Zhen Lu, MD

Peer-Reviewed Articles

1. Santiago-O'Farrill JM, Blessing Bollu A, Yang H, Orellana V, Pina M, Zhang X, Liu J, Bast RC Jr, Lu Z. Crizotinib Enhances PARP Inhibitor Efficacy in Ovarian Cancer Cells and Xenograft Models by Inducing Autophagy. Mol Cancer Res 22(9):840-851, 2024. e-Pub 2024. PMID: 38780897.
2. Guo J, Wang C, Luo N, Wu Y, Huang W, Zhu J, Shi W, Ding J, Ge Y, Liu C, Lu Z, Bast RC Jr, Ai G, Yang W, Wang R, Li C, Chen R, Liu S, Jin H, Zhao B, Cheng Z. IL-2-free tumor-infiltrating lymphocyte therapy with PD-1 blockade demonstrates potent efficacy in advanced gynecologic cancer. BMC Med 22(1):207, 2024. e-Pub 2024. PMID: 38769543.
3. Wang, F, Yu, X, Qian, J, Cao, Y, Dong, S, Zhan, S, Lu, Z, Bast Jr, RC, Song, Q, Chen, Y, Zhang, Y, Zhou, J. A novel SIK2 inhibitor SIC-19 exhibits synthetic lethality with PARP inhibitors in ovarian cancer. Drug Resistance Updates 74, 2024. e-Pub 2024. PMID: 38518726.
4. Han CY, Lu KH, Corrigan G, Perez A, Kohring SD, Celestino J, Bedi D, Bedia E, Bevers T, Boruta D, Carlson M, Holman L, Leeds L, Mathews C, McCann G, Moore RG, Schlumbrecht M, Slomovitz B, Tobias D, Williams-Brown Y, Bevers MW, Liu J, Gornet TG, Handy BC, Lu Z, Bedia JS, Skates SJ, Bast RC Jr. Normal Risk Ovarian Screening Study: 21-Year Update. J Clin Oncol 42(10):1102-1109, 2024. e-Pub 2024. PMID: 38194613.
5. Bildik G, Gray JP, Mao W, Yang H, Ozyurt R, Orellana VR, De Wever O, Carey MS, Bast RC, Lu Z. DIRAS3 induces autophagy and enhances sensitivity to anti-autophagic therapy in KRAS-driven pancreatic and ovarian carcinomas. Autophagy 20(3):675-691, 2024. e-Pub 2024. PMID: 38169324.
6. Young Han C, Bedia JS, Yang WL, Hawley SJ, Bergan L, Hopper M, Celestino J, Guo J, Gornet TG, Soosaipillai A, Yang H, Doskocil SD, Lokshin AE, Handy BC, Diamandis EP, Moore RG, Lu KH, Lu Z, Anderson KS, Drescher CW, Skates SJ, Bast RC Jr. Autoantibodies, antigen-autoantibody complexes and antigens complement CA125 for early detection of ovarian cancer. Br J Cancer 130(5):861-868, 2024. e-Pub 2024. PMID: 38195887.
7. Liang X, Jung SY, Fong LW, Bildik G, Gray JP, Mao W, Zhang S, Millward SW, Gorfe AA, Zhou Y, Lu Z, Bast RC. Membrane anchoring of the DIRAS3 N-terminal extension permits tumor suppressor function. iScience 26(11):108151, 2023. e-Pub 2023. PMID: 37915607.
8. Im C, Sharafeldin N, Yuan Y, Wang Z, Sapkota Y, Lu Z, Spector LG, Howell RM, Arnold MA, Hudson MM, Ness KK, Robison LL, Bhatia S, Armstrong GT, Neglia JP, Yasui Y, Turcotte LM. Polygenic Risk and Chemotherapy-Related Subsequent Malignancies in Childhood Cancer Survivors: A Childhood Cancer Survivor Study and St Jude Lifetime Cohort Study Report. J Clin Oncol 41(27):4381-4393, 2023. e-Pub 2023. PMID: 37459583.
9. Edwards T, Arthur J, Joy M, Lu Z, Dibaj S, Bruera E, Zhukovsky D. Assessing risk for nonmedical opioid use among patients with cancer: Stability of the CAGE-AID questionnaire across clinical care settings. Palliat Support Care:1-5. e-Pub 2023. PMID: 37439217.
10. Arthur J, Pawate V, Lu Z, Yennurajalingam S, Azhar A, Reddy A, Epner D, Hui D, Tanco K, Delgado Guay MO, Vidal M, Chen M, Bruera E. Helpfulness of Question Prompt Sheet for Patient-Physician Communication Among Patients With Advanced Cancer: A Randomized Clinical Trial. JAMA Netw Open 6(5):e2311189, 2023. e-Pub 2023. PMID: 37129892.
11. Wu K, Yan M, Liu T, Wang Z, Duan Y, Xia Y, Ji G, Shen Y, Wang L, Li L, Zheng P, Dong B, Wu Q, Xiao L, Yang X, Shen H, Wen T, Zhang J, Yi J, Deng Y, Qian X, Ma L, Fang J, Zhou Q, Lu Z, Xu D. Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function. Nat Cell Biol 25(5):714-725, 2023. e-Pub 2023. PMID: 37156912.
12. Heung Y, Zhukovsky D, Hui D, Lu Z, Andersen C, Bruera E. Quality of End-of-Life Care during the COVID-19 Pandemic at a Comprehensive Cancer Center. Cancers (Basel) 15(8), 2023. e-Pub 2023. PMID: 37190130.
13. Zhukovsky DS, Heung Y, Enriquez P, Itzep N, Lu Z, Nortje N, Stanton P, Wong A, Bruera E. Just-in-Time Decision Making: Preliminary Findings of a Goals of Care Rapid Response Team. J Pain Symptom Manage 65(4):e337-e343, 2023. e-Pub 2023. PMID: 36496112.
14. Yennurajalingam S, Konopleva M, Carmack CL, Dinardo CD, Gaffney M, Michener HK, Lu Z, Stanton P, Ning J, Qiao W, Bruera E. Treatment of Cancer-related-Fatigue in Acute Hematological Malignancies: Results of a Feasibility Study of using Cognitive Behavioral Therapy. J Pain Symptom Manage 65(3):e189-e197, 2023. e-Pub 2023. PMID: 36384181.
15. Liu T, Wang Z, Ye L, Duan Y, Jiang H, He H, Xiao L, Wu Q, Xia Y, Yang M, Wu K, Yan M, Ji G, Shen Y, Wang L, Li L, Zheng P, Dong B, Shao F, Qian X, Yu R, Zhang Z, Lu Z, Xu D. Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth. Nat Cell Biol 25(2):273-284, 2023. e-Pub 2023. PMID: 36646788.
16. Zhao R, Ren S, Li C, Guo K, Lu Z, Tian L, He J, Zhang K, Cao Y, Liu S, Li D, Wang Z. Biomarkers for pancreatic cancer based on tissue and serum metabolomics analysis in a multicenter study. Cancer Med 12(4):5158-5171, 2023. e-Pub 2023. PMID: 36161527.
17. Timofeeva N, Ayres ML, Baran N, Santiago-O'Farrill JM, Bildik G, Lu Z, Konopleva M, Gandhi V. Preclinical investigations of the efficacy of the glutaminase inhibitor CB-839 alone and in combinations in chronic lymphocytic leukemia. Front Oncol 13:1161254, 2023. e-Pub 2023. PMID: 37228498.
18. Timofeeva N, Ayres ML, Baran N, Santiago-O'Farrill JM, Bildik G, Lu Z, Konopleva M, Gandhi V. Preclinical investigations of the efficacy of the glutaminase inhibitor CB-839 alone and in combinations in chronic lymphocytic leukemia. Front Oncol 13:1161254, 2023. e-Pub 2023. PMID: 37228498.
19. Yennurajalingam S, Azhar A, Lu Z, Rodriguez AJ, Arechiga AB, Guerra-Sanchez M, Stanton P, Andersen CR, Urbauer DL, Bruera E. Open-Label Placebo for the Treatment of Cancer-Related Fatigue in Patients with Advanced Cancer: A Randomized Controlled Trial. Oncologist 27(12):1081-1089, 2022. e-Pub 2022. PMID: 36106759.
20. Irajizad E, Han CY, Celestino J, Wu R, Murage E, Spencer R, Dennison JB, Vykoukal J, Long JP, Do KA, Drescher C, Lu K, Lu Z, Bast RC, Hanash S, Fahrmann JF. A blood-based metabolite panel for distinguishing ovarian cancer from benign pelvic masses. Clin Cancer Res 28(21):4669-4676, 2022. e-Pub 2022. PMID: 36037307.
21. Irajizad E, Han CY, Celestino J, Wu R, Murage E, Spencer R, Dennison JB, Vykoukal J, Long JP, Do KA, Drescher C, Lu K, Lu Z, Bast RC, Hanash S, Fahrmann JF. A blood-based metabolite panel for distinguishing ovarian cancer from benign pelvic masses. Clin Cancer Res 28(21):4669-4676, 2022. e-Pub 2022. PMID: 36037307.
22. Wang Z, Li M, Jiang H, Luo S, Shao F, Xia Y, Yang M, Ren X, Liu T, Yan M, Qian X, He H, Guo D, Duan Y, Wu K, Wang L, Ji G, Shen Y, Li L, Zheng P, Dong B, Fang J, Zheng M, Liang T, Li H, Yu R, Xu D, Lu Z. Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth. Nat Cell Biol 24(11):1655-1665, 2022. e-Pub 2022. PMID: 36266488.
23. Handley KF, Sims TT, Bateman NW, Glassman D, Foster KI, Lee S, Yao J, Yao H, Fellman BM, Liu J, Lu Z, Conrads KA, Hood BL, Barakat W, Zhao L, Zhang J, Westin SN, Celestino J, Rangel KM, Badal S, Pereira I, Ram PT, Maxwell GL, Eberlin LS, Futreal PA, Bast RC, Fleming ND, Conrads TP, Sood AK. Classification of High-Grade Serous Ovarian Cancer Using Tumor Morphologic Characteristics. JAMA Netw Open 5(10):e2236626, 2022. e-Pub 2022. PMID: 36239936.
24. Handley KF, Sims TT, Bateman NW, Glassman D, Foster KI, Lee S, Yao J, Yao H, Fellman BM, Liu J, Lu Z, Conrads KA, Hood BL, Barakat W, Zhao L, Zhang J, Westin SN, Celestino J, Rangel KM, Badal S, Pereira I, Ram PT, Maxwell GL, Eberlin LS, Futreal PA, Bast RC, Fleming ND, Conrads TP, Sood AK. Classification of High-Grade Serous Ovarian Cancer Using Tumor Morphologic Characteristics. JAMA Netw Open 5(10):e2236626, 2022. e-Pub 2022. PMID: 36239936.
25. Arthur JA, Edwards T, Lu Z, Tang M, Amaram-Davila J, Reddy A, Hui D, Yennurajalingam S, Anderson AE, Jennings K, Reddy S, Bruera E. Interdisciplinary intervention for the management of nonmedical opioid use among patients with cancer pain. Cancer 128(20):3718-3726, 2022. e-Pub 2022. PMID: 35997289.
26. Shao F, Gao Y, Wang W, He H, Xiao L, Geng X, Xia Y, Guo D, Fang J, He J, Lu Z. Silencing EGFR-upregulated expression of CD55 and CD59 activates the complement system and sensitizes lung cancer to checkpoint blockade. Nat Cancer 3(10):1192-1210, 2022. e-Pub 2022. PMID: 36271172.
27. Brown H, Chung M, Üffing A, Batistatou N, Tsang T, Doskocil S, Mao W, Willbold D, Bast RC, Lu Z, Weiergräber OH, Kritzer JA. Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy. J Am Chem Soc 144(32):14687-14697, 2022. e-Pub 2022. PMID: 35917476.
28. Shi X, Yu X, Wang J, Bian S, Li Q, Fu F, Zou X, Zhang L, Bast RC, Lu Z, Guo L, Chen Y, Zhou J. SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK. Mol Oncol 16(13):2558-2574, 2022. e-Pub 2022. PMID: 35278271.
29. Lu Z, Mao W, Yang H, Santiago-O'Farrill JM, Rask PJ, Mondal J, Chen H, Ivan C, Liu X, Liu CG, Xi Y, Masuda K, Carrami EM, Chen M, Tang Y, Pang L, Lakomy DS, Calin GA, Liang H, Ahmed AA, Vankayalapati H, Bast RC. SIK2 Inhibition Enhances PARP Inhibitor Activity Synergistically in Ovarian and Triple-Negative Breast Cancers. J Clin Invest 132(11), 2022. e-Pub 2022. PMID: 35642638.
30. Shangguan M, Jiang X, Lu Z, Zou W, Chen Y, Xu P, Pan Y, Hou L. Corrigendum to "A coumarin-based fluorescent probe for hypochlorite ion detection in environmental water samples and living cells" [Talanta 202 (2019) 303-307]. Talanta 234:122634, 2021. e-Pub 2021. PMID: 34364443.
31. Han CY, Patten DA, Kim SI, Lim JJ, Chan DW, Siu MKY, Han Y, Carmona E, Parks RJ, Lee C, Di LJ, Lu Z, Chan KKL, Ku JL, Macdonald EA, Vanderhyden BC, Mes-Masson AM, Ngan HYS, Cheung ANY, Song YS, Bast RC, Harper ME, Tsang BK. Nuclear HKII-P-p53 (Ser15) Interaction is a Prognostic Biomarker for Chemoresponsiveness and Glycolytic Regulation in Epithelial Ovarian Cancer. Cancers (Basel) 13(14), 2021. e-Pub 2021. PMID: 34298618.
32. Artibani M, Masuda K, Hu Z, Rauher PC, Mallett G, Wietek N, Morotti M, Chong K, KaramiNejadRanjbar M, Zois CE, Dhar S, El-Sahhar S, Campo L, Blagden SP, Damato S, Pathiraja PN, Nicum S, Gleeson F, Laios A, Alsaadi A, Santana Gonzalez L, Motohara T, Albukhari A, Lu Z, Bast RC, Harris AL, Ejsing CS, Klemm RW, Yau C, Sauka-Spengler T, Ahmed AA. Adipocyte-Like Signature in Ovarian Cancer Minimal Residual Disease Identifies Metabolic Vulnerabilities of Tumor-Initiating Cells. JCI Insight 6(11), 2021. e-Pub 2021. PMID: 33945502.
33. Fahrmann, JF, Irajizad, E, Kobayashi, M, Vykoukal, JV, Dennison, JB, Murage, EN, Wu, R, Long, JP, Do, K, Celestino, J, Lu, KH, Lu, Z, Bast Jr, RC, Hanash, S. A myc-driven plasma polyamine signature for early detection of ovarian cancer. Cancers 13(4):1-22, 2021. e-Pub 2021. PMID: 33671595.
34. Fan D, Yang H, Mao W, Rask PJ, Pang L, Xu C, Vankayalapat H, Ahmed AA, Bast RC, Lu Z. A Novel Salt Inducible Kinase 2 Inhibitor, ARN-3261, Sensitizes Ovarian Cancer Cell Lines and Xenografts to Carboplatin. Cancers (Basel) 13(3):1-15, 2021. e-Pub 2021. PMID: 33503955.
35. Gray JP, Uddin MN, Chaudhari R, Sutton MN, Yang H, Rask P, Locke H, Engel BJ, Batistatou N, Wang J, Grindel BJ, Bhattacharya P, Gammon ST, Zhang S, Piwnica-Worms D, Kritzer JA, Lu Z, Bast RC, Millward SW. Directed Evolution of Cyclic Peptides for Inhibition of Autophagy. Chem Sci 12(10):3526-3543, 2021. e-Pub 2021. PMID: 34163626.
36. Bast RC, Han CY, Lu Z, Lu KH. Next Steps in the Early Detection of Ovarian Cancer. Commun Med (Lond) 1, 2021. e-Pub 2021. PMID: 34676377.
37. Bast RC, Lu Z, Han CY, Lu KH, Anderson KS, Drescher CW, Skates SJ. Biomarkers and Strategies for Early Detection of Ovarian Cancer. Cancer Epidemiol Biomarkers Prev 29(12):2504-2512, 2020. e-Pub 2020. PMID: 33051337.
38. Blessing AM, Santiago-O'Farrill JM, Mao W, Pang L, Ning J, Pak D, Bollu LR, Rask P, Iles L, Yang H, Tran S, Elmir E, Bartholomeusz G, Langley R, Lu Z, Bast RC. Elimination of dormant, autophagic ovarian cancer cells and xenografts through enhanced sensitivity to anaplastic lymphoma kinase inhibition. Cancer 126(15):3579-3592, 2020. e-Pub 2020. PMID: 32484926.
39. Blessing A, Santiago-O’Farrill J, W, Pang L, Ning J, Pak D, Iles L, Rask P, Iles L, Tran S, Elmir E, Bartholomeusz G, Langley R, Lu Z, Bast R. Elimination of dormant, autophagic ovarian cancer cells and xenografts through enhanced sensitivity to ALK inhibition 15(126):3579-3592, 2020. e-Pub 2020.
40. Kobayashi M, Katayama H, Irajizad E, Vykoukal JV, Fahrmann JF, Kundnani DL, Yu CY, Cai Y, Hsiao FC, Yang WL, Lu Z, Celestino J, Long JP, Do KA, Lu KH, Ladd JJ, Urban N, Bast RC, Hanash SM. Proteome Profiling Uncovers an Autoimmune Response Signature That Reflects Ovarian Cancer Pathogenesis. Cancers (Basel) 12(2), 2020. e-Pub 2020. PMID: 32092936.
41. Santiago-O'Farrill JM, Weroha SJ, Hou X, Oberg AL, Heinzen EP, Maurer MJ, Pang L, Rask P, Amaravadi RK, Becker SE, Romero I, Rubio MJ, Matias-Guiu X, Santacana M, Llombart-Cussac A, Poveda A, Lu Z, Bast RC. Poly(Adenosine Diphosphate Ribose) Polymerase Inhibitors Induce Autophagy-Mediated Drug Resistance in Ovarian Cancer Cells, Xenografts, and Patient-Derived Xenograft Models. Cancer 126(4):894-907, 2020. e-Pub 2020. PMID: 31714594.
42. Yang WL, Lu Z, Guo J, Fellman BM, Ning J, Lu KH, Menon U, Kobayashi M, Hanash SM, Celestino J, Skates SJ, Bast RC. Human Epididymis Protein 4 Antigen-Autoantibody Complexes Complement Cancer Antigen 125 for Detecting Early-Stage Ovarian Cancer. Cancer 126(4):725-736, 2020. e-Pub 2020. PMID: 31714597.
43. Sutton MN, Lu Z, Li YC, Zhou Y, Huang T, Reger AS, Hurwitz AM, Palzkill T, Logsdon C, Liang X, Gray JW, Nan X, Hancock J, Wahl GM, Bast RC. DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to Ras and Disrupting Ras Clusters. Cell Rep 29(11):3448-3459.e6, 2019. e-Pub 2019. PMID: 31825828.
44. Guo J, Lu Z, Bast RC. Reply to Comment on "Osteopontin, Macrophage Migration Inhibitory Factor and Anti-Interleukin-8 Autoantibodies Complement CA125 for Detection of Early Stage Ovarian Cancer" Cancers 2019, 11, 596: Markers for Early Detection of Ovarian Cancer. Cancers (Basel) 11(9), 2019. e-Pub 2019. PMID: 31540545.
45. Yang H, Shu Z, Jiang Y, Mao W, Pang L, Redwood A, Jeter-Jones SL, Jennings NB, Ornelas A, Zhou J, Rodriguez-Aguayo C, Bartholomeusz G, Iles LR, Zacharias NM, Millward SW, Lopez-Berestein G, Le XF, Ahmed AA, Piwnica-Worms H, Sood AK, Bast RC, Lu Z. 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers. Clin Cancer Res 7(18):5702-5716, 2019. e-Pub 2019. PMID: 31391192.
46. Bast RC, Matulonis UA, Sood AK, Ahmed AA, Amobi AE, Balkwill FR, Wielgos-Bonvallet M, Bowtell DDL, Brenton JD, Brugge JS, Coleman RL, Draetta GF, Doberstein K, Drapkin RI, Eckert MA, Edwards RP, Elias KM, Ennis D, Futreal A, Gershenson DM, Greenberg RA, Huntsman DG, Ji JXY, Kohn EC, Iavarone C, Lengyel ER, Levine DA, Lord CJ, Lu Z, Mills GB, Modugno F, Nelson BH, Odunsi K, Pilsworth JA, Rottapel RK, Powell DJ, Shen L, Shih IM, Spriggs DR, Walton J, Zhang K, Zhang R, Zou L. Critical Questions in Ovarian Cancer Research and Treatment: Report of an American Association for Cancer Research Special Conference. Cancer 125(12):1963-1972, 2019. e-Pub 2019. PMID: 30835824.
47. Sutton MN, Huang GY, Zhou J, Mao W, Langley R, Lu Z, Bast RC. Amino Acid Deprivation-Induced Autophagy Requires Upregulation of DIRAS3 through Reduction of E2F1 and E2F4 Transcriptional Repression. Cancers (Basel) 11(5), 2019. e-Pub 2019. PMID: 31052266.
48. Guo J, Yang WL, Pak D, Celestino J, Lu KH, Ning J, Lokshin AE, Cheng Z, Lu Z, Bast RC. Osteopontin, Macrophage Migration Inhibitory Factor and Anti-Interleukin-8 Autoantibodies Complement CA125 for Detection of Early Stage Ovarian Cancer. Cancers (Basel) 11(5), 2019. e-Pub 2019. PMID: 31035430.
49. Sutton MN, Huang GY, Liang X, Sharma R, Reger AS, Mao W, Pang L, Rask PJ, Lee K, Gray JP, Hurwitz AM, Palzkill T, Millward SW, Kim C, Lu Z, Bast RC. DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1. Cancers (Basel) 11(4), 2019. e-Pub 2019. PMID: 31003488.
50. Mao W, Peters HL, Sutton MN, Orozco AF, Pang L, Yang H, Lu Z, Bast RC. The role of vascular endothelial growth factor, interleukin 8, and insulinlike growth factor in sustaining autophagic DIRAS3-induced dormant ovarian cancer xenografts. Cancer 125(8):1267-1280, 2019. e-Pub 2019. PMID: 30620384.
51. Yang H, Mao W, Rodriguez-Aguayo C, Mangala LS, Bartholomeusz G, Iles LR, Jennings NB, Ahmed AA, Sood AK, Lopez-Berestein G, Lu Z, Bast RC. Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability. Clin Cancer Res 24(20):5072-5084, 2018. e-Pub 2018. PMID: 30084832.
52. Sutton MN, Yang H, Huang GY, Fu C, Pontikos M, Wang Y, Mao W, Pang L, Yang M, Liu J, Parker-Thornburg J, Lu Z, Bast RC. RAS-related GTPases DIRAS1 and DIRAS2 induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells. Autophagy 14(4):1-47, 2018. e-Pub 2018. PMID: 29368982.
53. Yang WL, Gentry-Maharaj A, Simmons A, Ryan A, Fourkala EO, Lu Z, Baggerly KA, Zhao Y, Lu KH, Bowtell D, Jacobs I, Skates SJ, He WW, Menon U, Bast RC, Group AS. Elevation of TP53 Autoantibody Before CA125 in Preclinical Invasive Epithelial Ovarian Cancer. Clin Cancer Res 23(19):5912-5922, 2017. e-Pub 2017. PMID: 28637689.
54. Yang WL, Lu Z, Bast RC. The Role of Biomarkers in the Management of Epithelial Ovarian Cancer. Expert Rev Mol Diagn 17(6):577-591, 2017. e-Pub 2017. PMID: 28468520.
55. Zhou J, Alfraidi A, Zhang S, Santiago-O'Farrill JM, Yerramreddy Reddy VK, Alsaadi A, Ahmed AA, Yang H, Liu J, Mao W, Wang Y, Takemori H, Vankayalapati H, Lu Z, Bast RC. A novel compound ARN-3236 inhibits Salt Inducible Kinase 2 and sensitizes ovarian cancer cell lines and xenografts to paclitaxel. Clin Cancer Res 23(8):1945-1954, 2017. e-Pub 2017. PMID: 27678456.
56. Ornelas A, McCullough CR, Lu Z, Zacharias NM, Kelderhouse LE, Gray J, Yang H, Engel BJ, Wang Y, Mao W, Sutton MN, Bhattacharya PK, Bast RC, Millward SW. Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models. BMC Cancer 16(1):824, 2016. e-Pub 2016. PMID: 27784287.
57. Simmons AR, Clarke CH, Badgwell DB, Lu Z, Sokoll LJ, Lu KH, Zhang Z, Bast RC, Skates SJ. Validation of a Biomarker Panel and Longitudinal Biomarker Performance for Early Detection of Ovarian Cancer. Int J Gynecol Cancer 26(6):1070-7, 2016. e-Pub 2016. PMID: 27206285.
58. Santiago-O’Farrill JM, Lu Z, Bast RC. Autophagy and Cancer Chemotherapy: Inhibition or Enhancement?. Single Cell Biol 5(145), 2016. e-Pub 2016.
59. Ejaz A, Mitterberger MC, Lu Z, Mattesich M, Zwierzina ME, Hörl S, Kaiser A, Viertler HP, Rostek U, Meryk A, Khalid S, Pierer G, Bast RC, Zwerschke W. Weight Loss Upregulates the Small GTPase DIRAS3 in Human White Adipose Progenitor Cells, Which Negatively Regulates Adipogenesis and Activates Autophagy via Akt-mTOR Inhibition. EBioMedicine 6:149-61, 2016. e-Pub 2016. PMID: 27211557.
60. Morgado M, Sutton MN, Simmons M, Warren CR, Lu Z, Constantinou PE, Liu J, Francis LL, Conlan RS, Bast RC, Carson DD. Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB. Oncotarget 7(12):14871-84, 2016. e-Pub 2016. PMID: 26918940.
61. Yang H, Das P, Yu Y, Mao W, Wang Y, Baggerly K, Wang Y, Marquez RT, Bedi A, Liu J, Fishman D, Lu Z, Bast RC. NDN is an Imprinted Tumor Suppressor Gene that is Downregulated in Ovarian Cancers through Genetic and Epigenetic Mechanisms. Oncotarget 7(3):3018-32, 2016. e-Pub 2016. PMID: 26689988.
62. Washington MN, Suh G, Orozco AF, Sutton MN, Yang H, Wang Y, Mao W, Millward S, Ornelas A, Atkinson, N, Liao WS, Jr BR, Lu Z. ARHI (DIRAS3)-Mediated Autophagy Associated Cell Death Enhances Chemosensitivity to Cisplatin in Ovarian Cancer Cell Lines and Xenografts. Cell Death and Disease 6, 2015. e-Pub 2015.
63. Zhang S, Lu Z, Mao W, Ahmed AA, Yang H, Zhou J, Jennings N, Rodriguez-Aguayo C, Lopez-Berestein G, Miranda R, Qiao W, Baladandayuthapani V, Li Z, Sood AK, Liu J, Le XF, Bast RC. CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis. PLoS One 10(7):e0131833, 2015. e-Pub 2015. PMID: 26146988.
64. Zhang S, Lu Z, Unruh AK, Ivan C, Baggerly KA, Calin GA, Li Z, Bast RC, Le XF. Clinically Relevant microRNAs in Ovarian Cancer. Mol Cancer Res. e-Pub 2014. PMID: 25304686.
65. Lu Z, Yang H, Sutton MN, Yang M, Clarke CH, Liao WS, Bast RC. ARHI (DIRAS3) Induces Autophagy in Ovarian Cancer Cells by Downregulating the Epidermal Growth Factor Receptor, Inhibiting PI3K and Ras/MAP Signaling and Activating the FOXo3a-Mediated Induction of Rab7. Cell Death Differ 21(8):1275-89, 2014. e-Pub 2014. PMID: 24769729.
66. Lu Z, Baquero MT, Yang H, Yang M, Reger AS, Kim C, Levine DA, Clarke CH, Liao WS, Bast RC. DIRAS3 Regulates the Autophagosome Initiation Complex in Dormant Ovarian Cancer Cells. Autophagy 10(6):1071-92, 2014. e-Pub 2014. PMID: 24879154.
67. Lyu T, Jia N, Wang J, Yan X, Yu Y, Lu Z, Bast RC, Hua K, Feng W. Expression and Epigenetic Regulation of Angiogenesis-Related Factors During Dormancy and Recurrent Growth of Ovarian Carcinoma. Epigenetics 8(12):1330-46, 2013. e-Pub 2013. PMID: 24135786.
68. Lu Z, Bast RC. The Tumor Suppressor Gene ARHI (DIRAS3) Inhibits Ovarian Cancer Cell Migration through Multiple Mechanisms. Cell Adh Migr 7(2):232-6, 2013. e-Pub 2013. PMID: 23357870.
69. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Cho. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy. Autophagy 8(4):445-544, 2012. e-Pub 2012. PMID: 22966490.
70. Badgwell DB, Lu Z, Le K, Gao F, Yang M, Suh GK, Bao JJ, Das P, Andreeff M, Chen W, Yu Y, Ahmed AA, S-L Liao W, Bast RC. The Tumor-Suppressor Gene ARHI (DIRAS3) Suppresses Ovarian Cancer Cell Migration through Inhibition of the Stat3 and FAK/Rho Signaling Pathways. Oncogene 31(1):68-79, 2012. e-Pub 2012. PMID: 21643014.
71. Auzenne EJ, Klostergaard J, Mandal PK, Liao WS, Lu Z, Gao F, Bast RC, Robertson FM, McMurray JS. A Phosphopeptide Mimetic Prodrug Targeting the SH2 Domain of Stat3 Inhibits Tumor Growth and Angiogenesis. J Exp Ther Oncol 10(2):155-62, 2012. e-Pub 2012. PMID: 23350355.
72. Chen MY, Liao WS, Lu Z, Bornmann WG, Hennessey V, Washington MN, Rosner GL, Yu Y, Ahmed AA, Bast RC. Decitabine and Suberoylanilide Hydroxamic Acid (SAHA) Inhibit Growth of Ovarian Cancer Cell Lines and Xenografts while Inducing Expression of Imprinted Tumor Suppressor Genes, Apoptosis, G2/M Arrest, and Autophagy. Cancer 117(19):4424-38, 2011. e-Pub 2011. PMID: 21491416.
73. Ahmed AA, Wang X, Lu Z, Goldsmith J, Le XF, Grandjean G, Bartholomeusz G, Broom B, Bast RC. Modulating Microtubule Stability Enhances the Cytotoxic Response of Cancer Cells to Paclitaxel. Cancer Res 71(17):5806-17, 2011. e-Pub 2011. PMID: 21775522.
74. Mandal PK, Gao F, Lu Z, Ren Z, Ramesh R, Birtwistle JS, Kaluarachchi KK, Chen X, Bast RC, Liao WS, McMurray JS. Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3. J Med Chem 54(10):3549-63, 2011. e-Pub 2011. PMID: 21486047.
75. Zou CF, Jia L, Jin H, Yao M, Zhao N, Huan J, Lu Z, Bast RC, Feng Y, Yu Y. Re-expression of ARHI (DIRAS3) Induces Autophagy in Breast Cancer Cells and Enhances the Inhibitory Effect of Paclitaxel. BMC Cancer 11:22, 2011. e-Pub 2011. PMID: 21244707.
76. Le XF, Mao W, Lu Z, Carter BZ, Bast RC. Dasatinib Induces Autophagic Cell Death in Human Ovarian Cancer. Cancer 116(21):4980-90, 2010. e-Pub 2010. PMID: 20629079.
77. Ahmed AA, Lu Z, Jennings NB, Etemadmoghadam D, Capalbo L, Jacamo RO, Barbosa-Morais N, Le XF, Study Group AOC, Vivas-Mejia P, Lopez-Berestein G, Grandjean G, Bartholomeusz G, Liao W, Andreeff M, Bowtell D, Glover DM, Sood AK, Bast RC. SIK2 is a Centrosome Kinase Required for Bipolar Mitotic Spindle Formation that Provides a Potential Target for Therapy in Ovarian Cancer. Cancer Cell 18(2):109-21, 2010. e-Pub 2010. PMID: 20708153.
78. Huang S, Chang IS, Lin W, Ye W, Luo RZ, Lu Z, Lu Y, Zhang K, Liao WS, Tao T, Bast RC, Chen X, Yu Y. ARHI (DIRAS3), an Imprinted Tumor Suppressor Gene, Binds to Importins and Blocks Nuclear Import of Cargo Proteins. Biosci Rep 30(3):159-68, 2010. e-Pub 2010. PMID: 19435463.
79. Xie X, Hsu JL, Choi MG, Xia W, Yamaguchi H, Chen CT, Trinh BQ, Lu Z, Ueno NT, Wolf JK, Bast RC, Hung MC. A Novel hTERT Promoter-Driven E1A Therapeutic for Ovarian Cancer. Mol Cancer Ther 8(8):2375-82, 2009. e-Pub 2009. PMID: 19671744.
80. Cheon DJ, Wang Y, Deng JM, Lu Z, Xiao L, Chen CM, Bast RC, Behringer RR. CA125/MUC16 is Dispensable for Mouse Development and Reproduction. PLoS One 4(3):e4675, 2009. e-Pub 2009. PMID: 19262696.
81. Lu Z, Luo RZ, Lu Y, Zhang X, Yu Q, Khare S, Kondo S, Kondo Y, Yu Y, Mills GB, Liao WS, Bast RC. The Tumor Suppressor Gene ARHI Regulates Autophagy and Tumor Dormancy in Human Ovarian Cancer Cells. J Clin Invest 118(12):3917-29, 2008. e-Pub 2008. PMID: 19033662.
82. Wang Y, Cheon DJ, Lu Z, Cunningham SL, Chen CM, Luo RZ, Xing D, Orsulic S, Bast RC, Behringer RR. MUC16 Expression During Embryogenesis, in Adult Tissues, and Ovarian Cancer in the Mouse. Differentiation 76(10):1081-92, 2008. e-Pub 2008. PMID: 18637025.
83. Moore RG, Brown AK, Miller MC, Badgwell D, Lu Z, Allard WJ, Granai CO, Bast RC, Lu K. Utility of a Novel Serum Tumor Biomarker HE4 in Patients with Endometrioid Adenocarcinoma of the Uterus. Gynecol Oncol 110(2):196-201, 2008. e-Pub 2008. PMID: 18495222.
84. Feng W, Marquez RT, Lu Z, Liu J, Lu KH, Issa JP, Fishman DM, Yu Y, Bast RC. Imprinted Tumor Suppressor Genes ARHI and PEG3 are the Most Frequently Down-Regulated in Human Ovarian Cancers by Loss of Heterozygosity and Promoter Methylation. Cancer 112(7):1489-502, 2008. e-Pub 2008. PMID: 18286529.
85. Badgwell D, Lu Z, Cole L, Fritsche H, Atkinson EN, Somers E, Allard J, Moore RG, Lu KH, Bast RC. Urinary Mesothelin Provides Greater Sensitivity for Early Stage Ovarian Cancer than Serum Mesothelin, Urinary hCG Free Beta Subunit and Urinary hCG Beta Core Fragment. Gynecol Oncol 106(3):490-7, 2007. e-Pub 2007. PMID: 17532030.
86. Feng W, Lu Z, Luo RZ, Zhang X, Seto E, Liao WS, Yu Y. Multiple Histone Deacetylases Repress Tumor Suppressor Gene ARHI in Breast Cancer. Int J Cancer 120(8):1664-8, 2007. e-Pub 2007. PMID: 17230502.
87. Le XF, Bedrosian I, Mao W, Murray M, Lu Z, Keyomarsi K, Lee MH, Zhao J, Bast RC. Anti-HER2 Antibody Trastuzumab Inhibits CDK2-Mediated NPAT and Histone H4 Expression via the PI3K Pathway. Cell Cycle 5(15):1654-61, 2006. e-Pub 2006. PMID: 16861913.
88. Lu Z, Luo RZ, Peng H, Rosen DG, Atkinson EN, Warneke C, Huang M, Nishmoto A, Liu J, Liao WS, Yu Y, Bast RC. Transcriptional and Posttranscriptional Down-Regulation of the Imprinted Tumor Suppressor Gene ARHI (DRAS3) in Ovarian Cancer. Clin Cancer Res 12(8):2404-13, 2006. e-Pub 2006. PMID: 16638845.
89. Lu Z, Luo RZ, Peng H, Huang M, Nishmoto A, Hunt KK, Helin K, Liao WS, Yu Y. E2F-HDAC Complexes Negatively Regulate the Tumor Suppressor Gene ARHI in Breast Cancer. Oncogene 25(2):230-9, 2006. e-Pub 2006. PMID: 16158053.
90. Yu Y, Luo R, Lu Z, Wei Feng W, Badgwell D, Issa JP, Rosen DG, Liu J, Bast RC. Biochemistry and Biology of ARHI (DIRAS3), an Imprinted Tumor Suppressor Gene whose Expression is Lost in Ovarian and Breast Cancers. Methods Enzymol 407:455-68, 2006. e-Pub 2006. PMID: 16757345.
91. Nishimoto A, Yu Y, Lu Z, Mao X, Ren Z, Watowich SS, Mills GB, Liao WS, Chen X, Bast RC, Luo RZ. A Ras Homologue Member I Directly Inhibits Signal Transducers and Activators of Transcription 3 Translocation and Activity in Human Breast and Ovarian Cancer Cells. Cancer Res 65(15):6701-10, 2005. e-Pub 2005. PMID: 16061651.
92. Jr BR, Badgwell D, Lu Z, Marquez R, Rosen D, Liu J, Baggerly K, Atkinson EN, Skate S, Zhang Z, Lokshin A, Menon U, Jacobs I, Lu K. New Tumor Marker: CA125 and Beyond. Int J Gynecol Cancer(15 Suppl 3):274-281, 2005. e-Pub 2005.
93. Wang L, Hoque A, Luo RZ, Yuan J, Lu Z, Nishimoto A, Liu J, Sahin AA, Lippman SM, Bast RC, Yu Y. Loss of the Expression of the Tumor Suppressor Gene ARHI is Associated with Progression of Breast Cancer. Clin Cancer Res 9(10 Pt 1):3660-6, 2003. e-Pub 2003. PMID: 14506155.
94. K-T C, Lu Z, Chow MW. Mechanism of Inhibition of Tannic Acid and Related Compounds on Growth of Intestinal Bacteria. Food and Chemical Toxicology(36):1053-1060, 1998. e-Pub 1998.
95. Kong Q, Lu Z. Observation on Cellular Kinetics in Experimental Mouse Colon Carcinoma. Acta Academic Medicine Suzhou:166-168, 1992. e-Pub 1992.
96. Lu Z, Zhang P, Mao D. Experimental Studies for Murine Colon Cancer Induced by GMM. Acta Academic Medicine Suzhou(11):24-29, 1991. e-Pub 1991.

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1. Yennurajalingam S, Lu Z, Rozman De Moraes A, Tull NN, Kubiak MJ, Geng Y, Andersen CR, Bruera E Meta-Analysis of Pharmacological, Nutraceutical and Phytopharmaceutical Interventions for the Treatment of Cancer Related Fatigue. Cancers (Basel) 15(1), 2022. PMID: 36612088.
2. Liang W, Cai K, Cao Q, Chen C, Chen H, Chen J, Chen KN, Chen Q, Chu T, Dong Y, Fan J, Fang W, Fu J, Fu X, Gao S, Ge D, Geng G, Geng Q, He J, Hu J, Hu J, Hu WD, Jiang F, Jiang T, Jiao W, Li HC, Li Q, Li S, Li S, Li X, Liao YD, Liu C, Liu H, Liu Y, Lu Z, Luo Q, Ma H, Pan X, Qiao G, Ren S, Shen W, Song Y, Sun D, Wang G, Wang J, Wang M, Wang Q, Wang WX, Wei L, Wu M, Wu N, Xia H, Xu SD, Yang F, Yang K, Yang Y, Yu F, Yu ZT, Yue DS, Zhang L, Zhang W, Zhang Z, Zhao G, Zhao J, Zhao X, Zhou C, Zhou Q, Zhu K, Zhu Y, Hida T, Dempke WCM, Rossi A, de Perrot M, Ramirez RA, Provencio M, Lee JM, Passaro A, Spaggiari L, Spicer J, Girard N, Forde PM, Mok TSK, Cascone T, He J International expert consensus on immunotherapy for early-stage non-small cell lung cancer. Transl Lung Cancer Res 11(9):1742-1762, 2022. PMID: 36248334.
3. Bildik G, Liang X, Sutton MN, Bast RC, Lu Z DIRAS3: An Imprinted Tumor Suppressor Gene that Regulates RAS and PI3K-driven Cancer Growth, Motility, Autophagy, and Tumor Dormancy. Mol Cancer Ther 21(1):25-37, 2022. PMID: 34667114.
4. Bast RC, Brewer M, Zou C, Hernandez MA, Daley M, Ozols R, Lu K, Lu Z, Badgwell D, Mills GB, Skates S, Zhang Z, Chan D, Lokshin A, Yu Y Prevention and early Detection of Ovarian Cancer: Mission Impossible?. Recent Results Cancer Res 174:91-100, 2007. PMID: 17302189.

Abstracts

1. Liang X, Lee K, Jung SY, Bildik G, Mao W, Gray JP, Millward SW, Lu Z, Bast RC. Structural and Biochemical Properties of DIRAS3 N-Terminal Extension that Permit its Function as a Tumor Suppressor of Oncogenic K-RAS. Cancer Research Abstract 83 10(1158):1538-7445, 2021. e-Pub 2021.
2. Bildik G, Gray JP, Mao W, Bast RC, Lu Z. DIRAS3 Induces Autophagy and Enhances Sensitivity to Anti-Autophagic Therapy in KRAS-Driven Pancreatic and Ovarian Carcinomas. Cancer Research Abstract 1999 10(1158):1538-7445, 2021. e-Pub 2021.
3. Lu Z, Mso W, Santiago-O'Farrill JM, Yang H, Pang L, Ahmed AA, Vankayalapati H, Bast Jr RC. Novel SIK2 Inhibitors Sensitize Ovarian and Breast Cancer to PARP Inhibitors. Proc Amer Assoc Cancer Res, 2020. e-Pub 2020.
4. Santiago-O'Farrill JM, Blessing AM, Becker SE, Lu Z, Bast RC. Crizotinib improves the therapeutic efficacy of olaparib in ovarian cancer. Proc Amer Assoc Cancer Res, 2020. e-Pub 2020.
5. Luan B, Zhao H, Jr BR, Lu Z, Yu Y. Corilagin Could Help to Overcome PARP Inhibitor Resistance by Inhibiting ERK Signaling Pathways. Proc Amer Assoc Cancer Res, 2019. e-Pub 2019.
6. Guo J, W-L Y, Celestino J, Lu K, Lu Z, Jr BR. Macrophage Inhibitory Factor (MIF), Osteopontin (OPN) and Anti- Interleukin-8 (IL-8) Autoantibodies (AAb) complement CA125 for Detection of Early Stage Ovarian Cancer. Proc Amer Assoc Cancer Res, 2019. e-Pub 2019.
7. Blessing AM, Mao W, Pang L, Rask P, Lu Z, Bast RC. Autophagic Ovarian Cancer Cells Exhibit Substantially Enhanced Sensitivity to ALK Inhibition. Proc Amer Assoc Cancer Res, 2019. e-Pub 2019.
8. Santiago-O'Farrill JM, Werhoa SJ, Hou X, Pang L, Rask P, Lu Z, Bast RC. PARP Inhibitor-induced Autophagy provides an Adaptive Mechanism of Drug Resistance in preclinical models of ovarian cancer. Proc Amer Assoc Cancer Res, 2019. e-Pub 2019.
9. Lu Z, Mao W, Pang L, Santiago-O'Farrill JM, Yang H, Ahmed A, Vankayalapati H, C Bast AR. SIK2 Inhibitors Regulate DNA Repair Pathway and Sensitize Ovarian Cancer to PARP1 Inhibitors. Cancer Research 78(13), 2018. e-Pub 2018.
10. Sutton MN, Huang GY, Zhou J, Lu Z, C Bast AR. DIRAS3 (ARHI) is required for amino acid-mediated autophagy and nutrient deprivation in dormant ovarian cancers. Cancer Research 78(13), 2018. e-Pub 2018.
11. Lu Z. Silencing PFKFB2 Enhances Paclitaxel Sensitivity by Modulating Metabolism of Ovarian and Breast Cancer Cells and Xenografts with WT p53. Proc Amer Assoc Cancer Res, 2017. e-Pub 2017.
12. Mathieu K, Lu Z, Yang H, Pang L, Kulp A, Hazle J, Bast R. Feasibility of Magnetic Relaxometry for Early Ovarian Cancer Detection: Preliminary Evaluation of Sensitivity and Specificity in Culture and in Mice. Proc Amer Assoc Cancer Res, 2017. e-Pub 2017.
13. Thrower SL, Mathieu K, Stefan W, Aburto R, Lu Z, Bast RC, Sovizi J, Fuentes D, Hazle JD. Volumetric Reconstruction of Targeted Nanoparticles for Superparamagnetic Relaxometry. Proc Amer Assoc Cancer Res, 2017. e-Pub 2017.
14. Blessing AM, Wang Y, Mao W, Pang L, Lu Z, Bast RC. Autophagic Ovarian Cancer Cells Exhibit Substantially Enhanced Sensitivity to Crizotinib. Proc Amer Assoc Cancer Res, 2017. e-Pub 2017.
15. Santiago-O'Farrill JM, Essien S, Figueroa M, Pang L, Amaravadi R, Lu Z, Bast RC. Autophagy Protects Ovarian Cancer Cells from Olaparib-Induced Toxicity. Proc Amer Assoc Cancer Res, 2017. e-Pub 2017.
16. Sutton MN, Lu Z, Y-C L, Zhou Y, Huang T, Reger AS, Hurwitz AM, Palzkill T, Logsodn C, Gray JW, Nan X, Hancock J, Wahl GM, Jr BR. DIRAS3 (ARHI) blocks Ras/MAPK signaling by binding directly to Ras and disrupting Ras clusters. The Second Ras Initiative Symposium, 2017. e-Pub 2017.
17. Yang H, Wang X, Ahmed A, Iles L, Bartholomeusz G, Lu Z, Bast Jr RC. Combinations of Kinase siRNAs Potentiates Paclitaxel Sensitivity in Ovarian Cancer. Proc Amer Assoc Cancer Res 76(14), 2016. e-Pub 2016.
18. Zhou J, Alfraidi A, Zhang S, Santiago-O'Farrill J, Yerramreddy V, Alsaadid A, Ahmed AA, Yang H, Liu J, Mao W, Takemori H, Wang Y, Vankayalapati H, Lu Z, Bast RC. A novel compound ARN-3236 inhibits Salt Inducible Kinase 2 and sensitizes ovarian cancer cell lines and xenografts to paclitaxel. Proc Amer Assoc Cancer Res 76(14), 2016. e-Pub 2016.
19. Lu Z, Orozco A, Mao W, Wang Y, Sutton MN, Yang H, Levine DA, Bast Jr RC. IL-8, VEGF and IGF-1 Play the Important Role in ARHI Mediated-Tumor Dormancy in Ovarian Cancer. Proc Amer Assoc Cancer Res 76(14), 2016. e-Pub 2016.
20. Sutton MN, Lu Z, Yang H, Huang G, Wang Y, Mao W, Bast RC. DIRAS1 and DIRAS2 are novel ovarian cancer tumor suppressors that regulate cell growth, motility and autophagy. Proc Amer Assoc Cancer Res 76(14), 2016. e-Pub 2016.
21. Sutton MN, Lu Z, Li Y, Reger A, Hurwitz A, Palzkill T, Wahl G, Bast RC. DIRAS3 (ARHI) Downregulates Ras/MAPK Signaling via Interaction and Inhibition of Ras Dimers. Journal of Clinical and Translational Science(#THP97), 2016. e-Pub 2016.
22. Lu Z, Mao W, Wang Y, Levine DA, Jr BR. ARHI plays a critical role in ovarian cancer tumor dormancy by inhibition of angiogenesis switch. Proc Amer Assoc Cancer Res, 2015. e-Pub 2015.
23. Yang WL, Simmons A, Lu Z, Baggerly K, Lu K. TP53 Autoantibody Can Detect CA125 Screen Negative Ovarian Cancer Cases and Can be Elevated Prior to CA125 in Preclinical Ovarian Cancer. Proc Amer Assoc Cancer Res, 2015. e-Pub 2015.
24. Morgado M, Sutton MN, Simmons M, Liu J, Lu Z, Papadppoulos PE, Bast RC, Jr, Carson DD. MC16/CA!25, TNFα and IFN-γ are Co-Expressed in Malignant Gynecologic Neoplasms. Proc Amer Assoc Cancer Res, 2015. e-Pub 2015.
25. Lu Z, Orozco AF, Sutton MN, Wang Y, Mao W, Bast RC. IL8, VEGF and IGF-1 Rescue Ovarian Cancer Cells Undergoing ARHI-Mediated-Autophagic Cell Death. Proc Amer Assoc Cancer Res, 2015. e-Pub 2015.
26. Yang H, Das P, Yu Y, Mao W, Marquez R T, Lu Z, Bast RC, Jr. NDN, an Imprinted Tumor Suppressor Gene Inhibits Ovarian Cancer Cell Motility in Ovarian Cancer by Deactivating FAK and RhoA. Proc Amer Assoc Cancer Res, 2015. e-Pub 2015.
27. Alfredi A, Zhang S, Mao W, Wang Y, Takemori H, Bast, Jr RC, Lu Z, Vankayalapati H. Highly Potent and Orally Available SIK2 Inhibitors Block Growth of Human Ovarian Cancer Cells in Culture and Xenografts. Proc Amer Assoc Cancer Res, 2014. e-Pub 2014.
28. Sutton M, Lu Z, Gomez S, Fu C, Jr BR. ARHI (DIRAS3) Downregulates Ras-MAPK Signaling and Inhibits Transformation of NIH3T3 Cells through Direct Interaction with GTP-Bound Ras. Proc Amer Assoc Cancer Res, 2014. e-Pub 2014.
29. Yang H, Das P, Yu Y, Baggerly K, Wang Y, Mao W, Marquez RT, Lu Z, Liu J, Jr BR. NDN, an Imprinted Tumor Suppressor Gene, Inhibits Ovarian Cancer Cell Growth and Motility and is Downregulated by Genetic and Epigenetic Mechanisms. Proc Amer Assoc Cancer Res, 2014. e-Pub 2014.
30. Jr BR, Sutton MN, Gomez S, Fu C, Pontrakis M, Lu Z. The role of the Imprinted Tumor Suppressor Gene DIRAS3 (ARHI) in Regulating Ovarian Cancer Cell Growth, Motility, Autophagy and Tumor Dormancy. 1st Annual Meeting of the International Ovarian Cancer Consortium: Tumor Microenvironment and Drug Discovery, 2014. e-Pub 2014.
31. Liu Y, Tao X, Zhang Z, Jin H, Lu Y, Lu Z, Jr BR, Feng Y, Yu Y. Follicle-Stimulating Hormone Inhibits Apoptosis and Autophagy in Ovarian Cancer Cells by Activating Multiple Signaling Pathways. Gordon Research Conference on Autophagy in Stress, Development and Disease, 2014. e-Pub 2014.
32. Morgado M, Sutton M, Simmons M, Lu Z, Jr BR, Carson D. Cytokine Stimulation of MUC16 Expression in Human Endometrial and Ovarian Epithelial Cell Lines. Endocrine Society, 2013. e-Pub 2013.
33. Washington MN, Suh G, Orosco AF, Yang M, Wang W, Gao F, Atkinson EN, Liao W, Lu Z, Jr BR. ARHI-Induced Autophagy Enhances Chemosensitivity to Cisplatin in Human Ovarian Cancer Cell Lines and Xenografts. Proc Amer Assoc Cancer Res, 2013. e-Pub 2013.
34. Sutton MN, Lu Z, Bast RC. ARHI (DIRAS3) Family Members Inhibit Cell Growth and Proliferation While Inducing Autophagy in Human Ovarian Cancer Cells. Proc Amer Assoc Cancer Res, 2013. e-Pub 2013.
35. Raamanathan A, Lu Z, Jr BR, Skates SJ. Intra-person and Inter-person biomarker variation for modeling longitudinal values of ovarian cancer early detection biomarkers. Proc Amer Assoc Cancer Res, 2013. e-Pub 2013.
36. Yang H, Wang X, Ahmed AA, Lu Z, Jr BR. Knockdown of Kinases that Regulate Microtubule Stability and Centrosome Function Enhance Paclitaxel Sensitivity in Multiple Ovarian Cancer Cell Lines. Proc Amer Assoc Cancer Res, 2013. e-Pub 2013.
37. Lu Z, Liao WSL, Yang M, Gao F, Jr BR. ARHI Downregulates PI3K and Ras-MAP Signaling and Induces Autophagy by Promoting Integrin and EGFR Membrane Protein Degradation. Proc Amer Assoc Cancer Res. Proc Amer Assoc Cancer Res, 2012. e-Pub 2012.
38. Jr BR, Lokshin A, Skates S, Zhang Z, Lu Z, Baggerly K, Atkinson JN, Diao L, He WW, Bedi DG, Bevers T, Adeyinka O, Newland W, Moore R, Leeds L, Harris S, Fritsche H, Lu KH. Early Detection of Ovarian Cancer: The MDACC Ovarian SPORE Trial and Development of Strategies to Detect Preclinical Disease. Helene Harris Memorial Trust, 2011. e-Pub 2011.
39. Yu Y, Lu Z, Das P, Yang H, Feng W, Chen M, Jr BR. Multiple Imprinted Tumor Suppressor Genes in Ovarian Cancer. ICC Course on "Genomic imprinting and beyond – Monoallelic expression in health and disease, 2011. e-Pub 2011.
40. Zhang Z, Skates SJ, Sokoll LJ, Lu Z, Clarke CH, Hernandez MA, Lu KH, Bast RC. A Multivariate Longitudinal Algorithm for Early Detection of Ovarian Cancer Using Multiple Biomarkers. Proc Amer Soc Clin Oncol 29, 2011. e-Pub 2011.
41. Liao W, Lu Z, Gao F, Yang M, Jr BR. ARHI-Induced Autophagy is Mediated through Activation of FoxO3a and Induction of its Target Genes to Promote the Formation of Autophagic Complexes. Proc Amer Assoc Cancer Res 52, 2011. e-Pub 2011.
42. Mandal PK, Liao W, Gao F, Robertson F, Thudi N, Ekmekcioglu S, Chattopadhyay C, Ren Z, Chen X, Lu Z, Jr BR, McMurray JS. Potent, Highly Specific Peptidomimetic Targeting the SH2 Domain of Stat3 Decreases Vasculogenic Mimicry, Invasion and Anchorage Independent Growth of Cancer Cells. Proc Amer Assoc Cancer Res 51, 2010. e-Pub 2010.
43. Lu Z, Liao WSL, Suh GL, Jr BR. Integrin and FAK Signaling Regulate ARHI-Induced Autophagy. Proc Amer Assoc Cancer Res 51, 2010. e-Pub 2010.
44. Ahmed AA, Le XF, Lu Z, Mao M, Aiken A, Jr BR. Loss of CDK5 Sensitizes Cells to Paclitaxel by Enhancing Intracellular Retention. Proc Amer Assoc Cancer Res 51, 2010. e-Pub 2010.
45. Lu Z, Liao WSL, Jr BR. ARHI is Required for Induction of Beclin-1/PI(3)K Class III-Mediated Autophagy. Proc Amer Assoc Cancer Res 51, 2010. e-Pub 2010.
46. Jr BR, Skates S, Zhang Z, Coombes K, Atkinson EN, Lokshin A, Clarke C, Lu Z, Zheng JF, Das P, Badgwell D, Celestino J, Hernandez MA, Moore R, Granai C, Newland W, Shadur C, Adeyinka O, Harris SA, Fung E, Allard J, Somers E, Fritsche H, Menon U, Jacobs I, Lu KH. Early Detection of Ovarian Cancer: An Update. 7th International Symposium on Advanced Ovarian Cancer, 2009. e-Pub 2009.
47. Ahmed A, Jacomo RO, Lu Z, Das P, Zheng JF, Liao W, Andreeff M, Bast RC. The Salt Inducible Kinase 2 (SIK2) is Required for Centrosome Separation at the Onset of Mitosis. Proc Amer Assoc Cancer Res 50, 2009. e-Pub 2009.
48. Liao W, Lu Z, Elizondo S, Suh GK, Bast RC. ARHI-Induced Autophagy is Mediated through Transcription Factor FoxO3a and Can be Rescued by Growth Factors. Proc Amer Assoc Cancer Res 50, 2009. e-Pub 2009.
49. Ahmed A, Le XF, Lu Z, Bast RC. Kinase Regulated Microtubule Stabilization Correlates with Paclitaxel Response in a Target Specific siRNA Kinome Screen. Proc Amer Assoc Cancer Res 50, 2009. e-Pub 2009.
50. Lu Z, Badgwell DB, Le K, Suh GK, Das P, Andreeff M, Ahmed A, Liao WS, Bast RC. Re-Expression of the Tumor Suppressor Gene ARHI Suppresses Ovarian Cancer Cell Motility through Inhibition of Stat3 and the Rho/ROCK Signaling. Proc Amer Assoc Cancer Res 50, 2009. e-Pub 2009.
51. Le XF, Mao W, Lu Z, Bast RC. Dasatinib Induces Autophagy as well as Growth Arrest in Human Ovarian Cancer Cells. Proc Amer Assoc Cancer Res 50, 2009. e-Pub 2009.
52. Liao W, Lu Z, Elizondo S, Suh GK, Bast RC. ARHI-induced Autophagy is Mediated through Transcription Factor FoxO3a and Can be Rescued by Growth Factors. Proc Amer Assoc Cancer Res 50, 2009. e-Pub 2009.
53. Jr BR, Skates S, Zhang Z, Coombes K, Baggerly K, Atkinson EN, Lokshin A, Clarke C, Lu Z, Zheng JF, Das P, Badgwell D, Celestino J, Hernandez MA, Moore R, Granai C, Newland N, Shadur C, Adeyinka O, Harris SA, Fung E, Allard J, Somers E, Fritsche H, Menon U, Jacobs I, Lu K. Optimizing a Two-Stage Strategy for Early Detection of Ovarian Cancer. NCI Translates. NCI Translational Science Meeting 300, 2008. e-Pub 2008.
54. Lu Z, S-L LW, Yu Y, Le K, Elizondo S, Cheng KW, Lu Y, Luo R, Kondo S, Mills GB, Jr BR. Tumor Suppressor Gene ARHI (DIRAS3) is Required for Spontaneous and Rapamycin-Induced Autophagy in Normal and Ovarian Cancer Cells. Proc Amer Assoc Cancer Res 49, 2008. e-Pub 2008.
55. Das P, Lu Z, Bedi A, Marquez R, Atashroo D, Yinhua Y, Jr BR. Downregulation of Multiple Imprinted Gene in Ovarian Cancer. Proc Amer Assoc Cancer Research 433, 2008. e-Pub 2008.
56. Lu Z, Liao W Yu Y, Kim L, Elizondo S, Cheng KW, Lu Y, Luo RZ, Kondo S, Mills GB, Jr BR. Tumor Suppressor Gene ARHI (DIRAS3) is Required for Spontaneous and Repamycin-Induced Autophagy in Normal and Ovarian Cell. Proc Amer Assoc Cancer Research, 2008. e-Pub 2008.
57. Yu Y, Hu X, Huang S, Lu Z, Luo R, Liao W, X-F Q, Jr BR. Knockdown of ARHI Promotes the Proliferation of Normal Breast and Ovarian Epithelial Cells and Enhances Breast Cancer Growth. Proc Amer Assoc Cancer Res 49, 2008. e-Pub 2008.
58. Lu Z, Luo RZ, Zhang X, Yu Y, Jr BR. A Novel Tumor Suppressor Gene ARHI (DIRAS3) Enhances Polymerization of Microtubules and Increases the Anti-Tumor Activity of Paclitaxel. Proc Amer Assoc Cancer Research, 2007. e-Pub 2007.
59. M-Y C, Yu Y, Lu Z, Rosner GL, Atkinson EN, Fu S, Kavanagh J, Jr BR. Synergistic Inhibition of Ovarian Cancer Cell Growth with Demethylating Agents and Histone Deacetylase Inhibitors. Proc Amer Assoc Cancer Research, 2007. e-Pub 2007.
60. D-J C, Wang Y, C-M C, Lu Z, Luo RZ, Cunningham SL, Xing D, Orsulic S, Jr BR, Behringer RR. Functional Studies of the Ovarian Cancer Antigen CA125 (Mucin 16) in the Mouse. Proc Amer Assoc Cancer Research, 2007. e-Pub 2007.
61. Luo RZ, Lu Z, Lu Y, Zhang X, Yu Q, Khare S, Kondo S, Kondo Y, Yu Y, Liao W, Mills GB, Jr BR. A Novel Tumor Suppressor Gene ARHI Induces Autophagy and Tumor Dormancy in Ovarian Cancer. Proc Amer Assoc Cancer Research, 2007. e-Pub 2007.
62. Badgwell D, Lu Z, Luo R, Yu Y, J-J B, Liao W, Jr BR. Re-Expression of the Tumor Suppressor Gene ARHI Decreases Ovarian Cancer Cell Motility by Inhibiting STAT3 Signaling. Proc Amer Assoc Cancer Research, 2007. e-Pub 2007.
63. Huang S, Chang IS, Luo RZ, Lu Z, Jr BR, Chen X, Yu Y. The ARHI Tumor Suppressor Gene May Prevent Nuclear Translocation of p-STAT3 by Antagonizing the Interaction of Ran with Importin Proteins. Proc Amer Assoc Cancer Research, 2007. e-Pub 2007.
64. Badgwell D, Lu Z, Fritsche H, Atkinson EN, Sommers E, Allard J, Moore R, Lu K, Bast RC, Jr. Soluble Mesothelin-Related Protein (SMRP) is Elevated in the Serum and Urine of Patients with Early Stage Ovarian Cancer. 10th Annual SPORE Workshop, 2006. e-Pub 2006.
65. Moore RG, Brown AK, Miller MC, Badgwell D, Lu Z, Verch T, Allard WJ, Granai CO, Bast R, Lu K. Utility of a Novel Serum Tumor Biomarker HE4 in Patients with Uterine Cancer. Proc Amer Soc Clin Oncol 24, 2006. e-Pub 2006.
66. Moore RG, Brown AK, Miller MC, Lu Z, Badgwell D, Verch T, Allard WJ, Lu K, Granai CO, Bast R. A Novel Multiple Biomarker Assay for the Detection of Ovarian Cancer. Proc Amer Soc Clin Oncol 24, 2006. e-Pub 2006.
67. Feng W, Marquez RT, Lu Z, Liu J, Lu KH, Yu Y, Jr BR. Genetic and Epigenetic Regulation of Two Imprinted Tumor Suppressor Genes – ARHI and PEG3 – in Ovarian Cancer. Proc Amer Assoc Cancer Res, 2006. e-Pub 2006.
68. Lu Z, Luo R, Khare S, Wang Y, Cheon DJ, Chen CM, Behringer RR, Jr BR. Distribution of Murine MUC16, a Homolog of Human Ovarian Cancer Marker CA125, in Adult Murine Reproductive Tissues. Proc Amer Assoc Cancer Res, 2006. e-Pub 2006.
69. Luo R, Lu Z, Lu Y, Khare S, Kondo S, Kondo Y, Yu Y, Liao WS, Mills GB, Jr BR. A novel Tumor Suppressor Gene ARHI Induces Autophagy in Ovarian Cancer. Proc Amer Assoc Cancer Res:#4094, 2006. e-Pub 2006.
70. Jr BR, Marquez R, Lu Z, Luo R, J-J B, Feng W, Rosen D, Liu J, Lu K, Mills G, Gershenson D, Liao W, Yu Y. Imprinted Tumor Suppressor Genes in Epithelial Ovarian Cancer. Helene Harris Memorial Trust 10th Biennial International Forum on Ovarian Cancer, 2005. e-Pub 2005.
71. Lu Z, Luo RZ, Khare S, Yu Y, Jr BR. Inducible Expression of Tumor Suppressor Gene ARHI in Ovarian Cancer Cells Triggers G2M Arrest and Inhibits Cancer Cell Growth in Vitro and in Vivo. Proc Amer Assoc Cancer Res 46:2895, 2005. e-Pub 2005.
72. Luo R, Lu Z, Khare S, Yu Y, Jr BR. Expression of the Tumor Suppressor Gene ARHI Induces Autophagic Cell Death in Ovarian Cancer Cells. Proc Amer Assoc Cancer Res 46:844, 2005. e-Pub 2005.
73. Feng W, Lu Z, Luo R, Zhang X, Seto E, Jr BR, Yu Y. The ARHI Tumor Suppressor Gene is Repressed by Multiple Histone Deacetylases (HDACs) in Breast Cancer. Proc Amer Assoc Cancer Res 46:2732, 2005. e-Pub 2005.
74. Yu Y, J-J B, Fang B, Lu Z, Luo RZ, RC Jr AB. ARHI Gene Therapy and Paclitaxel Exert Additive Cytotoxicity for Breast Cancer Cells through Caspase-Independent and Caspase-Dependent Apoptotic Mechanisms. The 16th EORTC-NCI-AACR Symposium on "Molecular Targets and Cancer Therapeutics, 2004. e-Pub 2004.
75. Yu Y, Lu Z, Luo RZ, Peng H, Nishmoto A, Huang M, WS-L L, RC Jr AB. Transcriptional Regulation of the Tumor Suppressor Gene ARHI by E2F-HDAC Complexes in Breast and Ovarian Cancers. Chromatin structure and gene expression mechanisms as therapeutic targets, 2004. e-Pub 2004.
76. Nishimoto A, Yu Y, Lu Z, Ren Z, Mao X, Watowich SS, Mills GB, Liao W, Chen X, Jr BR. ARHI Directly Inhibits STAT3 Translocation and Activity in Human Breast and Ovarian Cancer Cells. Proc Amer Assoc Cancer Res 45:412, 2004. e-Pub 2004.
77. Lu Z, Luo RZ, Peng H, Nishimoto A, Huang M, WS-L L, Jr BR, Yu Y. E2F-HDAC Complexes Downregulate Expression of the Tumor Suppressor Gene ARHI in Breast Cancer Cell Lines. Proc Amer Assoc Cancer Res 45:809 (A#3508), 2004. e-Pub 2004.
78. Nishimoto A, Yu Y, Lu Z, Liao, S-L W, Jr BR, Luo RZ. A Novel Tumor Suppressor Gene Interacts with and Inhibits STAT3 Activity in Breast and Ovarian Cancer. Proteomics 3:80, 2004. e-Pub 2004.
79. Lu Z, Luo RZ, Peng HX, Yu Y, Jr BR. Transcriptional and Post-Transcriptional Regulation of the Imprinted Tumor Suppressor Gene ARHI in Breast and Ovarian Cancers. Proc Amer Assoc Cancer Res 44:1138, 2003. e-Pub 2003.

Book Chapters

1. Sutton MN, Lu Z, Bast RC. The Role of Angiogenesis, Growth Arrest and Autophagy in Human Ovarian Cancer Xenograft Models for Tumor Dormancy. In: Tumor Dormancy, Quiescence, and Senescence. 1. Springer Netherlands, 99-109, 2014.
2. Lu Z, Bast RC. Tumor suppressor genes. In: Cancer Treat Res, 109-29, 2009.
3. Lu Z, Feng W, Luo RZ, Liao WSL, Jr BR, Yu Y. E2F-HADC complexes regulate tumor suppressor gene in cancer. In: Control of Cellular Physiology by E2F Transcription Factors, 303-307, 2008.