Zhihong Hu, M.D., Ph.D.
Department of Laboratory Medicine, Division of Pathology-Lab Medicine Div
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Pathology/Laboratory Medicine, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1993 | Bethune University of Medical Science, Changchun, CHN, MD, Clinical Medicine |
Postgraduate Training
| 2015-2017 | Clinical Fellowship, Hematopathology, The University of Texas at MD Anderson Cancer Center (UT-MDACC), Houston, TX |
| 2014-2015 | Clinical Fellowship, Surgical Pathology, Loyola University Medical Center (LUMC), Maywood, IL |
| 2010-2014 | Clinical Residency, Anatomic Pathology and Clinical Pathology, Loyola University Medical Center (LUMC), Maywood, IL |
| 2005-2006 | Research Fellowship, The University of Chicago, Chicago, IL |
Board Certifications
| 2016 | American Board of Pathology, Hematology |
| 2015 | American Board of Pathology, Anatomic and Clinical Pathology |
Experience & Service
Academic Appointments
Assistant Professor, Department of Pathology/Laboratory Medicine, The University of Texas Health Center at Houston, Houston, TX, 2017 - 2022
Research Associate, Department of Pathology, University of Chicago, Chicago, IL, 2005 - 2006
Medical Research Scientist, Institute of Space Medico-Engineering of China, Beijing, 1993 - 1999
Administrative Appointments/Responsibilities
Research Specialist/Supervisor, Department of Physiology, Loyola University Medical Center (LUMC), Maywood, IL, 2008 - 2010
Institutional Committee Activities
Member, Harris Health System Laboratory Utilization and Stewardship Committee, 2022 - Present
Member, Harris Health Laboratory Supply Equipment and Contracts Review Committee, 2022 - Present
Member, Harris Health Cancer Committee, 2020 - Present
Honors & Awards
| 2022 | Dean's Teaching Excellence Award, The University of Texas Health Science Center at Houston, TX |
| 2022 | Best Investigative Poster Presentation, TSP Annual Meeting |
| 2022 | Best Investigative Platform Presentation, TSP Annual Meeting |
| 2021 | Dean's Teaching Excellence Award, The University of Texas Health Science Center at Houston, TX |
| 2021 | Best Case Report Poster Presentation, TSP Annual Meeting |
| 2021 | Best Investigative Poster Presentation, TSP Annual Meeting |
| 2017 | The Shannon Timmins Fellowship for Leukemia Research, The University of Texas MD Anderson Center |
| 2011 | Best Infectious Disease Presentation |
| 2011 | Best Infectious Disease Presentation Award, 100th Annual Meeting of USCAP, Binford-Dammin Society of Infectious Disease Pathologists |
| 2010 | Stowell-Orbison, Surgical Pathology and/or Autopsy Award (2nd Author), Annual Meeting of USCAP |
| 2004 | Travel Award, The Shock Society, Annual Shock Conference |
| 2003 | Travel Award, The Shock Society, Annual Shock Conference |
| 2003 | Young Investigator Award, The Shock Society, Annual Shock Conference |
| 1997 | Outstanding Young Researcher of the Year, Institute of Medico-Space Engineering |
| 1996 | Outstanding Young Researcher of the Year, Institute of Medico-Space Engineering |
| 1992 | Award for Outstanding Students, Bethune University of Medical Sciences |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Wang W, Gehris BT, Mai B, Chen L, Hu S, You MJ, Hu Z. HHV8-Negative Effusion-Based lymphoma in a patient with recurrent HCV hepatitis status post liver transplantation. Leuk Lymphoma 63(14):3480-3483, 2022. e-Pub 2022. PMID: 36154351.
- Fang H, Wang SA, Khoury JD, El Hussein S, Kim DH, Tashakori M, Tang Z, Li S, Hu Z, Jelloul FZ, Patel KP, McDonnell TJ, Kadia T, Medeiros LJ, Wang W. Pure erythroid leukemia is characterized by biallelic TP53 inactivation and abnormal p53 expression patterns in de novo and secondary cases. Haematologica 107(9):2232-2237, 2022. e-Pub 2022. PMID: 35511670.
- Wang X, Tang G, Hu Z, Fang H, Wang W, Tang Z, Toruner GA, Zhou T, DiNardo CD, Garcia-Manero G, Verstovsek S, Bueso-Ramos CE, Medeiros LJ, Hu S. Myeloid neoplasms with 8q24/MYC rearrangement are frequently associated with myelodysplasia, complex karyotype, TP53 alterations, and inferior survival. Br J Haematol 198(3):604-608, 2022. e-Pub 2022. PMID: 35645146.
- Li R, Saluja K, Lin M, Hu Z, Cai Z, Zhu H. Sinonasal Hamartomas: From Nasal Chondromesenchymal Hamartoma to Respiratory Epithelial Adenomatoid Hamartoma. Report of six Cases and Review of the Literature. Int J Surg Pathol 30(4):448-456, 2022. e-Pub 2022. PMID: 35001691.
- Fang H, Wang W, Zhang L, Shen Q, Yuan J, Reichard KK, Hu Z, Medeiros LJ. Reactive Intralymphovascular Immunoblastic Proliferations Mimicking Aggressive Lymphomas. Am J Surg Pathol 46(3):326-335, 2022. PMID: 34310368.
- Ricks E, Hu S, Hu Z. Cytokeratin-positive follicular dendritic cell sarcoma: A mimic of carcinoma. EJHaem 3(1):254-255, 2022. e-Pub 2021. PMID: 35846219.
- Ghosh A, Chen L, Wahed A, Wang W, Saluja K, Nguyen AND, Hu S, Hu Z. Incidental but rapidly progressing T-cell prolymphocytic leukemia with t(X;14)(q28;q11) involving parotid lymphoepithelial cysts: A diagnostic pitfall. Int J Lab Hematol 44(1):e17-e20, 2022. e-Pub 2021. PMID: 34275205.
- Wang W, Hu Z. Leukocytosis with left-shifted myeloid maturation in a peripheral blood specimen: a clue to the lymphoid blast phase of CML. Blood 139(2):305, 2022. PMID: 35024807.
- Xia M, Wu L, Sun X, Han X, Yan H, Huang J, Zhang Y, Hu Z, Zu Y, Yin CC, Qiu X. Next-Generation Sequencing Revealed a Distinct Immunoglobulin Repertoire with Specific Mutation Hotspots in Acute Myeloid Leukemia. Biology (Basel) 11(2), 2022. e-Pub 2022. PMID: 35205028.
- Mai B, Friscia M, Elzamly S, Thomas-Ogunniyi J, Wahed A, Nguyen A, Hu Z, Cai Z, Chen L. Obesity Is a Risk Factor Associated with H. pylori-negative MALT Lymphoma of Stomach. Ann Clin Lab Sci 51(5):609-614, 2021. PMID: 34686502.
- Tang Y, Kortum A, Vohra I, Schwarz RA, Carns J, Kannady CR, Clavell-Hernandez J, Hu Z, Dhanani N, Richards-Kortum R. Initial Results of First In Vivo Imaging of Bladder Lesions Using a High-Resolution Confocal Microendoscope. J Endourol 35(8):1190-1197, 2021. e-Pub 2021. PMID: 33307957.
- Hu Z, Singhi EK, Apostolidou E, Mai B, Juneja HS, Hu S. Mass-forming neoplastic extramedullary hematopoiesis mimics myeloid sarcoma in a patient with chronic phase chronic myeloid leukemia. Int J Lab Hematol 43(3):e135-e137, 2021. e-Pub 2020. PMID: 33314782.
- Hu Z, Wang W, Thakral B, Chen Z, Estrov Z, Bueso-Ramos CE, Verstovsek S, Medeiros LJ, Wang SA. Lymphocytic variant of hypereosinophilic syndrome: A report of seven cases from a single institution. Cytometry B Clin Cytom 100(3):352-360, 2021. e-Pub 2020. PMID: 32157815.
- Hu Z, Pan Z, Chen W, Shi Y, Wang W, Yuan J, Wang E, Zhang S, Kurt H, Mai B, Zhang X, Liu H, Rios AA, Ma HY, Nguyen ND, Medeiros LJ, Hu S. Primary Effusion Lymphoma: A Clinicopathological Study of 70 Cases. Cancers (Basel) 13(4), 2021. e-Pub 2021. PMID: 33669719.
- Mai B, Wang W, Lin M, Hu S, Wang XI, Chen L, Wahed A, Nguyen A, Ma HY, Medeiros LJ, Hu Z. HIV-associated plasmablastic lymphoma in the era of HAART: a single-center experience of 21 patients. AIDS 34(12):1735-1743, 2020. PMID: 32889849.
- Dodge DL, Cherian SV, Ali YD, Murzabdillaeva A, Hu Z, Estrada-Y-Martin RM. A 35-Year-Old Woman With Progressive Dyspnea and Cough. Chest 158(3):e103-e106, 2020. PMID: 32892884.
- Mai B, Saluja K, Hu Z, Nguyen ND, Wahed A, Wang XI, Chen L. Educational Case: Mantle Cell Lymphoma. Acad Pathol 7:2374289520932286, 2020. e-Pub 2020. PMID: 32671196.
- Mai B, Wahed MA, Chen L, Nguyen ND, Wang XI, Hu Z. Educational Case: Systemic Mastocytosis with an Associated Hematological Neoplasm. Acad Pathol 7:2374289520906526, 2020. e-Pub 2020. PMID: 32158933.
- El Achi H, Glass WF, Wang W, Medeiros LJ, Hu Z. Reactive lymphadenopathy with concurrent idiopathic plasma cell variant Castleman disease, amyloid deposition and non-caseating granulomas. Pathology 51(7):762-764, 2019. e-Pub 2019. PMID: 31662201.
- Mai B, Wang W, Medeiros LJ, Ma HY, Hu Z. TdT-positive high grade B-cell lymphoma transformed from grade 3B follicular lymphoma in an HIV-positive patient. Pathology 51(7):764-768, 2019. e-Pub 2019. PMID: 31666176.
- Jaitly V, Hu Z, Ayala G, Wahed MA, Nguyen ND, Brown RE. M2 Macrophages in Crystal Storing Histiocytosis Associated with Plasma Cell Myeloma. Ann Clin Lab Sci 49(5):666-670, 2019. PMID: 31611212.
- Xu J, Wang L, Li J, Saksena A, Wang SA, Shen J, Hu Z, Lin P, Tang G, Yin CC, Wang M, Medeiros LJ, Li S. SOX11-negative Mantle Cell Lymphoma: Clinicopathologic and Prognostic Features of 75 Patients. Am J Surg Pathol 43(5):710-716, 2019. PMID: 30768440.
- Hu Z, Ramos CEB, Medeiros LJ, Zhao C, Yin CC, Li S, Hu S, Wang W, Thakral B, Xu J, Verstovsek S, Lin P. Utility of JAK2 V617F allelic burden in distinguishing chronic myelomonocytic Leukemia from Primary myelofibrosis with monocytosis. Hum Pathol 85:290-298, 2019. e-Pub 2018. PMID: 30447300.
- Achi HE, Belousova T, Chen L, Wahed A, Wang I, Hu Z, Kanaan Z, Rios A, Nguyen AND. Automated Diagnosis of Lymphoma with Digital Pathology Images Using Deep Learning. Ann Clin Lab Sci 49(2):153-160, 2019. PMID: 31028058.
- Angelova EA, Medeiros LJ, Wang W, Muzzafar T, Lu X, Khoury JD, Ravandi F, Patel KP, Hu Z, Kanagal-Shamanna R. Clinicopathologic and molecular features in hairy cell leukemia-variant: single institutional experience. Mod Pathol 31(11):1717-1732, 2018. e-Pub 2018. PMID: 29955146.
- Hu Z, Boddu PC, Loghavi S, Miranda RN, Goswami M, Medeiros LJ, Tam W, Orazi A, Verstovsek S, Wang SA. A multimodality work-up of patients with Hypereosinophilia. Am J Hematol 93(11):1337-1346, 2018. e-Pub 2018. PMID: 30105844.
- Sun Y, Tang G, Hu Z, Thakral B, Miranda RN, Medeiros LJ, Wang SA. Comparison of karyotyping, TCL1 fluorescence in situ hybridisation and TCL1 immunohistochemistry in T cell prolymphocytic leukaemia. J Clin Pathol 71(4):309-315, 2018. e-Pub 2017. PMID: 28821581.
- Hu Z, Sun Y, Schlette EJ, Tang G, Li S, Xu J, Yin CC, Young KH, Patel KP, Miranda RN, Goswami M, Wang M, Jorgensen JL, Medeiros LJ, Wang SA. CD200 expression in mantle cell lymphoma identifies a unique subgroup of patients with frequent IGHV mutations, absence of SOX11 expression, and an indolent clinical course. Mod Pathol 31(2):327-336, 2018. e-Pub 2017. PMID: 28984300.
- Hu Z, Hu S, Ji C, Tang Z, Thakral B, Loghavi S, Medeiros LJ, Wang W. 3q26/EVI1 rearrangement in myelodysplastic/myeloproliferative neoplasms: An early event associated with a poor prognosis. Leuk Res 65:25-28, 2018. e-Pub 2017. PMID: 29288910.
- Quesada AE, Hu Z, Routbort MJ, Patel KP, Luthra R, Loghavi S, Zuo Z, Yin CC, Kanagal-Shamanna R, Wang SA, Jorgensen JL, Medeiros LJ, Ok CY. Mixed phenotype acute leukemia contains heterogeneous genetic mutations by next-generation sequencing. Oncotarget 9(9):8441-8449, 2018. e-Pub 2018. PMID: 29492206.
- Hu Z, Sun Y, Wang W, Medeiros LJ, Kanagal-Shamanna R. Refractory hairy cell leukemia-variant. Am J Hematol 92(12):1398-1399, 2017. e-Pub 2016. PMID: 27727469.
- Hu Z, Konoplev S. Aleukemic mast cell leukemia associated with chronic myelomonocytic leukemia and chronic lymphocytic leukemia. Blood 130(19):2150, 2017. PMID: 29122774.
- Hu Z, Li S, Medeiros LJ, Sun T. TCL-1-positive hematogones in a patient with T-cell prolymphocytic leukemia after therapy. Hum Pathol 65:175-179, 2017. e-Pub 2017. PMID: 28232160.
- Hu Z, Medeiros LJ, Wang W, Chen Z, Tang G, Hodjat P, Yang S, Fang L, Li Y, Verstovsek S, Hu S. 3q26.2/EVI1 rearrangement is associated with poor prognosis in classical Philadelphia chromosome-negative myeloproliferative neoplasms. Mod Pathol 30(7):940-951, 2017. e-Pub 2017. PMID: 28338652.
- Hidalgo-López JE, Kanagal-Shamanna R, Quesada AE, Thakral B, Hu Z, Mitsuhashi T, Yabe M, Garcia-Manero G, Bueso-Ramos CE. Progress in Myelodysplastic Syndromes: Clinicopathologic Correlations and Immune Checkpoints. Clin Lymphoma Myeloma Leuk 17S:S16-S25, 2017. PMID: 28760297.
- Hu Z, Medeiros LJ, Fang L, Sun Y, Tang Z, Tang G, Sun T, Quesada AE, Hu S, Wang SA, Pei L, Lu X. Prognostic significance of cytogenetic abnormalities in T-cell prolymphocytic leukemia. Am J Hematol 92(5):441-447, 2017. e-Pub 2017. PMID: 28194886.
- Hu Z, Medeiros LJ, Chen Z, Chen W, Li S, Konoplev SN, Lu X, Pham LV, Young KH, Wang W, Hu S. Mantle Cell Lymphoma With MYC Rearrangement: A Report of 17 Patients. Am J Surg Pathol 41(2):216-224, 2017. PMID: 27776009.
- Wang W, Chen Z, Hu Z, Yin CC, Li S, Bai S, Bueso-Ramos CE, Medeiros LJ, Hu S. Clinical significance of trisomy 8 that emerges during therapy in chronic myeloid leukemia. Blood Cancer J 6(11):e490, 2016. e-Pub 2016. PMID: 27813536.
- Hu Z, Sun T. Blastic plasmacytoid dendritic cell neoplasm associated with chronic myelomonocytic leukemia. Blood 128(12):1664, 2016. PMID: 28092882.
- McCroskey Z, Bahar B, Hu Z, Wojcik EM, Barkan GA. Subclassifying atypia in urine cytology: what are the helpful features?. J Am Soc Cytopathol 4(4):183-189, 2015. e-Pub 2014. PMID: 31051752.
- Hu Z, Mudaliar K, Quek ML, Paner GP, Barkan GA. Measuring the dimension of invasive component in pT1 urothelial carcinoma in transurethral resection specimens can predict time to recurrence. Ann Diagn Pathol 18(2):49-52, 2014. e-Pub 2013. PMID: 24370460.
- Bahar B, Hu Z, Szpaderska A, Liotta M, Potkul RK, Smith D, Ersahin Ç. Fatal case of luteinized thecoma with sclerosing peritonitis in a 40-year-old woman. Int J Gynecol Pathol 33(1):30-4, 2014. PMID: 24300532.
- Pallikkuth S, Blackwell DJ, Hu Z, Hou Z, Zieman DT, Svensson B, Thomas DD, Robia SL. Phosphorylated phospholamban stabilizes a compact conformation of the cardiac calcium-ATPase. Biophys J 105(8):1812-21, 2013. PMID: 24138857.
- Hu Z, Chou PM, Jennings LJ, Arva NC. Infantile fibrosarcoma-a clinical and histologic mimicker of vascular malformations: case report and review of the literature. Pediatr Dev Pathol 16(5):357-63, 2013. e-Pub 2013. PMID: 23718697.
- Hou Z, Hu Z, Blackwell DJ, Miller TD, Thomas DD, Robia SL. 2-Color calcium pump reveals closure of the cytoplasmic headpiece with calcium binding. PLoS One 7(7):e40369, 2012. e-Pub 2012. PMID: 22808146.
- Hu Z, Wang Y, Graham WV, Su L, Musch MW, Turner JR. MAPKAPK-2 is a critical signaling intermediate in NHE3 activation following Na+-glucose cotransport. J Biol Chem 281(34):24247-53, 2006. e-Pub 2006. PMID: 16793766.
- Hu Z, Sayeed MM. Activation of PI3-kinase/PKB contributes to delay in neutrophil apoptosis after thermal injury. Am J Physiol Cell Physiol 288(5):C1171-8, 2005. e-Pub 2004. PMID: 15625305.
- Hu Z, Sayeed MM. Suppression of mitochondria-dependent neutrophil apoptosis with thermal injury. Am J Physiol Cell Physiol 286(1):C170-8, 2004. e-Pub 2003. PMID: 13679304.
- Hu Z, Zhao G, Xiao Z, Chen X, Zhong C, Yang J. Different responses of cerebral vessels to -30 degrees head-down tilt in humans. Aviat Space Environ Med 70(7):674-80, 1999. PMID: 10417003.
- Zhao GX, Yang JS, Zhong CF, Lu LL, Hu ZH. [Star figure in medical monitoring during lower body negative pressure test]. Space Med Med Eng (Beijing) 12(2):101-5, 1999. PMID: 12430534.
- Yang J, Zhao G, Zhong C, Hu Z, Lu L. [Heart rate variability analysis under lower body negative pressure]. Space Med Med Eng (Beijing) 11(6):430-4, 1998. PMID: 11543380.
- Zhao G, Hu Z, Yang J, Zhong C. [Changes of cervical blood flow in subjects with different tolerances to -30 degrees head-down bed rest]. Space Med Med Eng (Beijing) 11(5):324-8, 1998. PMID: 11543252.
- Hu Z, Zhao G, Yang J, Jiao J, Zhong C, Lu L. Linear and nonlinear analysis of heart rate variability during lower body negative pressure. Space Med Med Eng (Beijing) 11(4):235-9, 1998. PMID: 11543238.
- Hu Z, Liu Y, Zhong C, Zhao G, Liu B. [Nonlinear dynamic analysis of heart rate variability during exercise]. Space Med Med Eng (Beijing) 11(2):111-5, 1998. PMID: 11543226.
Book Chapters
- Bittar EE, Khurana S.. Mechanisms of ion transport and regulation by microfilaments. In: Advances in Molecular and Cell Biology: Aspects of the Cytoskeleton, 2006.
Grant & Contract Support
| Title: | Prognostic Implications of IGH Rearrangement in AML |
| Funding Source: | The University of Texas MD Anderson Cancer Center |
| Role: | Co-Principal Investigator |
| Title: | Pre-Doctoral Fellowship Grant |
| Funding Source: | Loyola University Medical Center |
| Role: | Student |