee, 1991 - 2004
Member, Institutional Leadership Committee, 1990 - 1991
Member, Laboratory Animal Resource Management Group, 1989 - 1991
Chairman, Institutional Animal Care and Use Committee, 1989 - 1991
Member, Institutional Animal Care and Use Committee, 1988 - 1991
Honors & Awards
2018 | Gerald P. Bodey Award for Excellence in Teaching, Division of Cancer Medicine |
2016 | MD Anderson Provost's Distinguished Faculty Mentor Awards |
2015 | Experimental Therapeutics Academic Program Mentoring Award |
1991 | Queen's Award for Technological Achievement: Development of Carboplatin, Government of United Kingdom |
1984 | Faculty Life Tenure, The Institute of Cancer Research |
1983 | Outstanding Research Award, 10th International Symposium on the Biological Characterization of Human Tumours: Cancer Chemotherapy and Selective Drug Development, Brighton, England |
1976 | Fogarty Fellowship Recipient, NIH |
1972 | Outstanding Undergraduate Award, Liverpool University |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Calvert, AH, Newell, DR, Gumbrell, LA, O'Reilly, S, Burnell, M, Boxall, FE, Siddik, ZH, Judson, IR, Gore, M, Wiltshaw, E. Carboplatin dosage. Journal of Clinical Oncology 41(28):4453-4454, 2023. e-Pub 2023. PMID: 37757592.
- Rodriguez-Aguayo C, Bayraktar E, Ivan C, Aslan B, Mai J, He G, Mangala LS, Jiang D, Nagaraja AS, Ozpolat B, Chavez-Reyes A, Ferrari M, Mitra R, Siddik ZH, Shen H, Yang X, Sood AK, Lopez-Berestein G. Corrigendum to "PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis" [EBioMedicine 40 (2019) 290-304]. EBioMedicine 83:104194, 2022. e-Pub 2022. PMID: 35914489.
- Subramaniam, B, Siddik, ZH, Hasima, N. Development and validation of a reversed-phase HPLC method for quantification of 1’-acetoxychavicol acetate content in a nanostructured lipid carrier formulation. Brazilian Journal of Pharmaceutical Sciences 58, 2022. e-Pub 2022.
- Mangala LS, Zuzel V, Schmandt R, Leshane ES, Halder JB, Armaiz-Pena GN, Spannuth WA, Tanaka T, Shahzad MMK, Lin YG, Nick AM, Danes CG, Lee JW, Jennings NB, Vivas-Mejia PE, Wolf JK, Coleman RL, Siddik ZH, Lopez-Berestein G, Lutsenko S, Sood AK. Editor's Note: Therapeutic Targeting of ATP7B in Ovarian Carcinoma. Clin Cancer Res 27(15):4454, 2021. e-Pub 2021. PMID: 34341059.
- Moreno-Smith M, Halder JB, Meltzer PS, Gonda TA, Mangala LS, Rupaimoole R, Lu C, Nagaraja AS, Gharpure KM, Kang Y, Rodriguez-Aguayo C, Vivas-Mejia PE, Zand B, Schmandt R, Wang H, Langley RR, Jennings NB, Ivan C, Coffin JE, Armaiz GN, Bottsford-Miller J, Kim SB, Halleck MS, Hendrix MJ, Bornman W, Bar-Eli M, Lee JS, Siddik ZH, Lopez-Berestein G, Sood AK. ATP11B mediates platinum resistance in ovarian cancer. J Clin Invest 131(7), 2021. e-Pub 2021. PMID: 33792569.
- Hong B, Chapa V, Saini U, Modgil P, Cohn DE, He G, Siddik ZH, Sood AK, Yan Y, Selvendiran K, Pei G, Zhao Z, Yoo JY, Kaur B. Oncolytic HSV therapy modulates vesicular trafficking inducing cisplatin sensitivity and anti-tumor immunity. Clin Cancer Res 27(2):542-553, 2021. e-Pub 2021. PMID: 33087329.
- He G, Xie X, Siddik ZH. Protein expression profiling identifies differential modulation of homologous recombination by platinum-based antitumor agents. Cancer Chemother Pharmacol 85(6):1129-1140, 2020. e-Pub 2020. PMID: 32468080.
- Xie X, He G, Siddik ZH. Cisplatin in Combination with MDM2 Inhibition Downregulates Rad51 Recombinase in a Bimodal Manner to Inhibit Homologous Recombination and Augment Tumor Cell Kill. Mol Pharmacol 97(4):237-249, 2020. e-Pub 2020. PMID: 32063580.
- Thiabaud G, He G, Sen S, Shelton KA, Baze WB, Segura L, Alaniz J, Munoz Macias R, Lyness G, Watts AB, Kim HM, Lee H, Cho MY, Hong KS, Finch R, Siddik ZH, Arambula JF, Sessler JL. Oxaliplatin Pt(IV) prodrugs conjugated to gadolinium-texaphyrin as potential antitumor agents. Proc Natl Acad Sci U S A 117(13):7021-7029, 2020. e-Pub 2020. PMID: 32179677.
- Thiabaud G, Harden-Bull L, Ghang YJ, Sen S, Chi X, Bachman JL, Lynch VM, Siddik ZH, Sessler JL. Platinum(IV)-Ferrocene Conjugates and Their Cyclodextrin Host-Guest Complexes. Inorg Chem 58(12):7886-7894, 2019. e-Pub 2019. PMID: 31125214.
- Rodriguez-Aguayo C, Bayraktar E, Ivan C, Aslan B, Mai J, He G, Mangala LS, Jiang D, Nagaraja AS, Ozpolat B, Chavez-Reyes A, Ferrari M, Mitra R, Siddik ZH, Shen H, Yang X, Sood AK, Lopez-Berestein G. PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis. EBioMedicine 40:290-304, 2019. e-Pub 2019. PMID: 30655206.
- Moreno-Smith M, Halder JB, Meltzer PS, Gonda TA, Mangala LS, Rupaimoole R, Lu C, Nagaraja AS, Gharpure KM, Kang Y, Rodriguez-Aguayo C, Vivas-Mejia PE, Zand B, Schmandt R, Wang H, Langley RR, Jennings NB, Ivan C, Coffin JE, Armaiz GN, Bottsford-Miller J, Kim SB, Halleck MS, Hendrix MJ, Bornman W, Bar-Eli M, Lee JS, Siddik ZH, Lopez-Berestein G, Sood AK. ATP11B mediates platinum resistance in ovarian cancer. J Clin Invest 128(7):3199, 2018. e-Pub 2018. PMID: 29809169.
- Xie X, He G, Siddik ZH. Functional Activation of Mutant p53 by Platinum Analogues in Cisplatin-Resistant Cells Is Dependent on Phosphorylation. Mol Cancer Res 15(3):328-339, 2017. e-Pub 2017. PMID: 28031409.
- Bhatt M, Ivan C, Xie X, Siddik ZH. Drug-dependent functionalization of wild-type and mutant p53 in cisplatin-resistant human ovarian tumor cells. Oncotarget 8(7):10905-10918, 2017. e-Pub 2017. PMID: 28038466.
- Altaf M, Monim-Ul-Mehboob M, Kawde AN, Corona G, Larcher R, Ogasawara M, Casagrande N, Celegato M, Borghese C, Siddik ZH, Aldinucci D, Isab AA. New bipyridine gold(III) dithiocarbamate-containing complexes exerted a potent anticancer activity against cisplatin-resistant cancer cells independent of p53 status. Oncotarget 8(1):490-505, 2017. e-Pub 2017. PMID: 27888799.
- Prasad S, Tyagi AK, Siddik ZH, Aggarwal BB. Curcumin-Free Turmeric Exhibits Activity against Human HCT-116 Colon Tumor Xenograft: Comparison with Curcumin and Whole Turmeric. Front Pharmacol 8:871, 2017. e-Pub 2017. PMID: 29311914.
- Thiabaud G, McCall R, He G, Arambula JF, Siddik ZH, Sessler JL. Activation of Platinum(IV) Prodrugs By Motexafin Gadolinium as a Redox Mediator. Angew Chem Int Ed Engl 55(41):12626-31, 2016. e-Pub 2016. PMID: 27377046.
- Xie X, Lozano G, Siddik ZH. Heterozygous p53V172F mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53. Oncogene 35(36):4798-4806, 2016. e-Pub 2016. PMID: 26876197.
- Tsimberidou AM, Said R, Culotta K, Wistuba I, Jelinek J, Fu S, Falchook G, Naing A, Piha-Paul S, Zinner R, Siddik ZH, He G, Hess K, Stewart DJ, Kurzrock R, Issa JP. Phase I study of azacitidine and oxaliplatin in patients with advanced cancers that have relapsed or are refractory to any platinum therapy. Clin Epigenetics 7(1):29, 2015. e-Pub 2015. PMID: 25806091.
- Thiabaud G, Arambula JF, Siddik ZH, Sessler JL. Photoinduced reduction of Pt(IV) within an anti-proliferative Pt(IV)-texaphyrin conjugate. Chemistry 20(29):8942-7, 2014. e-Pub 2014. PMID: 24961491.
- Kim ES, Tang X, Peterson DR, Kilari D, Chow CW, Fujimoto J, Kalhor N, Swisher SG, Stewart DJ, Wistuba II, Siddik ZH. Copper transporter CTR1 expression and tissue platinum concentration in non-small cell lung cancer. Lung Cancer 85(1):88-93, 2014. e-Pub 2014. PMID: 24792335.
- Preihs C, Arambula JF, Magda D, Jeong H, Yoo D, Cheon J, Siddik ZH, Sessler JL. Recent Developments in Texaphyrin Chemistry and Drug Discovery. Inorg Chem 52(21):12184-12192, 2013. e-Pub 2013. PMID: 23557113.
- He G, Kuang J, Koomen J, Kobayashi R, Khokhar AR, Siddik ZH. Recruitment of trimeric proliferating cell nuclear antigen by G1-phase cyclin-dependent kinases following DNA damage with platinum-based antitumor agents. Br J Cancer 109(9):2378-88, 2013. e-Pub 2013. PMID: 24104967.
- Moreno-Smith M, Lee SJ, Lu C, Nagaraja AS, He G, Rupaimoole R, Han HD, Jennings NB, Roh JW, Nishimura M, Kang Y, Allen JK, Armaiz GN, Matsuo K, Shahzad MM, Bottsford-Miller J, Langley RR, Cole SW, Lutgendorf SK, Siddik ZH, Sood AK. Biologic effects of dopamine on tumor vasculature in ovarian carcinoma. Neoplasia 15(5):502-10, 2013. e-Pub 2013. PMID: 23633922.
- Moreno-Smith M, Halder JB, Meltzer PS, Gonda TA, Mangala LS, Rupaimoole R, Lu C, Nagaraja AS, Gharpure KM, Kang Y, Rodriguez-Aguayo C, Vivas-Mejia PE, Zand B, Schmandt R, Wang H, Langley RR, Jennings NB, Ivan C, Coffin JE, Armaiz GN, Bottsford-Miller J, Kim SB, Halleck MS, Hendrix MJ, Bornman W, Bar-Eli M, Lee JS, Siddik ZH, Lopez-Berestein G, Sood AK. ATP11B mediates platinum resistance in ovarian cancer. J Clin Invest 123(5):2119-30, 2013. e-Pub 2013. PMID: 23585472.
- Kim ES, Lee JJ, He G, Chow CW, Fujimoto J, Kalhor N, Swisher SG, Wistuba II, Stewart DJ, Siddik ZH. Tissue platinum concentration and tumor response in non-small-cell lung cancer. J Clin Oncol 30(27):3345-52, 2012. e-Pub 2012. PMID: 22891266.
- Arambula JF, Sessler JL, Siddik ZH. A texaphyrin-oxaliplatin conjugate that overcomes both pharmacologic and molecular mechanisms of cisplatin resistance in cancer cells. Medchemcomm 3(10):1275-1281, 2012. e-Pub 2012. PMID: 23936624.
- Le XF, Mao W, He G, Claret FX, Xia W, Ahmed AA, Hung MC, Siddik ZH, Bast RC. The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells. J Natl Cancer Inst 103(18):1403-22, 2011. e-Pub 2011. PMID: 21813412.
- He G, Kuang J, Khokhar AR, Siddik ZH. The impact of S- and G2-checkpoint response on the fidelity of G1-arrest by cisplatin and its comparison to a non cross-resistant platinum (IV) analog. Gynecol Oncol 122(2):402-409, 2011. e-Pub 2011. PMID: 21592546.
- Arambula JF, Sessler JL, Siddik ZH. Overcoming biochemical pharmacologic mechanisms of platinum resistance with a texaphyrin-platinum conjugate. Bioorg Med Chem Lett 21(6):1701-5, 2011. e-Pub 2011. PMID: 21345675.
- Preihs C, Arambula JF, Lynch VM, Siddik ZH, Sessler JL. Bismuth- and lead-texaphyrin complexes: towards potential a-core emitters for radiotherapy. Chem Commun (Camb) 46(42):7900-2, 2010. e-Pub 2010. PMID: 20922235.
- Kurokawa T, He G, Siddik ZH. Protein kinase inhibitors emodin and dichloro-ribofuranosylbenzimidazole modulate the cellular accumulation and cytotoxicity of cisplatin in a schedule-dependent manner. Cancer Chemother Pharmacol 65(3):427-36, 2010. e-Pub 2010. PMID: 19529937.
- Rowe RW, Strebel FR, Proett JM, Deng W, Chan D, He G, Siddik Z, Bull JM. Fever-range whole body thermotherapy combined with oxaliplatin: A curative regimen in a pre-clinical breast cancer model. Int J Hyperthermia 26(6):565-576, 2010. e-Pub 2010. PMID: 20707651.
- Arambula JF, Sessler JL, Fountain ME, Wei WH, Magda D, Siddik ZH. Gadolinium Texaphyrin (Gd-Tex)-Malonato-Platinum Conjugates: Synthesis and Comparison with Carboplatin in Normal and Pt-Resistant Cell Lines. Dalton Trans(48):10834-40, 2009. e-Pub 2009. PMID: 20023913.
- Mangala LS, Zuzel V, Schmandt R, Leshane ES, Halder JB, Armaiz-Pena GN, Spannuth WA, Tanaka T, Shahzad MM, Lin YG, Nick AM, Danes CG, Lee JW, Jennings NB, Vivas-Mejia PE, Wolf JK, Coleman RL, Siddik ZH, Lopez-Berestein G, Lutsenko S, Sood AK. Therapeutic Targeting of ATP7B in Ovarian Carcinoma. Clin Cancer Res 15(11):3770-80, 2009. e-Pub 2009. PMID: 19470734.
- Chen HH, Song IS, Hossain A, Choi MK, Yamane Y, Liang ZD, Lu J, Wu LY, Siddik ZH, Klomp LW, Savaraj N, Kuo MT. Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1. Mol Pharmacol 74(3):697-704, 2008. e-Pub 2008. PMID: 18523133.
- Lu Y, Li X, Liang K, Luwor R, Siddik ZH, Mills GB, Mendelsohn J, Fan Z. Epidermal Growth Factor (EGF) Receptor Ubiquitination as a Mechanism of Acquired Resistance to the Anti-EGF Receptor Monoclonal Antibody Cetuximab. Cancer Res 67(17):8240-7, 2007. e-Pub 2007. PMID: 17804738.
- He G, Kuang J, Huang Z, Koomen J, Kobayashi R, Khokhar AR, Siddik ZH. Upregulation of p27 and its inhibition of CDK2/cyclin E activity following DNA damage by a novel platinum agent are dependent on the expression of p21. Br J Cancer 95(11):1514-24, 2006. e-Pub 2006. PMID: 17088910.
- He G, Siddik ZH, Huang Z, Wang R, Koomen J, Kobayashi R, Khokhar AR, Kuang J. Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities. . Oncogene 24(18):2929-2943, 2005. e-Pub 2005. PMID: 15735718.
- Ali MS, Khan SR, Ojima H, Guzman IY, Whitmire KH, Siddik ZH, Khokhar AR. Model platinum nucleobase and nucleoside complexes and antitumor activity: X-ray crystal structure of [Pt(IV)(trans-1R,2R-diaminocyclohexane)trans-(acetate)2(9-ethylguanine)Cl]NO3.H2O. . J Inorg Biochem 99(3):795-804, 2005. e-Pub 2005. PMID: 15708801.
- Mujoo K, Watanabe M, Khokhar AR, Siddik ZH. Increased sensitivity of a metastatic model of prostate cancer to a novel tetravalent platinum analog. Prostate 62(1):91-100, 2005. e-Pub 2005. PMID: 15389812.
- Song IS, Savaraj N, Siddik ZH, Liu P, Wei Y, Wu CJ, Kuo MT. Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells. Mol Cancer Ther 3(12):1543-9, 2004. e-Pub 2004. PMID: 15634647.
- Mujoo K, Watanabe M, Nakamura J, Khokhar AR, Siddik ZH. Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents. J Cancer Res Clin Oncol 129(12):709-18, 2003. e-Pub 2003. PMID: 14513366.
- Verschraegen CF, Kumagai S, Davidson R, Feig B, Mansfield P, Lee SJ, Maclean DS, Hu W, Khokhar AR, Siddik ZH. Phase I clinical and pharmacological study of intraperitoneal cis-bis-neodecanoato( trans- R, R-1, 2-diaminocyclohexane)-platinum II entrapped in multilamellar liposome vesicles. J Cancer Res Clin Oncol 129(10):549-55, 2003. e-Pub 2003. PMID: 14513369.
- Mansouri A, Ridgway LD, Korapati AL, Zhang Q, Tian L, Wang Y, Siddik ZH, Mills GB, Claret FX. Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. J Biol Chem 278(21):19245-56, 2003. e-Pub 2003. PMID: 12637505.
- Mukhopadhyay U, Thurston J, Whitmire KH, Siddik ZH, Khokhar AR. Preparation, characterization, and antitumor activity of new cisplatin analogues with 1-methyl-4-(methylamino)piperidine: crystal structure of [PtII(1-methyl-4-(methylamino) piperidine)(oxalate)]. J Inorg Biochem 94(1-2):179-85, 2003. e-Pub 2003. PMID: 12620689.
- Kuang J, He G, Huang Z, Khokhar AR, Siddik ZH. Bimodal effects of 1R,2R-diaminocyclohexane(trans-diacetato)(dichloro)platinum(IV) on cell cycle checkpoints. Clin Cancer Res 7(11):3629-39, 2001. e-Pub 2001. PMID: 11705886.
- Ali Khan SR, Huang S, Shamsuddin S, Inutsuka S, Whitmire KH, Siddik ZH, Khokhar AR. Synthesis, characterization and cytotoxicity of new platinum(IV) axial carboxylate complexes: crystal structure of potential antitumor agent [PtIV(trans-1R,2R-diaminocyclohexane)trans(acetate)2Cl2]. Bioorg Med Chem 8(3):515-21, 2000. e-Pub 2000. PMID: 10732967.
- Donato NJ, Perez M, Kang H, Siddik ZH, Ling YH, Perez-Soler R. EGF receptor and p21WAF1 expression are reciprocally altered as ME-180 cervical carcinoma cells progress from high to low cisplatin sensitivity. Clin Cancer Res 6(1):193-202, 2000. e-Pub 2000. PMID: 10656450.
- Furui T, LaPushin R, Mao M, Khan H, Watt SR, Watt MA, Lu Y, Fang X, Tsutsui S, Siddik ZH, Bast RC, Mills GB. Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner. Clin Cancer Res 5(12):4308-18, 1999. e-Pub 1999. PMID: 10632375.
- Ali MS, Whitmire KH, Toyomasu T, Siddik ZH, Khokhar AR. Preparation, characterization, and antitumor activity of new cisplatin analogs with homopiperazines: crystal structure of [PtII(1-methylhomopiperazine)(methylmalonato)].2H2O. J Inorg Biochem 77(3-4):231-8, 1999. e-Pub 1999. PMID: 10643661.
- Hagopian GS, Mills GB, Khokhar AR, Bast RC, Siddik ZH. Expression of p53 in cisplatin-resistant ovarian cancer cell lines: modulation with the novel platinum analogue (1R, 2R-diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV). Clin Cancer Res 5(3):655-63, 1999. e-Pub 1999. PMID: 10100719.
- Yoshida M, Khokhar AR, Siddik ZH. Cytotoxicity and tolerance to DNA adducts of alicyclic mixed amine platinum(II) homologs in tumor models sensitive and resistant to cisplatin or tetraplatin. Oncol Rep 5(5):1281-7, 1998. e-Pub 1998. PMID: 9683851.
- Shamsuddin S, Santillan CC, Stark JL, Whitmire KH, Siddik ZH, Khokhar AR. Synthesis, characterization, and antitumor activity of new platinum(IV) trans-carboxylate complexes: crystal structure of [Pt(cis-1,4-DACH)trans-(acetate)2Cl2]. J Inorg Biochem 71(1-2):29-35, 1998. e-Pub 1998. PMID: 9755489.
- Siddik ZH, Mims B, Lozano G, Thai G. Independent pathways of p53 induction by cisplatin and X-rays in a cisplatin-resistant ovarian tumor cell line. Cancer Res 58(4):698-703, 1998. e-Pub 1998. PMID: 9485023.
- Kudelka AP, Siddik ZH, Tresukosol D, Edwards CL, Freedman RS, Madden TL, Rastogi R, Hord M, Kim EE, Tornos C, Mante R, Kavanagh JJ. A phase II and pharmacokinetic study of enloplatin in patients with platinum refractory advanced ovarian carcinoma. Anticancer Drugs 8(7):649-56, 1997. e-Pub 1997. PMID: 9311439.
- Perez-Soler R, Shin DM, Siddik ZH, Murphy WK, Huber M, Lee SJ, Khokhar AR, Hong WK. Phase I clinical and pharmacological study of liposome-entrapped NDDP administered intrapleurally in patients with malignant pleural effusions. Clin Cancer Res 3(3):373-9, 1997. e-Pub 1997. PMID: 9815694.
- Khokhar AR, al-Baker S, Shamsuddin S, Siddik ZH. Chemical and biological studies on a series of novel (trans-(1R,2R)-, trans-(1S,2S)-, and cis-1,2-diaminocyclohexane)platinum(IV) carboxylate complexes. J Med Chem 40(1):112-6, 1997. e-Pub 1997. PMID: 9016335.
- Shamsuddin S, Takahashi I, Siddik ZH, Khokhar AR. Synthesis, characterization, and antitumor activity of a series of novel cisplatin analogs with cis-1,4-diaminocyclohexane as nonleaving amine group. J Inorg Biochem 61(4):291-301, 1996. e-Pub 1996. PMID: 8867456.
- Kantarjian HM, Beran M, O'Brien S, Robertson L, Siddik Z, Yoshida M, Yang LY, Rios MB, Keating MJ, Meyer M, et al. Evaluation of CI-973, a platinum analogue, in refractory or relapsed acute leukemia. Leukemia 10(3):396-401, 1996. e-Pub 1996. PMID: 8642853.
- Klostergaard J, Leroux ME, Hsu HA, Hsi BP, Siddik ZH, Danhauser LL, Tomasovic SP. Multi-chemothermoimmunotherapy for human colon adenocarcinoma in vitro. Cancer Chemother Pharmacol 37(3):235-41, 1996. e-Pub 1996. PMID: 8529283.
- Shamsuddin S, Al-Baker S, Siddik ZH, Khokhar AR. Synthesis and antitumor activity of new trans-1R,2R-diaminocyclohexaneplatinum(II) complexes containing disubstituted sulfide as a leaving group. . Inorg Chim Acta 241:101-104, 1996. e-Pub 1996.
- Davidson BS, Izzo F, Cromeens DM, Stephens LC, Siddik ZH, Curley SA. Collagen matrix cisplatin prevents local tumor growth after margin-positive resection. J Surg Res 58(6):618-24, 1995. e-Pub 1995. PMID: 7791337.
- Curley SA, Fuhrman GM, Siddik ZH, Davidson BS, Cleary KR, Cromeens DM. Direct intratumoral injection of a novel collagen matrix gel and cisplatin effectively controls experimental liver tumors. Cancer Res Ther Control 4:247-254, 1995. e-Pub 1995.
- Wondergem J, Strebel FR, Stephens LC, Siddik ZH, Bull JM. Chronic effect of whole-body hyperthermia combined simultaneously with cis-diamminedichloroplatinum (II) on normal tissue in rat. Int J Hyperthermia 11(1):37-47, 1995. e-Pub 1995. PMID: 7714369.
- Siddik ZH, Thai G, Yoshida M, Zhang YP, Khokhar AR. Tetravalent platinum complexes with ammine/amine carrier ligand configuration: circumvention of platinum resistance in vivo. Anticancer Drug Des 9(6):495-509, 1994. e-Pub 1994. PMID: 7880375.
- Yoshida M, Khokhar AR, Siddik ZH. Circumvention of platinum resistance: structure-activity relationship for homologous series of ammine/amine platinum(II) complexes in L1210 cell lines. Anticancer Drug Des 9(5):425-34, 1994. e-Pub 1994. PMID: 7945726.
- Yoshida M, Khokhar AR, Siddik ZH. Axial ligands and alicyclic ring size modulate the activity and biochemical pharmacology of ammine/cycloalkylamine-platinum(IV) complexes in tumor cells resistant to cis-diamminedichloroplatinum(II) or trans-1R,2R-1S,2S-diaminocyclohexanetetrachloroplatinum(IV). Cancer Res 54(17):4691-7, 1994. e-Pub 1994. PMID: 8062266.
- Yoshida M, Khokhar AR, Kido Y, Ali-Osman F, Siddik ZH. Correlation of total and interstrand DNA adducts in tumor and kidney with antitumor efficacies and differential nephrotoxicities of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin. Biochem Pharmacol 48(4):793-9, 1994. e-Pub 1994. PMID: 8080453.
- Yoshida M, Khokhar AR, Siddik ZH. Biochemical pharmacology of homologous alicyclic mixed amine platinum(II) complexes in sensitive and resistant tumor cell lines. Cancer Res 54(13):3468-73, 1994. e-Pub 1994. PMID: 8012968.
- Siddik ZH, al-Baker S, Thai G, Khokhar AR. Modulatory effect of axial and equatorial ligands on antitumor activities of trans-1R,2R-diaminocyclohexane platinum(IV) complexes. Anticancer Drug Des 9(2):139-51, 1994. e-Pub 1994. PMID: 8166929.
- Khokhar AR, al-Baker S, Siddik ZH. Synthesis and antitumor activity of 1,2-diaminocyclohexane platinum(IV) complexes. J Inorg Biochem 54(1):39-47, 1994. e-Pub 1994. PMID: 8151310.
- Kido Y, Khokhar AR, Siddik ZH. Glutathione-mediated modulation of tetraplatin activity against sensitive and resistant tumor cells. Biochem Pharmacol 47(9):1635-42, 1994. e-Pub 1994. PMID: 8185678.
- Kido Y, Khokhar AR, Yoshida M, Thai GW, Siddik ZH. Pharmacokinetics of tetraplatin administered intraperitoneally with reduced glutathione in mice. Drug Metab Dispos 22(2):312-7, 1994. e-Pub 1994. PMID: 8013287.
- Khokhar AR, Xu Q, Siddik ZH. Synthesis, characterization, and antitumor activity of amine platinum(II) and (IV) tellurate complexes. J Inorg Biochem 53(4):295-301, 1994. e-Pub 1994. PMID: 8169608.
- Ohno S, Siddik ZH, Kido Y, Zwelling LA, Bull JM. Thermal enhancement of drug uptake and DNA adducts as a possible mechanism for the effect of sequencing hyperthermia on cisplatin-induced cytotoxicity in L1210 cells. Cancer Chemother Pharmacol 34(4):302-6, 1994. e-Pub 1994. PMID: 8033297.
- Al-Baker S, Siddik ZH, Khokhar AR. Synthesis and characterization of new antitumor trans-R,R-, trans-S,S- and cis-1,2-diaminocyclohexane platinum(IV) complexes. . J Coord Chem 31:109-116, 1994. e-Pub 1994.
- Yoshida M, Khokhar AR, Zhang YP, Thai G, Siddik ZH. Kinetics of tissue disposition of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin in mice bearing FSaIIC tumors. Cancer Chemother Pharmacol 35(1):38-44, 1994. e-Pub 1994. PMID: 7987975.
- Siddik ZH, Thai G, Yoshida M, Zhang YP, Khokhar AR. Ammine/amine platinum (II) complexes effective in vivo against murine tumors sensitive or resistant to cisplatin and tetraplatin. J Cancer Res Clin Oncol 120(10):571-7, 1994. e-Pub 1994. PMID: 7929527.
- Siddik ZH, al-Baker S, Thai G, Khokhar AR. Antitumor activity of isomeric 1,2-diaminocyclohexane platinum(IV) complexes. J Cancer Res Clin Oncol 120(7):409-14, 1994. e-Pub 1994. PMID: 8188734.
- Kido Y, Khokhar AR, al-Baker S, Siddik ZH. Modulation of cytotoxicity and cellular pharmacology of 1,2-diaminocyclohexane platinum (IV) complexes mediated by axial and equatorial ligands. Cancer Res 53(19):4567-72, 1993. e-Pub 1993. PMID: 8402629.
- Ohno S, Strebel FR, Stephens LC, Siddik ZH, Baba H, Makino M, Khokhar AR, Bull JM. Haematological toxicity of carboplatin and cisplatin combined with whole body hyperthermia in rats. Br J Cancer 68(3):469-74, 1993. e-Pub 1993. PMID: 8353037.
- Khokhar AR, Deng Y, al-Baker S, Yoshida M, Siddik ZH. Synthesis and antitumor activity of ammine/amine platinum(II) and (IV) complexes. J Inorg Biochem 51(3):677-87, 1993. e-Pub 1993. PMID: 8409984.
- Khokhar AR, Deng Y, Kido Y, Siddik ZH. Preparation, characterization, and antitumor activity of new ethylenediamine platinum(IV) complexes containing mixed carboxylate ligands. J Inorg Biochem 50(2):79-87, 1993. e-Pub 1993. PMID: 8487040.
- Kido Y, Khokhar AR, Siddik ZH. Differential cytotoxicity, uptake and DNA binding of tetraplatin and analogous isomers in sensitive and resistant cancer cell lines. Anticancer Drugs 4(2):251-8, 1993. e-Pub 1993. PMID: 8490203.
- Yang LY, Trujillo JM, Siciliano MJ, Kido Y, Siddik ZH, Su YZ. Distinct P-glycoprotein expression in two subclones simultaneously selected from a human colon carcinoma cell line by cis-diamminedichloroplatinum (II). Int J Cancer 53(3):478-85, 1993. e-Pub 1993. PMID: 8094074.
- Curley SA, Stone DL, Fuhrman GM, Hohn DC, Siddik ZH, Newman RA. Increased doxorubicin levels in hepatic tumors with reduced systemic drug exposure achieved with complete hepatic venous isolation and extracorporeal chemofiltration. Cancer Chemother Pharmacol 33(3):251-7, 1993. e-Pub 1993. PMID: 8269607.
- Wondergem J, Siddik ZH, Strebel FR, Bull JM. Effect of whole body hyperthermia on cis-diamminedichloroplatinum (II)-induced antitumour activity and tissue Pt-distribution: do anaesthetics influence the therapeutic ratio?. Eur J Cancer 29A(4):549-54, 1993. e-Pub 1993. PMID: 8435209.
- Klostergaard J, Leroux E, Siddik ZH, Khodadadian M, Tomasovic SP. Enhanced sensitivity of human colon tumor cell lines in vitro in response to thermochemoimmunotherapy. Cancer Res 52(19):5271-7, 1992. e-Pub 1992. PMID: 1394131.
- Kido Y, Khokhar AR, Siddik ZH. Pharmacokinetics of intravenously injected [3H]tetrachloro(D,L-trans)1,2-diaminocyclohexane platinum (IV) (tetraplatin) in mice. Drug Metab Dispos 20(5):673-8, 1992. e-Pub 1992. PMID: 1358571.
- Ohno S, Strebel FR, Stephens LC, Siddik ZH, Makino M, Klostergaard J, Tomasovic SP, Khokhar AR, Bull JM. Increased therapeutic efficacy induced by tumor necrosis factor alpha combined with platinum complexes and whole-body hyperthermia in rats. Cancer Res 52(15):4096-101, 1992. e-Pub 1992. PMID: 1638521.
- Khokhar AR, Xu Q, Newman RA, Kido Y, Siddik ZH. Synthesis, characterization, and antitumor activity of new chloroethylamine platinum complexes. J Inorg Biochem 45(3):211-9, 1992. e-Pub 1992. PMID: 1634893.
- Vadiei K, Siddik ZH, Khokhar AR, al-Baker S, Sampedro F, Perez-Soler R. Pharmacokinetics of liposome-entrapped cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum(II) and cisplatin given i.v. and i.p. in the rat. Cancer Chemother Pharmacol 30(5):365-9, 1992. e-Pub 1992. PMID: 1505075.
- Khokhar AR, Xu QY, Newman RA, Siddik ZH. Preparation, characterization, and antitumor activity of water-soluble aminoalkanol platinum(II) complexes. J Inorg Biochem 43(1):57-63, 1991. e-Pub 1991. PMID: 1940901.
- Baba H, Stephens LC, Strebel FR, Siddik ZH, Newman RA, Ohno S, Bull JM. Protective effect of ICRF-187 against normal tissue injury induced by adriamycin in combination with whole body hyperthermia. Cancer Res 51(13):3568-77, 1991. e-Pub 1991. PMID: 1905199.
- Wondergem J, Stephens LC, Strebel FR, Baba H, Ohno S, Siddik ZH, Newman RA, Bull JM. Effect of adriamycin combined with whole body hyperthermia on tumor and normal tissues. Cancer Res 51(13):3559-67, 1991. e-Pub 1991. PMID: 2054792.
- Ohno S, Siddik ZH, Baba H, Stephens LC, Strebel FR, Wondergem J, Khokhar AR, Bull JM. Effect of carboplatin combined with whole body hyperthermia on normal tissue and tumor in rats. Cancer Res 51(11):2994-3000, 1991. e-Pub 1991. PMID: 2032236.
- Garteiz D, Siddik ZH, Newman RA. In vitro and in vivo murine metabolism of spirogermanium. Drug Metab Dispos 19(1):44-7, 1991. e-Pub 1991. PMID: 1673420.
- Khokhar AR, Xu QY, Siddik ZH. Synthesis, characterization, and antitumor activity of 1,2-bis(diphenylphosphino) ethane platinum(II) and palladium(II) complexes. J Inorg Biochem 39(2):117-23, 1990. e-Pub 1990. PMID: 2380705.
- Newman RA, Siddik ZH, Travis EL, Followill D, Ayele W, Burditt T, Krakoff IH. Assessment of pulmonary and hematologic toxicities of liblomycin, a novel bleomycin analog. Invest New Drugs 8(1):33-41, 1990. e-Pub 1990. PMID: 1693138.
- Ho BT, Tansey LW, Engineer MS, Newman RA, Siddik ZH, Field WS, Krakoff IH. Beta-adrenoceptor binding studies with LY195448 and metabolites. Res Commun Chem Pathol Pharmacol 67(1):143-6, 1990. e-Pub 1990. PMID: 2158135.
- Graham RA, Siddik ZH, Hohn DC. Extracorporeal hemofiltration: a model for decreasing systemic drug exposure with intra-arterial chemotherapy. Cancer Chemother Pharmacol 26(3):210-4, 1990. e-Pub 1990. PMID: 2357769.
- Baba H, Siddik ZH, Strebel FR, Jenkins GN, Bull JM. Increased therapeutic gain of combined cis-diamminedichloroplatinum (II) and whole body hyperthermia therapy by optimal heat/drug scheduling. Cancer Res 49(24 Pt 1):7041-4, 1989. e-Pub 1989. PMID: 2582445.
- Calvert AH, Newell DR, Gumbrell LA, O'Reilly S, Burnell M, Boxall FE, Siddik ZH, Judson IR, Gore ME, Wiltshaw E. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol 7(11):1748-56, 1989. e-Pub 1989. PMID: 2681557.
- Wondergem J, Bulger RE, Siddik ZH, Leygraaf JW, Strebel FR, Alonso M, Travis EL, Bull JM. A comparison of thermal enhancement of cis-diamminedichloroplatinum (II) induced renal and intestinal toxicities by whole body hyperthermia in the rat. Int J Radiat Oncol Biol Phys 16(6):1551-6, 1989. e-Pub 1989. PMID: 2722594.
- Newman RA, Osborn S, Siddik ZH. Determination of tellurium in biological fluids by means of electrothermal vaporization-inductively coupled plasma-mass spectrometry (ETV-ICP-MS). Clin Chim Acta 179(2):191-6, 1989. e-Pub 1989. PMID: 2920448.
- Wondergem J, Strebel FR, Siddik ZH, Newman RA, Bull JM. The effects of anaesthetics on cisplatinum-induced toxicity at normal temperatures and during whole-body hyperthermia: the influence of NaCl concentration of the vehicle. Int J Hyperthermia 4(6):643-54, 1988. e-Pub 1988. PMID: 3171259.
- Siddik ZH, Newman RA. Use of platinum as a modifier in the sensitive detection of tellurium in biological samples. Anal Biochem 172(1):190-6, 1988. e-Pub 1988. PMID: 3189763.
- Bull JM, Strebel FR, Sunderland BA, Bulger RE, Edwards M, Siddik ZH, Newman RA. o-(beta-Hydroxyethyl)-rutoside-mediated protection of renal injury associated with cis-diamminedichloroplatinum(II)/hyperthermia treatment. Cancer Res 48(8):2239-44, 1988. e-Pub 1988. PMID: 3349489.
- Lautersztain J, Perez-Soler R, Turpin J, Khokhar AR, Siddik ZH, Schmidt K, Lopez-Berestein G. Cellular pharmacology of liposomal cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum (II) in mouse resident peritoneal macrophages, Kupffer cells, and hepatocytes. Cancer Res 48(5):1300-6, 1988. e-Pub 1988. PMID: 3342409.
- Khokhar AR, Wright K, Siddik ZH, Perez-Soler R. Organ distribution and tumor uptake of liposome entrapped cis-bis-neodecanoato trans-R, R-1,2 diaminocyclohexane platinum (II) administered intravenously and into the proper hepatic artery. Cancer Chemother Pharmacol 22(3):223-7, 1988. e-Pub 1988. PMID: 3409456.
- Dible SE, Siddik ZH, Harrap KR. The comparative tissues distribution of platinum and 14C in mice receiving 14C-labelled carboplatin. Cancer Chemother Pharmacol 22(1):11-6, 1988. e-Pub 1988. PMID: 3293838.
- Siddik ZH, Jones M, Boxall FE, Harrap KR. Comparative distribution and excretion of carboplatin and cisplatin in mice. Cancer Chemother Pharmacol 21(1):19-24, 1988. e-Pub 1988. PMID: 3277732.
- Newell DR, Siddik ZH, Gumbrell LA, Boxall FE, Gore ME, Smith IE, Calvert AH. Plasma free platinum pharmacokinetics in patients treated with high dose carboplatin. Eur J Cancer Clin Oncol 23(9):1399-405, 1987. e-Pub 1987. PMID: 3315699.
- Dible SE, Siddik ZH, Boxall FE, Harrap KR. The effect of diethyldithiocarbamate on the haematological toxicity and antitumour activity of carboplatin. Eur J Cancer Clin Oncol 23(6):813-8, 1987. e-Pub 1987. PMID: 2820745.
- Siddik ZH, Newell DR, Boxall FE, Harrap KR. The comparative pharmacokinetics of carboplatin and cisplatin in mice and rats. Biochem Pharmacol 36(12):1925-32, 1987. e-Pub 1987. PMID: 3297068.
- Siddik ZH, Boxall FE, Harrap KR. Flameless atomic absorption spectrophotometric determination of platinum in tissues solubilized in hyamine hydroxide. Anal Biochem 163(1):21-6, 1987. e-Pub 1987. PMID: 3039867.
- Siddik ZH, Boxall FE, Harrap KR. Haematological toxicity of carboplatin in rats. Br J Cancer 55(4):375-9, 1987. e-Pub 1987. PMID: 3555590.
- Gore ME, Hills CA, Siddik ZH, Sloane JP, Winkley AR, Smith IE, Millar JL. Priming reduces the bone marrow toxicity of carboplatin. Eur J Cancer Clin Oncol 23(1):75-80, 1987. e-Pub 1987. PMID: 3297714.
- Siddik ZH. Minimising the organ toxic effects of chemotherapy. Eur J Cancer Clin Oncol 22(8):905-7, 1986. e-Pub 1986. PMID: 3770047.
- Calvert AH, Alison DL, Harland SJ, Robinson BA, Jackman AL, Jones TR, Newell DR, Siddik ZH, Wiltshaw E, McElwain TJ, et al. A phase I evaluation of the quinazoline antifolate thymidylate synthase inhibitor, N10-propargyl-5,8-dideazafolic acid, CB3717. J Clin Oncol 4(8):1245-52, 1986. e-Pub 1986. PMID: 3734849.
- Radacic M, Siddik ZH, Newell DR. Para-amino-hippurate (PAH) test as an indicator of nephrotoxicity. . Yugoslav Physiol Pharmacol Acta 21:277-278, 1986. e-Pub 1986.
- Calvert AH, Harland SJ, Newell DR, Siddik ZH, Harrap KR. Phase I studies with carboplatin at the Royal Marsden Hospital. Cancer Treat Rev 12 Suppl A:51-7, 1985. e-Pub 1985. PMID: 3910222.
- Millar BC, Siddik ZH, Millar JL, Jinks S. Mesna does not reduce cisplatin induced nephrotoxicity in the rat. Cancer Chemother Pharmacol 15(3):307-9, 1985. e-Pub 1985. PMID: 3931929.
- Harland SJ, Newell DR, Siddik ZH, Chadwick R, Calvert AH, Harrap KR. Pharmacokinetics of cis-diammine-1,1-cyclobutane dicarboxylate platinum(II) in patients with normal and impaired renal function. Cancer Res 44(4):1693-7, 1984. e-Pub 1984. PMID: 6367971.
- Trush MA, Mimnaugh EG, Siddik ZH, Gram TE. Bleomycin-metal interaction: ferrous iron-initiated chemiluminescence. Biochem Biophys Res Commun 112(2):378-83, 1983. e-Pub 1983. PMID: 6189484.
- Litterst CL, Tong S, Hirokata Y, Siddik ZH. Stimulation of microsomal drug oxidation in liver and kidney of rats treated with the oncolytic agent cis-dichlorodiammineplatinum-II. Pharmacology 26(1):46-53, 1983. e-Pub 1983. PMID: 6681909.
- Hirokata Y, Tong S, Siddik ZH, Trush MA, Mimnaugh EG, Gram TE. Sex-dependent differences in the effects of portacaval anastomosis on hepatic monooxygenases in rats. Biochem Pharmacol 31(4):499-502, 1982. e-Pub 1982. PMID: 6802138.
- Litterst CL, Tong S, Hirokata Y, Siddik ZH. Alterations in hepatic and renal levels of glutathione and activities of glutathione S-transferase from rats treated with cis-dichlorodiammineplatinum-II. Cancer Chemother Pharmacol 8(1):67-71, 1982. e-Pub 1982. PMID: 7201357.
- Calvert AH, Harland SJ, Newell DR, Siddik ZH, Jones AC, McElwain TJ, Raju S, Wiltshaw E, Smith IE, Baker JM, Peckham MJ, Harrap KR. Early clinical studies with cis-diammine-1,1-cyclobutane dicarboxylate platinum II. Cancer Chemother Pharmacol 9(3):140-7, 1982. e-Pub 1982. PMID: 6761010.
- Drew R, Siddik Z. Drug uptake by lung slices from paraquat-pretreated rats. Experientia 37(10):1093-5, 1981. e-Pub 1981. PMID: 7308402.
- Drew R, Siddik ZH, Mimnaugh EG, Gram TE. Species and dose differences in the accumulation of imipramine by mammalian lungs. Drug Metab Dispos 9(4):322-6, 1981. e-Pub 1981. PMID: 6114830.
- Siddik ZH, Drew R, Gram TE. Metabolism and biliary excretion of sulfobromophthalein in vitamin A deficiency. Biochem Pharmacol 29(19):2583-8, 1980. e-Pub 1980. PMID: 7426064.
- Siddik ZH, Mimnaugh EG, Trush MA, Gram TE. The effect of vitamin A deficiency on hepatic, renal and pulmonary glutathione S-transferase activities in the rat. Biochem J 188(3):889-93, 1980. e-Pub 1980. PMID: 7470042.
- Sikic BI, Siddik ZH, Gram TE. Relative pulmonary toxicity and antitumor effects of two new bleomycin analogs, pepleomycin and tallysomycin A. Cancer Treat Rep 64(4-5):659-67, 1980. e-Pub 1980. PMID: 6159079.
- Siddik ZH, Trush MA, Gram TE. Pulmonary accumulation of drugs in vitamin A deficiency. Lung 157(4):209-17, 1980. e-Pub 1980. PMID: 7401686.
- Drew R, Siddik ZH. Effect of a specific 5HT uptake inhibitor (citalopram) on drug accumulation by rat lung slices. Pharmacology 20(1):27-31, 1980. e-Pub 1980. PMID: 6929555.
- Siddik ZH, Drew R, Litterst CL, Mimnaugh EG, Sikic BI, Gram TE. Hepatic cytochrome P-450-dependent metabolism and enzymatic conjugation of foreign compounds in vitamin A-deficient rats. Pharmacology 21(6):383-90, 1980. e-Pub 1980. PMID: 7220590.
- Siddik ZH, Barnes RD, Dring LG, Smith RL, Williams RT. The fate of lysergic acid DI[14C]ethylamide ([14C]LSD) in the rat, guinea pig and rhesus monkey and of [14C]iso-LSD in rat. Biochem Pharmacol 28(20):3093-101, 1979. e-Pub 1979. PMID: 117811.
- Siddik ZH, Barnes RD, Dring LG, Smith RL, Williams RT. The metabolism of lysergic acid DI[14C]ethylamide ([14C]LSD) in the isolated perfused rat liver. Biochem Pharmacol 28(20):3081-91, 1979. e-Pub 1979. PMID: 518707.
- Siddik ZH, Drew R, Gram TE. The effect of chlorpromazine on the uptake and efflux of paraquat in rat lung slices. Toxicol Appl Pharmacol 50(3):443-50, 1979. e-Pub 1979. PMID: 516057.
- Mimnaugh EG, Siddik ZH, Trush MA, Drew R, Gram TE. The effect of unilateral pneumonectomy on in vitro drug metabolism by the contralateral lung of rabbits. Drug Metab Dispos 7(4):208-10, 1979. e-Pub 1979. PMID: 39721.
- Drew R, Siddik ZH, Gram TE. Uptake and efflux of 14C-paraquat by rat lung slices: the effect of imipramine and other drugs. Toxicol Appl Pharmacol 49(3):473-8, 1979. e-Pub 1979. PMID: 473214.
- Mimnaugh EG, Siddik ZH, Drew R, Sikic BI, Gram TE. The effects of alpha-tocopherol on the toxicity, disposition, and metabolism of adriamycin in mice. Toxicol Appl Pharmacol 49(1):119-26, 1979. e-Pub 1979. PMID: 473197.
- Siddik ZH, Sikic BI, Drew R, Mimnaugh EG, Litterst CL, Gram TE. Lack of correlation between cortisol-induced precocious maturation of the fetal rabbit lung and drug metabolism. Biochem Pharmacol 28(5):683-5, 1979. e-Pub 1979. PMID: 444254.
- Siddik ZH, Barnes RD, Dring LG, Smith RL, Williams RT. The fate of lysergic acid di[ 14C]ethlamide ([14-C]LSD) in the rat. Biochem Soc Trans 3(2):290-2, 1975. e-Pub 1975. PMID: 1132562.
- Subramaniam B, Siddik ZH, Nagoor NH. Development and validation of a reversed-phase HPLC method for quantification of 1’-acetoxychavicol acetate content in a nanostructured lipid carrier formulation. Br J Pharm Sci,.
Invited Articles
- Farooqi AA, Siddik ZH. Platelet-derived growth factor (PDGF) signalling in cancer: rapidly emerging signalling landscape. Cell Biochem Funct 33(5):257-65, 2015. e-Pub 2015. PMID: 26153649.
- Siddik ZH. Agents targeting apoptosis take center stage in the battle against cancer. J. Rashid Latif Med Coll 2(1):7-9, 2013. e-Pub 2013.
- Siddik ZH. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 22(47):7265-79, 2003. e-Pub 2003. PMID: 14576837.
- Siddik ZH. Biochemical and molecular mechanisms of cisplatin resistance. Cancer Treat Res 112:263-84, 2002. e-Pub 2002. PMID: 12481720.
- Pusztai L, Siddik ZH, Mills GB, Bast RC. Physiologic and pathologic drug resistance in ovarian carcinoma--a hypothesis based on a clonal progression model. Acta Oncol 37(7-8):629-40, 1998. e-Pub 1998. PMID: 10050979.
- Newman RA, Siddik ZH. In situ localization and quantitation of anticancer drugs. The Cancer Bulletin 46:67- 71, 1994. e-Pub 1994.
- Siddik ZH, Newman RA. Metabolism of new anticancer agents. Pharmacol Ther 41(1-2):163-94, 1989. e-Pub 1989. PMID: 2652150.
Other Articles
- Subramaniam B, Siddik ZH, Nagoor NH Optimization of nanostructured lipid carriers: understanding the types, designs, and parameters in the process of formulations. J Nanopart Res 22(141), 2020.
- Farooqi AA, de la Roche M, Djamgoz MBA, Siddik ZH Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights. Semin Cancer Biol 58:65-79, 2019. PMID: 30633978.
- Martinez-Rivera M, Siddik ZH Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53. Biochem Pharmacol 83(8):1049-62, 2012. PMID: 22227014.
- Siddik ZH, Hagopian GS, Thai G, Tomisaki S, Toyomasu T, Khokhar AR Role of p53 in the ability of 1,2-diaminocyclohexane-diacetato-dichloro-Pt(IV) to circumvent cisplatin resistance. J Inorg Biochem 77(1-2):65-70, 1999. PMID: 10626356.
- Kudelka AP, Siddik ZM, Balat O, Kavanagh JJ Carboplatin dosimetry in renal failure. J Clin Oncol 13(8):2147-8, 1995. PMID: 7636563.
- Siddik ZH, Edwards MJ, Boddie AW Isolated limb perfusion with chemotherapeutic agents for melanoma: a reevaluation of drug dosimetry. Eur J Cancer Clin Oncol 25(10):1393-7, 1989. PMID: 2687001.
Editorials
- Siddik ZH, Tomasovic SP. Hot Topic Editorial Comment: Mammalian cells adapted to growth at pH 6.7 have elevated HSP27 levels and are resistant to cisplatin, by Wachsberger et al. Int. J. Hyperthermia 13:257-259, 1997.
Abstracts
- Steino A, He G, Zhai B, Bacha JA, Brown DM, Daugagard M, Siddik ZH. VAL-083 (dianhydrogalactitol) synergizes with PARP inhibitors in BRCA-proficient and BRCA-deficient ovarian cancer models. AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics 20(12), 2021. e-Pub 2021.
- He G, Thiabaud G, Shelton K, Segura L, Sessler JL, Finch R, Siddik ZH, Arambula JF. Preclinical tissue biodistribution and plasma pharmacokinetic studies with oxaliTEX, a novel platinum(IV)-based oxaliplatin prodrug. AACR Virtual Annual Meeting 2021 (#1073) 81(13), 2021. e-Pub 2021.
- Sessler J L, Arambula J F, Thiabaud G, Siddik H Z. Preclinical Studies of OxaliTEX. International Symposium on Macrocyclic and Supramolecular Chemistry, 2020. e-Pub 2020.
- SiddikZH. The perils and possibilities of p53-based personalized cancer therapy. International Santorini Conference on Systems Medicine and Personalized Health and Therapy, 2018. e-Pub 2018.
- Ozcan G, Leylek O, Ozcan G, He G, Siddik H Z. The role of p53 and drug uptake in cell density-dependent cisplatin resistance in ovarian cancer cells. Multidisciplinary Cancer Research and Basic Oncology Congress, 2018. e-Pub 2018.
- BachaJ, HeG, SteinoA, BrownD, SiddikZ. Dianhydrogalactitol (VAL-083) has a distinct mechanism of action that suggests combination with PARP inhibitors as an effective therapeutic strategy. AACR 2018 Annual Meeting, 2018. e-Pub 2018.
- Steino A, He G, Zhai B, Bacha JA, Lu S, Brown DM, Daugagard M, Siddik ZH. Assessment of dianhydrogalactitol (VAL-083) in the treatment of relapsed or refractory non-small cell lung cancer. 17th World Conference on Lung Cancer, 2016. e-Pub 2016.
- Steino A, He G, Zhai B, Bacha JA, Lu S, Brown DM, Daugagard M, Siddik ZH. Assessment of dianhydrogalactitol in the treatment of relapsed or refractory non-small cell lung cancer. AACR New Horizons in Cancer Research: Delivering Cures Through Cancer Science 2016, 2016. e-Pub 2016.
- Steino A, Michelle-Martinez M, He G, Xie X, Bacha JA, Brown DM, Siddik ZH. Activity of dianhydrogalactitol (VAL-083) in ovarian tumor models, sensitive or resistant to cisplatin. AACR 11th Biennial Ovarian Cancer Research Symposium, 2016. e-Pub 2016.
- Steino A, He G, Michelle-Martinez M, Bacha JA, Brown D, Siddik ZH. Enhanced in vitro activity of dianhydrogalactitol (VAL-083) in combination with platinum drugs: impact of p53 and platinum-resistance. AACR 107th Annual Meeting, 2016. e-Pub 2016.
- Steino A, He G, Bacha JA, Kanekal S, Brown D, Siddik ZH. In vitro activity of dianhydrogalactitol alone or with platinum drugs in the treatment of non-small cell lung cancer. AACR 106th Annual Meeting 2015, Philadelphia, 2015. e-Pub 2015.
- Bacha JA, Martinez-Rivera M, He G, Xie X, Steino A, Kanekal S, Brown DM, Siddik ZH. A comparison of the mechanisms and cytotoxic activity of dianhydrogalactitol (VAL-083) to cisplatin in ovarian tumor models harboring wild-type and mutant. AACR Advances in Ovarian Cancer, 2015. e-Pub 2015.
- Steino A, He G, Bacha JA, Kanekal S, Brown DM, Siddik ZH. Activity of dianhydrogalactitol alone or with platinum drugs against non-small cell lung cancer cell lines. Clin Oncol, 2015. e-Pub 2015.
- Huang Z, He G, Meraz IM, Khokhar AR, Siddik ZH. Gain-of-Resistance to cisplatin and its circumvention in ovarian tumor cells harboring wild type p53. Eur Soc Gyn Oncol-18th Int'l Mtg Liverpool UK, 2013. e-Pub 2013.
- Steino A, Bacha JA, Garner WJ, Kanekal S, Siddik ZH, Brown DM. The unique mechanism of action of VAL-083 may provide a new treatment option for some chemo-resistant cancers. AACR-NCI-EORTC International Conference, Boston, 2013. e-Pub 2013.
- Kim ES, Kilari D, Tang X, Chow CW, Fujimoto J, Kalhor N, Swisher S, Wistuba II, Stewart DJ, Siddik ZH. Copper transporter CTR1 expression and tissue platinum concentration in NSCLC. Lung Cancer 85(1):88-93, 2013. e-Pub 2013. PMID: 24792335.
- Kim ES, He G, C-W C, Fujimoto J Kalhor N, Swisher SG, Wistuba II, Stewart DJ, Siddik ZH. Tissue platinum concentration and tumor response in non-small cell lunch cancer,. Texas Soc Clin Oncol, San Antonio TX, 2011. e-Pub 2011.
- Kim ES, He G, C-W C, Fujimoto J, Kalhor N, Swisher SG, Wistuba II, Stewart DJ, Siddik ZH. Correlation between tissue platinum concentration and tumor response in non-small cell lung cancer. 14th World Conf. on Lung Cancer, Amsterdam, The Netherlands, 2011. e-Pub 2011.
- He G, Kuang J, Kommen J, Kobayashi R, Khokhar AR, Siddik ZH. DNA damage by platinum-based drugs induces P21-dependent recruitment of PCNA as a homotrimer into the inhibited G-1 phase CDK complex. Proc. Am Assoc Cancer Res, 2011. e-Pub 2011.
- Meraz IM, Khokhar A, Siddik ZH. Defective Check Point Kinase 2 (Chk2) Expression in Cisplatin-resistant Ovarian Tumor Cells Impedes wild-type P53 function. Proc. Am. Assoc. Cancer Res 51, 2010. e-Pub 2010.
- He G, Kuang J, Khokhar AR, Siddik ZH. The underlying basis for divergent cell cycles kinetics following checkpoint activation by cisplatin and a platinum (IV) analog. Am Assoc Cancer Res 51, 2010. e-Pub 2010.
- He G, Kuang J, Khokhar AR, Siddik ZH. The paradox in cell cycle effects of cisplatin; failure of tumor cells to accumulate in G1 following activation of G1-checkpoint proc. 13th World Congress on Advances in Oncology and 11th Int'l symposium on Molecular Medicine, 2010. e-Pub 2010.
- Huang Z, He G, Khokhar A, Siddik ZH. Paradoxical molecular changes in cisplatin-resistant ovarian tumor cells: up-regulation of drug-sensitizing and down-regulation of resistance-inducing genes. Proc Am Assoc Cancer Res 50, 2009. e-Pub 2009.
- Huang Z, He G, Khokhar AR, Siddik ZH. Molecular profiling of an isogenic sensitive-resistant pair of ovarian tumor cell lines identifies hepatocyte growth factor as downregulated in cisplatin resistance. Proc Am Assoc Cancer Res, 2008. e-Pub 2008.
- Siddik ZH. A rational microarray approach to investigate the paradox of wild-type p53 in refractory cancers. Proc. 13th World Congress on Advances in Oncology and 11th Int’l Symposium on Molecular Medicine, 2008. e-Pub 2008.
- Lu Y, Li X, Liang K, Luwor R, Siddik ZH, Mills GB, Mendelsohn J, Fan Z. Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance to the anti-EGFR monoclonal antibody cetuximab. Proc Am Assoc Cancer Res (98th Annu. Mtg. Amer. Assoc. Cancer Res., April 14-18, Los Angeles, California) 48, 2007. e-Pub 2007.
- Strebel FR, Siddik ZH, Deng W, Rowe RW, Bull JMC. Long-duration, fever-range, thermal therapy increases oxaliplatin-induced cell-kill, cellular platinum uptake, and formation of platinum-DNA adducts in breast cancer cells. Proc World Conference on Interventional Oncology and Society for Thermal Medicine, 2007. e-Pub 2007.
- Tavana B, Huang ZF, Khokhar A, Bornmann WG, Siddik ZH. Downregulation of p21 induces cisplatin resistance in tumor cells harboring wild-type p53. Proc Am Assoc Cancer Res 48, 2007. e-Pub 2007.
- Kurokawa T, Siddik ZH. Effect of casein kinase 2 (ck2) inhibitors on antitumor activity of cisplatin in an isogenic pair of sensitive and resistant ovarian tumor cell lines. Proc Am Assoc Cancer Res 48, 2007. e-Pub 2007.
- Siddik ZH, He G, Watanabe M, Mujoo K, Khokhar AR, Kuang J. Circumvention of drug resistance in human tumors harboring wild-type p53. Proc Am Assn Cancer Res 47, 2006. e-Pub 2006.
- Siddik ZH, He G, Koomen J, Kobayashi R, Z-F H, Khokhar AR, Kuang J. p27 changes its binding to the Cdk4 and Cdk2 complexes during DAP-induced G1-phase checkpoint response. Proc Am Assn Cancer Res 46:Abs 2273, 2005. e-Pub 2005.
- Song I, Savaraj N, Siddik ZH, Liu P, Wei Y, Wu CJ, Kuo MT. Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells. Proc Am Assn Cancer Res 46:Abs 1483, 2005. e-Pub 2005.
- Siddik ZH, He G, Koomen J, Kobayashi R, Z-F H, Khokhar AR, Kuang J. Molecular and proteomic analysis of Cdk4 and Cdk2 complexes following G1-phase checkpoint response to DNA damage. Proc Am Assn Cancer Res 45:Abs 2333, 2004. e-Pub 2004.
- Siddik ZH, He G, Koomen J, Kobayashi R, Z-F H, Khokhar AR, Kuang J. Biochemical and proteomic characterization of Cdk4 and Cdk2 complexes formed in response to G1-phase checkpoint activation by a platinum-based drug. International Platinum Symposium, New York, 2003. e-Pub 2003.
- Sumiyoshi Y, Ojima H, Mujoo K, Kondo Y, L-L S, J-PJ I, Ghosh S, Farquhar D, Khokhar AR, Siddik ZH. Influence of p53 on the role of mismatch repair in cisplatin resistance and cross-resistance to other antitumor agents. AACR-NCI-EORTC International Conference, Boston, 2003. e-Pub 2003.
- Sumiyoshi Y, Ojima H, Mujoo K, Khokhar AR, Siddik ZH. Cross-resistance patterns of DNA-interactive agents in cisplatin-resistant ovarian cancer. Proc Am Assn Cancer Res 44, 2003. e-Pub 2003.
- Sumiyoshi Y, Ojima H, Mujoo K, Khokhar AR, Siddik ZH. Significance of mismatch repair in cisplatin resistance and induction of cross-resistance to diverse DNA-damaging antitumor drugs. International Platinum Symposium, New York, 2003. e-Pub 2003.
- Watanabe M, Mujoo K, Khokhar AR, Siddik ZH. Circumventing mechanisms of drug resistance in breast tumor cells overexpressing HER2/neu. Department of Defense Era of Hope Conference, Orlando, FL, 2002. e-Pub 2002.
- He G, Siddik ZH, Huang Z, Wu W, Pan S, Khokhar AR, Kuang J. Mechanism of inhibition of Cdk4 and Cdk2 activities in the G1 phase checkpoint response induced by the DNA-damaging agent DACH-acetato-Pt. Proc Am Assn Cancer Res 43:797, 2002. e-Pub 2002.
- Ojima H, Watanabe M, Mujoo K, Hennessey P, Khokhar AR, Siddik ZH. Oxaliplatin resistant human ovarian tumor cells have low cross-resistance to the platinum analog DACH-Ac-Pt. Proc Am Assn Cancer Res 43:424, 2002. e-Pub 2002.
- Kuang J, He G, Huang Z, Khokhar AR, Siddik ZH. Differential effects of cisplatin and its analog DACH-acetato-Pt on the p53-p21 signaling pathway. Proc Am Assn Cancer Res 43:795, 2002. e-Pub 2002.
- Mujoo K, Watanabe M, Hennessey P, Khokhar AR, Siddik Z H. Cytotoxicity of the platinum complex DACH-AC-Pt against refractory human prostate cancer cells. Proc Am Assn Cancer Res 43:260-261, 2002. e-Pub 2002.
Book Chapters
- Siddik ZH. Alkylating Agents and Platinum Antitumor Compounds. In: In: Holland-Frei Cancer Medicine. 9th, Ch. 58, pp 649-664, 2017.
- Siddik ZH. Apoptosis in cancer: mechanisms, deregulation, and therapeutic targeting. In: Cancer Drug Design and Discovery. 2nd, 357-390, 2014.
- Siddik ZH. Targeting p21-dependent pathways for cell death in cancer therapy. In: Checkpoint Controls and Targets in Cancer Therapy. Humana Press, 199-213, 2010.
- Siddik ZH. Drug resistance and the tumor suppressor p53: The paradox of wild-type genotype in chemorefractory cancers. In: Drug Resistance in Cancer Cells. Humana Press, 209-231, 2009.
- Siddik ZH. Cisplatin resistance: Molecular basis of a multifaceted impediment. In: Cancer Drug Discovery and Development: Cancer Drug Resistance. Humana Press, pp. 283-307, 2006.
- Siddik ZH. Mechanism of action of cancer chemotherapeutic agents: DNA-interactive alkylating agents and antitumor platinum-based drugs. In: The Cancer Handbook. Macmillan Publishers, pp. 1295-1311, 2002.
- Siddik ZH. Biochemical and molecular mechanisms of cisplatin resistance. In: Clinically Relevant Drug Resistance to Anticancer Agents. Kluwer Academic Publishers, Inc, pp. 263-284, 2002.
- Prasad SY, Khokhar AR, Siddik ZH. Potentiation by L-buthionine sulfoximine (BSO) of cytotoxicity of platinum(IV) complexes in sensitive and resistant human ovarian carcinoma cells. In: Metal Ions in Biology and Medicine. John Libbey, pp. 365-370, 1994.
- Siddik ZH, Newman RA. Metabolism of new anticancer agents. In: International Encyclopedia of Pharmacology and Therapeutics - Anticancer Drugs: Antimetabolite Metabolism and Natural Anticancer Agents. Pergamon Press, pp. 437-480, 1994.
- Perez-Soler R, Siddik ZH, Vadiei K, Krakoff IH, Khokhar AR. Pharmacological studies with new liposome- entrapped cisplatin derivatives. In: Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Plenum Press, pp. 377-389, 1991.
- Harrap KR, Jones M, Goddard PM, Orr RM, Siddik ZH. Drug resistance as a focus for new drug design. In: Mechanisms of Drug Resistance in Neoplastic Cells. Academic Press, pp. 307-328, 1988.
- Siddik ZH, Newell DR. Radiochemicals in cancer research and clinical oncology. In: Critical Reports on Applied Chemistry: Biomedical Research Using Radiochemicals - Current and Future Trends. John Wiley & Sons Ltd, pp. 118- 150, 1988.
- Siddik ZH, Boxall FE, Harrap KR. Tissue solubilization in hyamine hydroxide for the flameless atomic absorption spectrophotometric determination of platinum. In: Biochemical Mechanisms of Platinum Antitumour Drugs. IRL Press, pp. 361-366, 1986.
- Siddik ZH, Dible SE, Boxall FE, Harrap KR. Renal pharmacokinetics and toxicity of cisplatin and carboplatin in animals. In: Biochemical Mechanisms of Platinum Antitumour Drugs. IRL Press, pp. 171-198, 1986.
- Newell DR, Siddik ZH, Harrap KR. HPLC analysis of cisplatin analogues in biological fluids. In: Methodological Surveys in Biochemistry and Analysis: Drug Determinations in Therapeutic and Forensic Contexts. Plenum, pp. 145-153, 1984.
- Siddik ZH, Newell DR, Boxall FE, Jones M, McGhee KG, Harrap KR. Biliary excretion, renal handling, and red cell uptake of cisplatin and CBDCA in animals. In: Platinum Coordination Complexes in Cancer Chemotherapy. Martinus Nijhoff, pp. 90-102, 1984.
- Siddik ZH, Trush MA, Gram TE. Absorption and distribution of drugs. In: Modern Pharmacology. Little Brown and Co, pp. 20-36, 1982.
- Siddik ZH, Mimnaugh EG, Trush MA, Gram TE. Hepatic and extrahepatic glutathione S-transferase activities in Vitamin A deficiency. In: Microsomes, Drug Oxidations and Chemical Carcinogenesis. Academic Press, pp. 679-682, 1980.
- Gram TE, Sikic BI, Litterst CL, Mimnaugh EG, Drew R, Siddik ZH. The role of the lung in the metabolism and disposition of xenobiotics. In: Industrial and Environmental Xenobiotics, pp. 53-58,, 1978.
- Siddik ZH. Alkylating Agents and Platinum Antitumor Compounds. In: In: Holland-Frei Cancer Medicine. 10th.
Books (edited and written)
- Boonstra J, Bunz F, Kuang J, Kramer A, Xiong Y, Lee MH, Nakanishi M, Alao JP, Lozano G, Giordano A, Friedenson B, Kaina B, Pevarello P, Eastman A, Siddik ZH, Bast R, Zhang H, Taylor SS, Rudolph J. Checkpoint Controls and Targets in Cancer Therapy. Humana Press, 2010.
- Bates S, Fidler IJ, Kondo Y, Reddy EP, Mehta K, Hodkinson PS, Huang P, Aggarwal BB, Siddik ZH, Ali-Osman F, Ozoplat B, Calin G, Troester M, Price P, Chan MM. Drug Resistance in Cancer Cells. Humana Press, 2009.
Selected Presentations & Talks
Local Presentations
- 2005. Speaker, Faculty Compensation Committee: SAP: Facts and Fiction. Conference. Speaker, Faculty Compensation Committee: SAP: Facts and Fiction. Houston, TX, US.
- 2005. Speaker, Faculty Compensation Committee: Benchmark Comparisons. Conference. Speaker, Faculty Compensation Committee: Benchmark Comparisons. Houston, TX, US.
- 2005. Invited Speaker, Targeting Wild-Type p53 in Refractory Cancers. Conference. Invited Speaker, Targeting Wild-Type p53 in Refractory Cancers. Houston, TX, US.
- 2003. Speaker, Faculty Compensation Sub-Committee: Review of Salary Analysis for Faculty and Administrators. Conference. Speaker, Faculty Compensation Sub-Committee: Review of Salary Analysis for Faculty and Administrators. Houston, TX, US.
- 2001. Speaker, Faculty Compensation Advisory Committee: Faculty Compensation Project – The Towers Perrin Report. Conference. Speaker, Faculty Compensation Advisory Committee: Faculty Compensation Project – The Towers Perrin Report. Houston, TX, US.
- 1999. Speaker, Faculty Compensation Advisory Committee: Faculty Compensation Project Update. Conference. Speaker, Faculty Compensation Advisory Committee: Faculty Compensation Project Update. Houston, TX, US.
- 1998. Speaker, Faculty Compensation Advisory Committee: Faculty Compensation Project. Conference. Speaker, Faculty Compensation Advisory Committee: Faculty Compensation Project. Houston, TX, US.
National Presentations
- 2024. Cancer Research. Conference. AACR Annual Meeting 2024. San Diego, CA, US.
- 2023. Cancer Research. Conference. AACR Annual Meeting 2023. Orlando, FL, US.
- 2020. Cancer Research. Conference. 2020 Virutal Annual AACR Meeting, US.
- 2019. Cancer Research. Conference. Cancer Research. Atlanta, GA, US.
- 2003. Speaker and Session Chair, Mechanism of Platinum Resistance. Conference. AACR Poster Discussion Presentation. Washington, DC, US.
- 1999. Invited Speaker, Developing new cancer therapeutic agents to target p53 dysfunction. Conference. Cancer Therapeutics Discovery Program Scientific Symposium. Houston, TX, US.
- 1997. Circumvention of DNA damage tolerance through activation of p53 Function. Conference. Cancer Therapeutics Discovery Program Workshop IV. Houston, TX, US.
- 1996. Invited Speaker, Development of platinum-based drugs. Conference. Past Success and Future Strategy, Cancer Therapeutics Discovery Program Workshop II. Houston, TX, US.
- 1996. Invited Speaker, Development of carboplatin and RMP-7 combination for brain tumors. Conference. Workshop on Novel Applications of Carboplatin. Tampa, FL, US.
- 1994. Invited Speaker, Clinical pharmacology of enloplatin. Conference. American College of Clinical Pharmacology’s 23rd Annual Meeting, October 6-8. Orlando, FL, US.
- 1992. Section of Drug Metabolism & Disposition. Conference. Lilly Research Laboratories. Indianapolis, IN, US.
- 1991. Invited Speaker, Pharmacokinetic-pharmacodynamic considerations in the development of platinum complexes. Conference. Workshop on New Platinum Complexes. Pearl River, NY, US.
- 1991. Medical Research Division. Conference. Lederle Laboratories. Pearl River, NY, US.
- 1985. Invited Speaker, Aspects of the experimental pharmacology of carboplatin. Conference. Workshop on New Antitumor Agents in Development. Philadelphia, PA, US.
International Presentations
- 2023. Paradox of the wild P53 in refractory ovarian carcinoma. Conference. Paradox of the wild P53 in refractory ovarian carcinoma. Mar del Plata, AR.
- 2015. Mechanism-based design of platinum-based complexes as therapeutic agents for targeting refractory cancers, Exploring New Avenues in Medicinal Chemistry. Conference. Mechanism-based design of platinum-based complexes as therapeutic agents for targeting refractory cancers, Exploring New Avenues in Medicinal Chemistry, PK.
- 2011. The Good, the Bad and the Ugly Sides of the p53 Tumor Suppressor in Cancer Therapy. Conference. 4th International Conference of Translational Cancer Research. Udaipur, IN.
- 2010. The paradox in cell cycle effects of cisplatin: Failure of tumor cells to accumulate in G1 following activation of G1-checkpoint. Conference. 15th World Congress on Advances in Oncology. Loutraki, GR.
- 2008. A Rational Microarray Approach to Investigate the Paradox of Wild-Type p53 in Refractory Cancers. Conference. 13th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine. Hersonissos, GR.
- 2004. Invited Speaker, The Mechanism of Selective Inhibition of G1-Phase Cdk4/cyclin D and Cdk2/cyclin E Complexes in Response to Checkpoint Activation by an Analog of Cisplatin. Conference. 9th World Congress on Advances in Oncology and 7th International Symposium on Molecular Medicine, October 16-19. Crete, GR.
- 2000. Invited Speaker, Therapeutic Antitumor Agents Targeting p53, 5th World Congress on Advances in Oncology. Conference. 3rd International Symposium on Molecular Medicine. Crete, GR.
- 1999. Invited Speaker, Chemical and biochemical approaches designed to circumvent cisplatin Resistance. Conference. 4th World Congress on Advances in Oncology and 2nd International Symposium on Molecular Medicine, October 7-9. Athens, GR.
- 1999. Invited Speaker, Relationship between DNA damage tolerance and p53 functional status for cisplatin and 1R,2R-diaminocyclohexane-diacetato-dichloro-platinum(IV) (DACH-Acetato-Pt). Conference. 8th International Symposium on Platinum Metal Coordination Compounds in Cancer Chemotherapy. March 29-31. Oxford, GB.
- 1998. Invited Speaker, The role of p53 in the onset and circumvention of cisplatin resistance. Conference. 3rd World Congress on Advances in Oncology and 1st International Symposium on Molecular Medicine, October 15-17. Crete, GR.
- 1992. Invited Speaker, Platinum-based antitumor agents in development. Conference. Second International Symposium on Transition Metals in Chemotherapy, September 22-24. Bristol, GB.
- 1990. Invited Speaker, Pharmacologically guided development of platinum complexes. Conference. 15th International Cancer Congress (UICC), August 16-22. Hamburg, DE.
- 1990. Invited Speaker, Pharmacokinetics of platinum complexes. Conference. First International Conference on Platinum Complexes and Liposomes in the Treatment of Cancer. Barcelona, ES.
- 1989. Invited Speaker, Analytical techniques in pharmacological studies of platinum-containing antitumor agents. Conference. XXVII International Conference on Coordination Chemistry: Symposium on Metal Complexes in the Detection and Treatment of Cancer, July 10-14. Marysville, AU.
- 1986. Invited Speaker, Species difference in drug absorption, distribution and elimination as a pitfall in using preclinical pharmacokinetics for toxicity prediction in man. Conference. EORTC Pharmacokinetics and Metabolism Group Symposium: Prediction of Toxicity in Phase I Trials Based on Preclinical and Clinical Pharmacokinetics, June 12-14. Edinburgh, GB.
- 1985. Invited Speaker, Tissue solubilization in hyamine hydroxide for the flameless atomic absorption spectrophotometric determination of platinum. Conference. International Cancer Research Symposium: Biochemical Mechanisms of Platinum Antitumour Drugs, July 3-5. Uxbridge.
- 1985. Invited Speaker, Renal pharmacokinetics and toxicity of cisplatin and carboplatin in animals. Conference. International Cancer Research Symposium: Biochemical Mechanisms of Platinum Antitumour Drugs, July 3-5. Uxbridge.
- 1983. Invited Speaker, Biliary excretion, renal handling and red cell uptake of cisplatin and CBDCA. Conference. 4th International Symposium on Platinum Coordination Complexes in Cancer Chemotherapy. Burlington, US.
Formal Peers
- 2012. Tumor Suppressor p53 and Drug Response: The Good, The Bad and The Ugly. Invited. Tumor Suppressor p53 and Drug Response: The Good, The Bad and The Ugly. Ontario, CA.
- 2005. Speaker, Wild-Type p53 as a Checkpoint Response and Therapeutic Target in Refractory Cancers. Invited. Speaker, Wild-Type p53 as a Checkpoint Response and Therapeutic Target in Refractory Cancers. Santa Clara, CA, US.
- 1998. Lecturer. Visiting. Lecturer. London, GB.
- 1994. Visiting Professor. Visiting. Visiting Professor. Fukuoka, JP.
- 1992. Pharmacology Seminars. Invited. Pharmacology Seminars. Houston, TX, US.
- 1989. Department of Pharmacology. Invited. Department of Pharmacology. Houston, TX, US.
- 1987. Pharmacology Seminar Series. Invited. Pharmacology Seminar Series. Rochester, MN, US.
- 1981. Lecturer. Visiting. Lecturer. London, GB.
Grant & Contract Support
Date: | 2024 - 2027 |
Title: | RA230306 - Mechanism-Based Targeting of MDM2 and G1-CDK for Therapy of Rare Refractory Ovarian Cancer Subtypes |
Funding Source: | Department of Defense (DOD) |
Role: | PI |
Date: | 2024 - 2026 |
Title: | Utility of PARP Inhibitors in Rare Refractory Ovarian Cancer Sub-Types |
Funding Source: | NIH/NCI |
Role: | PI |
Date: | 2023 - 2025 |
Title: | Targeting MDM4 in Rare Refractory Ovarian Cancer Sub-Types |
Funding Source: | NIH/NCI |
Role: | PI |
ID: | GRANT13803145 |
Date: | 2023 - 2028 |
Title: | Unmasking Conserved Phospho-sites for Wild-type p53 Activation in Refractory Cancers |
Funding Source: | NIH/NCI |
Role: | PI |
ID: | 1R01CA279055-01 |
Date: | 2022 - 2024 |
Title: | Molecular Mechanism of OxaliTex |
Funding Source: | Sponsored Research Agreement |
Role: | PI |
ID: | RCTS# LS2022-00060252-RP |
Date: | 2021 - 2026 |
Title: | Targeting wild-type p53 in refractory cancers |
Funding Source: | NIH/NCI |
Role: | PI |
ID: | 1R01CA266508-01 |
Date: | 2021 - 2024 |
Title: | RA200395 - Rational restoration of p53-dependent antitumor drug response in chemoresistant rare ovarian cancer subtype |
Funding Source: | Department of Defense (DOD) |
Role: | PI |
ID: | GRANT13249696 |
Date: | 2021 - 2022 |
Title: | Eclipse High Performance Mass Spectrometer for Proteomics |
Funding Source: | NIH/NIGMS |
Role: | Major User |
ID: | 1 S10 OD030382-01 |
Date: | 2020 - 2022 |
Title: | Targeting MDM2 in Mesothelioma |
Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
Role: | PI |
ID: | CA190615 |
Date: | 2020 - 2025 |
Title: | Role of DCLK1 in Promoting Chemo Resistance in Ovarian Cancer |
Funding Source: | NIH/NCI |
Role: | Mentor |
ID: | FP00008617 |
Date: | 2020 - 2023 |
Title: | Pharmacologic modulation of p53 dynamics to enhance therapeutic response in refractory cancers |
Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
Role: | PI |
ID: | RP200344 |
Date: | 2019 - 2022 |
Title: | BC180537: Enhanced Therapeutic Targeting of Cell Cycle in Breast Cancer |
Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
Role: | Co-I |
ID: | BC180537 |
Date: | 2019 - 2022 |
Title: | OC180080: Enhanced Therapeutic Targeting of Mitosis in Ovarian Cancer |
Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
Role: | Co-I |
ID: | OC180080 |
Date: | 2019 - 2024 |
Title: | Targeting Wild-Type p53 in Chemoresistant Rare Ovarian Cancers |
Funding Source: | NIH/NCI |
Role: | PI |
ID: | 1R01CA244385-01 |
Date: | 2019 - 2024 |
Title: | Wip1 Phosphatase and Platinum Drug Response |
Funding Source: | NIH/NCI |
Role: | PI |
ID: | 1 R01 CA238289-01 |
Date: | 2019 - 2022 |
Title: | Enhancing mitotic cell death by a novel drug combination |
Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
Role: | Co-I |
Date: | 2019 - 2020 |
Title: | An Orbitrap Fusion Lumos for Advanced Proteomics and Metabolomics - instrumentation grant program |
Funding Source: | NIH/NCI |
Role: | Minor User |
ID: | 1 S10 OD026894-01 |
Date: | 2018 - 2023 |
Title: | Enhancing mitotic cell death in cancer therapy |
Funding Source: | NIH/NCI |
Role: | Co-I |
ID: | GRANT12555118 |
Date: | 2018 - 2023 |
Title: | Targeted Development of Platinum Drug Combinations |
Funding Source: | NIH/NCI |
Role: | PI |
ID: | 2R01CA160687-06 |
Date: | 2017 - 2018 |
Title: | Synergizing a first-in-class DNA targeting agent with PARP inhibition for cisplatin-resistant ovarian cancer |
Funding Source: | NIH/NCI Small Business Technology Transfer (STTR) |
Role: | Co-I |
Date: | 2017 - 2023 |
Title: | Cell Cycle Blockade and Therapeutic Sensitization |
Funding Source: | NIH/NCI |
Role: | PI |
ID: | 5R01CA211975 |
Date: | 2017 - 2018 |
Title: | Activation of dysfunctional wild-type p53 in drug-resistant non-small cell lung cancer as a therapeutic strategy |
Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
Role: | PI |
ID: | LC160609 |
Date: | 2017 - 2022 |
Title: | Cell Cycle Blockade and Therapeutic Sensitization |
Funding Source: | NIH/NCI |
Role: | PI |
ID: | 1R01CA211975-01 |
Date: | 2016 - 2019 |
Title: | Selective protection of cisplatin-induced renal injury in the therapy of refractory ovarian cancers |
Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
Role: | PI |
ID: | PR161325 |
Date: | 2016 - 2021 |
Title: | Targeting MDM4 in Chemoresistant Cancers |
Funding Source: | NIH/NCI |
Role: | PI |
ID: | 1R01CA205251-01 |
Date: | 2016 - 2019 |
Title: | Rewiring the MDM4 Circuitry to Activate p53 in Chemoresistant Tumor Cells |
Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
Role: | PI |
ID: | RP160469 |
Date: | 2015 - 2018 |
Title: | Pre-IND Development of OxaliTex |
Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
Role: | PI |
ID: | DP150087 |
Date: | 2014 - 2015 |
Title: | Center for Inflammation Systems Pharmacology |
Funding Source: | Methodist Hospital Research Institute |
Role: | Co-I |
ID: | 1P50GM107611-01 |
Date: | 2014 - 2017 |
Title: | Identification and Characterization of Novel Anti-Inflammatory Agents from Turmeric |
Funding Source: | (Curcuma Longa) |
Role: | PI |
Date: | 2014 - 2015 |
Title: | Targeted stabilization of wild-type p53 for lung cancer therapy |
Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
Role: | PI |
Date: | 2014 - 2016 |
Title: | Activity of VAL-083 as a Novel Chemotherapy for TMZ-Resistant GBM Patients - NIH Small Business Technology Transfer (STTR) |
Funding Source: | Dept of Energy/Del Mar Pharmaceuticals |
Role: | PI |
Date: | 2014 - 2019 |
Title: | Checkpoint Response and Platinum Drug Sensitivity |
Funding Source: | NIH/NCI |
Role: | PI |
ID: | RO1 CA127263 |
Date: | 2014 - 2019 |
Title: | Core Project 3 |
Funding Source: | Computational Systems Biology-Center for Inflammation Systems Pharmacology |
Role: | Co-PI |
ID: | P50 GM107611-01 |
Date: | 2013 - 2017 |
Title: | Biochemical and Molecular Pharmacology of VAL-083 |
Funding Source: | Del Mar Pharmaceuticals |
Role: | PI |
Date: | 2012 - 2015 |
Title: | Cisplatin Resistance in Ovarian Cancer Harboring Wild-Type p53 |
Funding Source: | National Science Foundation (NSF) |
Role: | Mentee - Michelle Martinez |
Date: | 2012 - 2014 |
Title: | The Underlying Basis for Supra-Resistance in Malignant Mesothelioma |
Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
Role: | PI |
Date: | 2012 - 2014 |
Title: | CTR1 Transporter Dysregulation in Platinum Resistant NSCLC - Young Investigator Award, Conquer Cancer Foundation |
Funding Source: | American Society of Clinical Oncology (ASCO) |
Role: | Mentee -Kim |
Date: | 2011 - 2014 |
Title: | Preclinical Development of Texaphyrin-Platinum Conjugates |
Funding Source: | CPRIT |
Role: | Principal Investigator (Sub-Contractor) |
ID: | RP120393 01 |
Date: | 2011 - 2017 |
Title: | Targeted Development of Platinum Drugs |
Funding Source: | NIH/NCI |
Role: | PI |
ID: | 1R01CA160687-01 |
Date: | 2011 - 2013 |
Title: | Development of Texaphyrin-Platinum Conjugates |
Funding Source: | American Cancer Society (ACS) |
Role: | Mentor |
Date: | 2010 - 2015 |
Title: | Platinum Resistance and the Tumor Suppresor p53 |
Funding Source: | NIH/NCI |
Role: | PI |
ID: | 1 RO1 CA148741-01A1 |
Date: | 2010 - 2011 |
Title: | Transrepression of Survivin as a Therapeutic Strategy in Advanced Breast Cancer |
Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
Role: | PI |
ID: | BC097172 |
Date: | 2010 - 2013 |
Title: | Wild-type p53 as a target of therapy in malignant mesothelioma |
Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
Role: | PI |
Date: | 2010 - 2015 |
Title: | Platinum Resistance and the Tumor Suppressor p53 |
Funding Source: | NIH/NCI |
Role: | PI |
Date: | 2010 - 2014 |
Title: | Defective Activation of Wild-type p53 in Chemoresistant Cancers |
Funding Source: | Cancer Prevention and Research Institute of Texas |
Role: | PI |
Date: | 2009 - 2011 |
Title: | G1 Checkpoint Response in Advanced Breast Cancer |
Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
Role: | PI |
Date: | 2009 - 2011 |
Title: | Defining the underlying mechanism of resistance in mesothelioma as a basis for novel therapy in this rare disease |
Funding Source: | NIH/NCI |
Role: | PI |
Date: | 2009 - 2010 |
Title: | Targeting wild-type p53 in refractory breast cancer |
Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
Role: | PI |
ID: | W81XWH-08-BCRP-CA |
Date: | 2009 - 2012 |
Title: | Endogenous wild-type p53 as a therapeutic target in cisplatin-resistant ovarian cancers |
Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
Role: | PI |
ID: | W81XWH-08-OCRP-IDA |
Date: | 2008 - 2010 |
Title: | Platinum-texaphyrin Cisplatin Conjugates and Drug Resistance Interactions |
Funding Source: | CTT/TI-3D |
Role: | Co-PI |
Date: | 2008 - 2013 |
Title: | Waf1/Cip1 as a Target of Therapy in Drug-Resistant Cells |
Funding Source: | NIH/NCI |
Role: | PI |
Date: | 2008 - 2009 |
Title: | Gene Expression Signatures to Define Deregulated Pathways in Refactory Ovarian Cancers |
Funding Source: | Department of Defense (DOD) |
Role: | PI |
Date: | 2008 - 2011 |
Title: | Status of p53-p21 Pathway and Therapeutic Response in Advanced Breast Cancer |
Funding Source: | Department of Defense (DOD) |
Role: | PI |
Date: | 2007 - 2008 |
Title: | Down-regulation of p21 Waf1/Cip1 Promoter Activity in Chemoresistant Breast Cancer |
Funding Source: | Department of Defense (DOD) |
Role: | PI |
Date: | 2007 - 2007 |
Title: | Protein Kinase CK2 as a target in cisplatin-resistant epithelial ovarian cancers |
Funding Source: | Department of Defense Ovarian Cancer Research Program OCRP06 Concept Award |
Role: | PI |
Date: | 2007 - 2014 |
Title: | Checkpoint Response and Platinum Drug Sensitivity |
Funding Source: | NIH/NCI |
Role: | PI |
ID: | RO1 CA127263 |
Date: | 2006 - 2011 |
Title: | Clinical Pharmacology of L-NDDP |
Funding Source: | Antigenics, Inc |
Role: | PI |
ID: | CS2006-00016259LE |
Date: | 2005 - 2010 |
Title: | Training of Academic Gynecologic Oncologists |
Funding Source: | NIH/NCI |
Role: | Mentor |
Date: | 2004 - 2009 |
Title: | Training for Academic Oncology |
Funding Source: | NCI-NIH |
Role: | Mentor |
ID: | T32 CA-09666 |
Date: | 2003 - 2008 |
Title: | Pharmacology and New Drug Development, CCSG Core Grant |
Funding Source: | NIH/NCI |
Role: | Co-Program Leader |
ID: | P30 CA016672 |
Date: | 2001 - 2007 |
Title: | Effects of DNA Damaging Agents on G2 Phase Checkpoint |
Funding Source: | NIH/NCI |
Role: | Co-I |
Date: | 2001 - 2005 |
Title: | Development of DACH-acetato-Pt for an IND Application |
Funding Source: | MDACC CTDP Kleberg Drug Development Grant |
Role: | Co-PI |
Date: | 2000 - 2005 |
Title: | Clinical Oncology Career Development Program |
Funding Source: | NIH |
Role: | Mentor |
Date: | 1999 - 2003 |
Title: | Therapy of Breast Tumor Cells Overexpressing c-erbB-2/neu |
Funding Source: | Department of Defense Breast Cancer Research Program |
Role: | PI |
Date: | 1999 - 2004 |
Title: | Circumvention of Cisplatin Resistance |
Funding Source: | NCI |
Role: | PI |
ID: | RO1 CA82361 |
Date: | 1999 - 2001 |
Title: | JAB1 as a Marker for Anticancer Drug Resistance |
Funding Source: | UTMDACC PRS |
Role: | Co-I |
Date: | 1999 - 2004 |
Title: | Training for Academic Oncology |
Funding Source: | NCI-NIH |
Role: | Mentor |
ID: | T32 CA-09666 |
Date: | 1999 - 2003 |
Title: | Mechanistic Development of Platinum-Based Drugs |
Funding Source: | NCI |
Role: | PI |
ID: | RO1 CA77332 |
Date: | 1998 - 2002 |
Title: | Phase II/III Clinical Trials of Anticancer Agents |
Funding Source: | NCI |
Role: | Co-I |
ID: | UO1 CA70172 |
Date: | 1998 - 2001 |
Title: | c-erbB-2 Overexpression and Platinum Activity in Refractory Ovarian Tumors |
Funding Source: | Sandra G Davis Ovarian Cancer Research Fund |
Role: | PI |
Date: | 1998 - 2003 |
Title: | Correlated Laboratory - Clinical Phase I Drug Development |
Funding Source: | NCI |
Role: | Co-I |
ID: | 5 UO1 CA62461 |
Date: | 1997 - 1999 |
Title: | Pharmacology of Carboplatin in Combination with RMP-7 in the Treatment of Malignant Glioma in a Phase II Study |
Funding Source: | Alkermes, Inc |
Role: | PI |
ID: | LS 97-031 |
Date: | 1995 - 2000 |
Title: | Phase I Clinical Trials of Anticancer Agents |
Funding Source: | NIH/NCI |
Role: | Co-I |
ID: | 5 UO1 CA62461 |
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CV information above last modified March 27, 2025