Meet Zhongxing Liao, M.D.
Zhongxing Liao, M.D.
Department of Radiation Oncology, Division of Radiation Oncology
About Dr. Liao
Dr. Liao's research activities aim to improve the therapeutic ratio of radiotherapy for thoracic malignancies through translational research. Specifically, her efforts focus on personalizing chemoradiotherapy for lung cancer by reducing treatment-related toxicity, and increasing cancer cure rates by using predictive biomarker strategies and advanced radiation delivery technology. She has continued her leadership role in conducting practice-changing clinical trials locally and nationally.
Dr. Liao's five most significant contributions in research include the following:
Successfully designed, led, and completed the first of the kind prospective randomized trial comparing IMRT and proton therapy for lung cancer. Dr. Liao is Principal Investigator of the first prospective randomized NCI PO1 funded multi-institutional trial “ A Bayesian Randomized trial of Image-Guided Adaptive Conformal Photon vs Proton Therapy, with Concurrent Chemotherapy, for Locally Advanced Non-Small Cell Lung Carcinoma: Treatment-Related Pneumonitis and Locoregional Recurrence ( NCT00915005)”. This clinical protocol compared proton and photon therapy for a “hard to treat” cancer. This protocol was critical in securing funding for her program project grant 2-P01CA021239, “Optimizing Proton Therapy,” PI Thomas Delaney; 9/25/2008−7/31/2013; $8,734,885 ($1,775,617/year). The hypothesis of this trial was based on the research findings from item 2 below, that the unique dosimetric characteristics of proton beams will reduce the dose and volume of the normal lung to radiation, hence further decreasing treatment-related lung toxicity. This protocol met the enrollment goal on 3/2014, and the first result was reported on 2016 ASCO meeting as a plenary presentation and included in the 2016 Best of ASCO. The manuscript was first submitted to the Lancet Journal with recommended transfer to the Lancet Respiratory Medicine, which she declined. The final version of the manuscript was resubmitted to JCO.
Translational research on secondary analyses on the data accumulated from protocol NCT00915005. This trial contributed greatly to the understanding of proton therapy and produced much valuable data. Dr. Liao worked with collaborators and was able to secure funding for a U19 ( 2U19CA021239-35, NIH/NCI, PI - Radhe Mohan, 9/25/2014-8/31/2018, $1,925,520 ($385,104/year) ), and a CPRIT ( RP160232, PI - Dragan Mirkovic/Pablo Yepes, 3/1/2016-2/28/2019, $835,395 ($275,114/year)) grant to perform secondary analyses on the data accumulated from this trial. Given the rapid proliferation of proton therapy facilities worldwide despite the lack of level I evidence of its effectiveness in lung cancer, Dr. Liao believes that the results are potentially practice-changing. She expects that results from ongoing analyses of secondary objectives including imaging, patient-reported outcomes, blood biomarkers, and cost effectiveness will considerably advance the state of the art in proton therapy, as will ongoing translational research to correlate biological and physical factors affecting response to protons vs. photons and radiation physics studies to assess the influence of uncertainties on proton therapy.
Established a bio-specimen repositories for biomarker research and facilitate translational research. This research effort is an expansion of the clinical trial as one of the secondary objectives and two protocols (Protocol Lab 2009-0307, PA13-0786). The aim is to identify predictive biomarkers for treatment outcome and to help select patients for the most effective treatment. The collected biospecimen including blood, plasma, serum, genome DNA, urine, and saliva are a rich resource for correlative studies to facilitate extramural funding. One example is that, using the blood samples from this study, combined with the clinical and radiation therapy dosimetric data, Dr. Liao is able to spearhead a research effort to study cardiac injury after chemoradiation for lung cancer. In the scope of the work, she has established research contract with ROCHE to use their high sensitive Cardiac Troponin kits to obtain preliminary data for extramural funding. Dr. Liao's R21 grant (1R21 CA222749-01) is entitled “Proton therapy to reduce heart damage for lung cancer patients”. Under the umbrellas of biomarker study and the infrastructure that she created, the thoracic service has accumulated a significant amount of biospecimen and clinical data on patients received concurrent chemoradiation treatment in the department of Radiation Oncology. The collaborative research effort has been expanded nationally and internationally with MGH, MAASTRO.
Becoming a national leader in clinical trials on proton therapy. Proton therapy is more costly than even the best currently available photon technology, and evidence demonstrating clinical benefit is increasingly demanded to justify the financial burden on the healthcare system. However, randomized trials comparing outcomes between different treatment technologies are practically non-existent, and trials of protons vs. photons are no exception. To establish level 1 evidence for proton therapy, we worked with the leadership of Corporate group RTOG (now NRG) and institutions and hospitals with proton facilities (total 15 now and the number continues to increase) and developed RTOG 1308, a “Phase III Randomized Trial Comparing Overall Survival after Photon versus Proton Radiochemotherapy for Inoperable Stage II-IIIB NSCLC”. This protocol was funded through CTEP. She serves as the Principle Investigator for this historical protocol in the history of particle therapy for thoracic malignancies. This trial has been active since 2014, and a total of 99 patients have been recruited to this trial. This phase III trial is probably the only opportunity for radiation oncology community to compare the survival after photons and protons chemoradiation for lung cancer patients.
Continuing her efforts in research of technological advancement including proton, Dr. Liao is leading another Randomized Phase I/II trial of image-guided, intensity-modulated photon (IMRT) or scanning beam proton therapy (IMPT) both with simultaneous integrated boost (SIB) dose escalation to the gross tumor volume (GTV) with concurrent chemotherapy for stage II/III non-small cell lung cancer (NSCLC) (MDA protocol: 2011-1058). This protocol use a novel radiation therapy technique called simultaneous integrated boost, which will delivery differential higher doses to tumor and lower dose to normal structure. This trial is significant because it is the only protocol that assess the impact of intensity modulated radiation therapy using either photon or protons, whereas the all the previous trials compared 3D Conformal proton with intensity modulated photons. She has completed the phase I portion and currently on phase II portion of this trial.
Expanded research collaborations with imaging, symptom research, and behavior science.
Dr. Liao has continued a long term collaboration with the symptom research department in the institution and was a Co-Principal Investigator on an R21 grant that investigated correlation of inflammatory cytokines and symptom burden in lung cancer patients who underwent chemoradiation. The final result has been published in the Journal of Clinical Oncology. The institution was awarded an RO1 grant entitled “ Reducing the symptom burden produced by aggressive cancer therapies", 5 R01 CA026582-31, NIH/NCI, PI - Charles Cleeland, 5/1/2013-4/30/2015”. $424,012 ($84,800/year). We are the first group reporting decreased symptom burden in patients treated with proton radiation compared with those treated with IMRT or 3D CRT.
- Dr. Liao has always been interested in imaging biomarker. She has received sister institution network finding for a project “Diffusion-weighted magnetic resonance imaging for early response assessment of neoadjuvant chemoradiation for squamouse cell carcinoma of the esophagus, Sister Institution Network Fund Application, UTMDACC, 1/1/2015-12/31/2016, $99,998 ($49,999/year)”. This project is a collaborative effort with 3 institutions in China and MD Anderson Cancer Center, and this project is ongoing.
- Dr. Liao is the institutional PI for another innovative project “A Randomized Trial of Incentives for Research Participation, (1R01CA197332-01, NIH/NCI, PI - Scott D. Halpern, 7/1/2015-6/30/2020, $288,642, ($67,841/year)). This clinical trial is built upon the population of RTOG 1308m to address the question if financial incentives impacts on patient participation of clinical trial. This project is currently ongoing as well.
Dr. Liao's translational and clinical research activities have been highly productive, as evidenced in her CV by publications in highly respected peer-reviewed scientific journals, by invitations to write review articles, and by invitations to national and international meetings as keynote or panel speakers. She has accumulated rich experience and knowledge, developed leadership skills and effectiveness to conduct critical research projects and corporate trials. Dr. Liao anticipates that her research will continue its success as many completed projects mature with results presented to and accepted by the international scientific community, and ongoing projects progress smoothly.
Present Title & Affiliation
Primary Appointment
Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Deputy Department Chair of Clinical Affairs, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Deputy Department Chair of Clinical Research, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1982 | Hunan Medical University, Changsha, CHN, MD, Medicine |
Postgraduate Training
| 2015-2015 | Executive Education Course:Strategy for Value-Based Healthcare Delivery, Strategy for Value-Based Healthcare Delivery, Rice University, Texas Medical Center, Houston, TX |
| 2015-2015 | Clinical Safety and Effectiveness Program, University of Texas MD Anderson Cancer Center, Houston, TX |
| 2012-2012 | Faculty Development, Beyond the CV: Behavioral Interviewing of Faculty Candidates, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2007-2008 | Faculty Leadership Academy, Faculty Leadership Academy, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 1995-1999 | Clinical Residency, Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 1994-1995 | Clinical Internship, Internal Medicine, The University of Kansas School of Medicine-Wichita, Wichita, KS |
| 1993-1994 | Clinical Fellowship, Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 1989-1993 | Research Fellowship, Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
Board Certifications
| 1999 | American Board of Radiology - Radiation Oncology |
Experience & Service
Administrative Appointments/Responsibilities
Medical Director, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2007 - 2016
Institutional Committee Activities
Member, Data Safety Monitoring Board, 2008 - 2010
Member, Harris County Health District (HCHD/MDACC) Joint Operation Committee, 2007 - 2010
Member, Uncompensated Care Advisory Committee, The University of Texas MD Anderson Cancer Center, 2007 - 2009
Member, The Executive Committee for Medical Staff, The University of Texas MD Anderson Cancer Center, 2007 - Present
Member, MDACC/HCHD Quarterly Administrative/Medical Advisory Committee, 2007 - 2009
Member, IRB Data Safety Monitoring Committee, The University of Texas MD Anderson Cancer Center, 2005 - 2008
Member, Steering Committee for China, Extramural Program, The University of Texas MD Anderson Cancer Center, 2004 - Present
Member, Asia Task Force, Extramural Program, The University of Texas MD Anderson Cancer Center, 1999 - Present
Honors & Awards
| 2011 | The Marie Sklodowska-Curie Award-American Association for Women Radiologists, American Association for Women Radiologists |
| 2007 | Outstanding International Collaboration Award, Chinese Society of Therapeutic Radiology and Oncology |
| 2007 | Outstanding Contribution to Radiation Oncology Education for China Award, Chinese Society of Therapeutic Radiology and Oncology |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Pasalic D, Betancourt-Cuellar SL, Taku N, Ludmir EB, Lu Y, Allen PK, Tang C, Antonoff MB, Fuller CD, Rosenthal DI, Morrison WH, Phan J, Garden AS, Welsh JW, Chang JY, Liao Z, Erasmus JJ, Nguyen QN. Outcomes and toxicities following stereotactic ablative radiotherapy for pulmonary metastases in patients with primary head and neck cancer. Head Neck 42(8):1939-1953, 2020. e-Pub 2020. PMID: 32129548.
- Liao Z, Rivin Del Campo E, Salem A, Pang Q, Liu H, Lopez Guerra JL. Optimizing lung cancer radiation treatment worldwide in COVID-19 outbreak. Lung Cancer 146:230-235, 2020. e-Pub 2020. PMID: 32585497.
- Rajaram R, Correa AM, Xu T, Nguyen QN, Antonoff MB, Rice D, Mehran R, Roth J, Walsh G, Swisher S, Hofstetter WL, Vaporciyan A, Cascone T, Tsao AS, Papadimitrakopoulou VA, Gandhi S, Liao Z, Sepesi B. Locoregional Control, Overall Survival, and Disease-Free Survival in Stage IIIA (N2) Non-Small-Cell Lung Cancer: Analysis of Resected and Unresected Patients. Clin Lung Cancer 21(4):e294-e301, 2020. e-Pub 2020. PMID: 32089476.
- Ning MS, McAleer MF, Jeter MD, Minsky BD, Ghafar RA, Robinson IJ, Nitsch PL, Zaebst DJ, Todd SE, Nguyen J, Lin SH, Liao Z, Lee P, Gunn GB, Klopp AH, Dabaja BS, Nguyen QN, Chronowski GM, Bloom ES, Koong AC, Das P. Mitigating the impact of COVID-19 on oncology: Clinical and operational lessons from a prospective radiation oncology cohort tested for COVID-19. Radiother Oncol 148:252-257, 2020. e-Pub 2020. PMID: 32474129.
- Noticewala SS, Koong AC, Bloom ES, Choi S, Chronowski G, Ghafar RA, Guadagnolo BA, Gunn GB, Klopp A, Lee P, Li J, Liao Z, Ludmir EB, McAleer MF, Nguyen QN, Ning MS, Robinson IJ, Rosenthal DI, Shah SJ, Woodward WA, Zaebst DJ, Dabaja BS, Das P. Radiation Oncology Strategies to Flatten the Curve During the Coronavirus Disease 2019 (COVID-19) Pandemic: Experience From a Large Tertiary Cancer Center. Adv Radiat Oncol 5(4):567-572, 2020. e-Pub 2020. PMID: 32775771.
- Xie F, Zhang J, Wang J, Reuben A, Xu W, Yi X, Varn FS, Ye Y, Cheng J, Yu M, Wang Y, Liu Y, Xie M, Du P, Ma K, Ma X, Zhou P, Yang S, Chen Y, Wang G, Xia X, Liao Z, Heymach JV, Wistuba II, Futreal PA, Ye K, Cheng C, Xia T. Multifactorial deep learning reveals pan-cancer genomic tumor clusters with distinct immunogenomic landscape and response to immunotherapy. Clin Cancer Res 26(12):2908-2920, 2020. e-Pub 2020. PMID: 31911545.
- Lin SH, Hobbs BP, Verma V, Tidwell RS, Smith GL, Lei X, Corsini EM, Mok I, Wei X, Yao L, Wang X, Komaki RU, Chang JY, Chun SG, Jeter MD, Swisher SG, Ajani JA, Blum-Murphy M, Vaporciyan AA, Mehran RJ, Koong AC, Gandhi SJ, Hofstetter WL, Hong TS, Delaney TF, Liao Z, Mohan R. Randomized Phase IIB Trial of Proton Beam Therapy Versus Intensity-Modulated Radiation Therapy for Locally Advanced Esophageal Cancer. J Clin Oncol 38(14):1569-1579, 2020. e-Pub 2020. PMID: 32160096.
- Wang Z, Chen M, Sun J, Jiang S, Wang L, Wang X, Sahoo N, Gunn GB, Frank SJ, Nguyen QN, Liao Z, Chang JY, Zhu XR, Zhang X. Lyman-Kutcher-Burman normal tissue complication probability modeling for radiation-induced esophagitis in non-small cell lung cancer patients receiving proton radiotherapy. Radiother Oncol 146:200-204, 2020. e-Pub 2020. PMID: 32220701.
- Chun SG, Liao Z, Jeter MD, Chang JY, Lin SH, Komaki RU, Guerrero TM, Mayo RC, Korah BM, Koshy SM, Heymach JV, Koong AC, Skinner HD. Metabolic Responses to Metformin in Inoperable Early-stage Non-Small Cell Lung Cancer Treated With Stereotactic Radiotherapy: Results of a Randomized Phase II Clinical Trial. Am J Clin Oncol 43(4):231-235, 2020. PMID: 31990759.
- Gjyshi O, Liao Z. Proton therapy for locally advanced non-small cell lung cancer. Br J Radiol 93(1107):20190378, 2020. e-Pub 2019. PMID: 31430188.
- Chen M, Yang J, Liao Z, Chen J, Xu C, He X, Zhang X, Zhu RX, Li H. Anatomic change over the course of treatment for non-small cell lung cancer patients and its impact on intensity-modulated radiation therapy and passive-scattering proton therapy deliveries. Radiat Oncol 15(1):55, 2020. e-Pub 2020. PMID: 32138753.
- Liu Y, Fan J, Xu T, Ahmadinejad N, Hess K, Lin SH, Zhang J, Liu X, Liu L, Ning B, Liao Z, Hu TY. Extracellular Vesicle Tetraspanin-8 Level Predicts Distant Metastasis in Non-Small Cell Lung Cancer after Concurrent Chemoradiation. Sci Adv 6(11):eaaz6162, 2020. e-Pub 2020. PMID: 32195353.
- Lin SH, Lin Y, Yao L, Kalhor N, Carter BW, Altan M, Blumenschein G, Byers LA, Fossella F, Gibbons DL, Kurie JM, Lu C, Simon G, Skoulidis F, Chang JY, Jeter MD, Liao Z, Gomez DR, O'Reilly M, Papadimitrakopoulou V, Thall P, Heymach JV, Tsao AS. Phase II Trial of Concurrent Atezolizumab With Chemoradiation for Unresectable NSCLC. J Thorac Oncol 15(2):248-257, 2020. e-Pub 2019. PMID: 31778797.
- Lei G, Zhang Y, Koppula P, Liu X, Zhang J, Lin SH, Ajani JA, Xiao Q, Liao Z, Wang H, Gan B. The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression. Cell Res 30(2):146-162, 2020. e-Pub 2020. PMID: 31949285.
- Wang XS, Shi Q, Mendoza T, Lin S, Chang JY, Bokhari RH, Lin HK, Garcia-Gonzalez A, Kamal M, Cleeland CS, Liao Z. Minocycline Reduces Chemoradiation-Related Symptom Burden in Patients with Non-small Cell Lung Cancer: A Phase II Randomized Trial. Int J Radiat Oncol Biol Phys 106(1):100-107, 2020. e-Pub 2019. PMID: 31627177.
- Palma G, Monti S, Xu T, Scifoni E, Yang P, Hahn SM, Durante M, Mohan R, Liao Z, Cella L. Spatial Dose Patterns Associated With Radiation Pneumonitis in a Randomized Trial Comparing Intensity-Modulated Photon Therapy With Passive Scattering Proton Therapy for Locally Advanced Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 104(5):1124-1132, 2019. e-Pub 2019. PMID: 30822531.
- Ludmir EB, Adlakha EK, Chun SG, Reed VK, Arzu IY, Ahmad N, Bloom E, Chronowski GM, Delclos ME, Mayo LL, Schlembach PJ, Liao Z, Koong AC, Herman JM, Shah SJ. Enhancing clinical trial enrollment at MD Anderson Cancer Center satellite community campuses. Acta Oncol 58(8):1135-1137, 2019. e-Pub 2019. PMID: 30958082.
- Elhammali A, Blanchard P, Yoder A, Liao Z, Zhang X, Ronald Zhu X, Allen PK, Jeter M, Welsh J, Nguyen QN. Clinical outcomes after intensity-modulated proton therapy with concurrent chemotherapy for inoperable non-small cell lung cancer. Radiother Oncol 136:136-142, 2019. e-Pub 2019. PMID: 31015115.
- Xu C, Guo L, Liao Z, Wang Y, Liu X, Zhao S, Wang J, Yuan Z, Wang P, Lin SH. Heart and lung doses are independent predictors of overall survival in esophageal cancer after chemoradiotherapy. Clin Transl Radiat Oncol 17:17-23, 2019. e-Pub 2019. PMID: 31080898.
- Yeboa DN, Liao Z, Court L, Holliday EB, Spelman A, Herman J. Protocol-in-a-Day Workshop: A Lean Approach to Clinical Trial Development and Focus on Junior Faculty Development. Adv Radiat Oncol 4(3):439-442, 2019. e-Pub 2019. PMID: 31360796.
- Ning MS, Gomez DR, Shah AK, Kim CR, Palmer MB, Thaker NG, Grosshans DR, Liao Z, Chapman BV, Brooks ED, Tang C, Rosenthal DI, Garden AS, Frank SJ, Gunn GB. The Insurance Approval Process for Proton Radiation Therapy: A Significant Barrier to Patient Care. Int J Radiat Oncol Biol Phys 104(4):724-733, 2019. e-Pub 2018. PMID: 30557675.
- Nguyen QN, Chun SG, Chow E, Komaki R, Liao Z, Zacharia R, Szeto BK, Welsh JW, Hahn SM, Fuller CD, Moon BS, Bird JE, Satcher R, Lin PP, Jeter M, O'Reilly MS, Lewis VO. Single-Fraction Stereotactic vs Conventional Multifraction Radiotherapy for Pain Relief in Patients With Predominantly Nonspine Bone Metastases: A Randomized Phase 2 Trial. JAMA Oncol 5(6):872-878, 2019. PMID: 31021390.
- Deng W, Xu C, Liu A, van Rossum PSN, Deng W, Liao Z, Koong AC, Mohan R, Lin SH. The relationship of lymphocyte recovery and prognosis of esophageal cancer patients with severe radiation-induced lymphopenia after chemoradiation therapy. Radiother Oncol 133:9-15, 2019. e-Pub 2019. PMID: 30935587.
- Milbury K, Liao Z, Shannon V, Mallaiah S, Nagarathna R, Li Y, Yang C, Carmack C, Bruera E, Cohen L. Dyadic yoga program for patients undergoing thoracic radiotherapy and their family caregivers: Results of a pilot randomized controlled trial. Psychooncology 28(3):615-621, 2019. e-Pub 2019. PMID: 30659739.
- Tucker SL, Xu T, Paganetti H, Deist T, Verma V, Choi N, Mohan R, Liao Z. Validation of Effective Dose as a Better Predictor of Radiation Pneumonitis Risk Than Mean Lung Dose: Secondary Analysis of a Randomized Trial. Int J Radiat Oncol Biol Phys 103(2):403-410, 2019. e-Pub 2018. PMID: 30291994.
- Krafft SP, Rao A, Stingo F, Briere TM, Court LE, Liao Z, Martel MK. Erratum: "The utility of quantitative CT radiomics features for improved prediction of radiation pneumonitis" [Med. Phys. Vol. 45(11):5317-5324 (2018)]. Med Phys 46(2):1079, 2019. e-Pub 2019. PMID: 30730574.
- Ge S, Wang X, Liao Z, Zhang L, Sahoo N, Yang J, Guan F, Mohan R. Potential for Improvements in Robustness and Optimality of Intensity-Modulated Proton Therapy for Lung Cancer with 4-Dimensional Robust Optimization. Cancers (Basel) 11(1), 2019. e-Pub 2019. PMID: 30609652.
- Yepes P, Adair A, Frank SJ, Grosshans DR, Liao Z, Liu A, Mirkovic D, Poenisch F, Titt U, Wang Q, Mohan R. Fixed- versus Variable-RBE Computations for Intensity Modulated Proton Therapy. Adv Radiat Oncol 4(1):156-167, 2019. e-Pub 2018. PMID: 30706024.
- Nong J, Gong Y, Guan Y, Yi X, Yi Y, Chang L, Yang L, Lv J, Guo Z, Jia H, Chu Y, Liu T, Chen M, Byers L, Roarty E, Lam VK, Papadimitrakopoulou VA, Wistuba I, Heymach JV, Glisson B, Liao Z, Lee JJ, Futreal PA, Zhang S, Xia X, Zhang J, Wang J. Author Correction: Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer. Nat Commun 10(1):552, 2019. e-Pub 2019. PMID: 30696827.
- Luo Y, Xu Y, Liao Z, Gomez D, Wang J, Jiang W, Zhou R, Williamson R, Court LE, Yang J. Automatic segmentation of cardiac substructures from noncontrast CT images: accurate enough for dosimetric analysis?. Acta Oncol 58(1):81-87, 2019. e-Pub 2018. PMID: 30306817.
- Yang P, Xu T, Gomez DR, Deng W, Wei X, Elhalawani H, Jin H, Guan F, Mirkovic D, Xu Y, Mohan R, Liao Z. Patterns of Local-Regional Failure After Intensity Modulated Radiation Therapy or Passive Scattering Proton Therapy With Concurrent Chemotherapy for Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 103(1):123-131, 2019. e-Pub 2018. PMID: 30165127.
- Deng W, Xu T, Xu Y, Wang Y, Liu X, Zhao Y, Yang P, Liao Z. Survival Patterns for Patients with Resected N2 Non-Small Cell Lung Cancer and Postoperative Radiotherapy: A Prognostic Scoring Model and Heat Map Approach. J Thorac Oncol 13(12):1968-1974, 2018. e-Pub 2018. PMID: 30194035.
- Krafft SP, Rao A, Stingo F, Briere TM, Court LE, Liao Z, Martel MK. The utility of quantitative CT radiomics features for improved prediction of radiation pneumonitis. Med Phys 45(11):5317-5324, 2018. e-Pub 2018. PMID: 30133809.
- Liao Z. Considerations in randomized trials to test technologies. J Thorac Dis 10(Suppl 26):S3308, 2018. PMID: 30370145.
- Deng W, Xu T, Wang Y, Xu Y, Yang P, Gomez D, Liao Z. Log odds of positive lymph nodes may predict survival benefit in patients with node-positive non-small cell lung cancer. Lung Cancer 122:60-66, 2018. e-Pub 2018. PMID: 30032846.
- Nong J, Gong Y, Guan Y, Yi X, Yi Y, Chang L, Yang L, Lv J, Guo Z, Jia H, Chu Y, Liu T, Chen M, Byers L, Roarty E, Lam VK, Papadimitrakopoulou VA, Wistuba I, Heymach JV, Glisson B, Liao Z, Lee JJ, Futreal PA, Zhang S, Xia X, Zhang J, Wang J. Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer. Nat Commun 9(1):3114, 2018. e-Pub 2018. PMID: 30082701.
- Brooks ED, Sun B, Feng L, Verma V, Zhao L, Gomez DR, Liao Z, Jeter M, O'Reilly M, Welsh JW, Nguyen QN, Erasmus JJ, Eapen G, Ahrar K, Antonoff MB, Hahn SM, Heymach JV, Rice DC, Chang JY. Association of Long-term Outcomes and Survival With Multidisciplinary Salvage Treatment for Local and Regional Recurrence After Stereotactic Ablative Radiotherapy for Early-Stage Lung Cancer. JAMA Netw Open 1(4):e181390, 2018. e-Pub 2018. PMID: 30646121.
- Sio TT, Prayongrat A, Zhang Y, Lin Q, Xu T, Liao Z, Yue J. The Road Less Traveled: Should We Omit Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer?. Clin Lung Cancer 19(4):289-293, 2018. e-Pub 2018. PMID: 29665993.
- Nantavithya C, Gomez DR, Wei X, Komaki R, Liao Z, Lin SH, Jeter M, Nguyen QN, Li H, Zhang X, Poenisch F, Zhu XR, Balter PA, Feng L, Choi NC, Mohan R, Chang JY. Phase 2 Study of Stereotactic Body Radiation Therapy and Stereotactic Body Proton Therapy for High-Risk, Medically Inoperable, Early-Stage Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 101(3):558-563, 2018. e-Pub 2018. PMID: 29680255.
- Liao Z, Mohan R. Reply to R. Rengan et al. J Clin Oncol 36(19):2004-2005, 2018. e-Pub 2018. PMID: 29746223.
- Liao Z, Mohan R. Future of Protons Depends on Precision. J Clin Oncol 36(19):2002, 2018. e-Pub 2018. PMID: 29746224.
- Boonyawan K, Gomez DR, Komaki R, Xu Y, Nantavithya C, Allen PK, Mohan R, Liao Z. Clinical and Dosimetric Factors Predicting Grade =2 Radiation Pneumonitis After Postoperative Radiotherapy for Patients With Non-Small Cell Lung Carcinoma. Int J Radiat Oncol Biol Phys 101(4):919-926, 2018. e-Pub 2018. PMID: 29976504.
- Yang J, Xu T, Gomez DR, Yuan X, Nguyen QN, Jeter M, Song Y, Komaki R, Hu Y, Hahn SM, Liao Z. Nomograms incorporating genetic variants in BMP/Smad4/Hamp pathway to predict disease outcomes after definitive radiotherapy for non-small cell lung cancer. Cancer Med 7(6):2247-2255, 2018. e-Pub 2018. PMID: 29745043.
- Jiang XE, Xu T, Wei Q, Li P, Gomez DR, Court LE, Liao Z. DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non-small-cell lung cancer. Chronic Dis Transl Med 4(2):109-116, 2018. e-Pub 2018. PMID: 29988954.
- Zhang Y, Lin Q, Xu T, Deng W, Yu J, Liao Z, Yue J. Out of the darkness and into the light: New strategies for improving treatments for locally advanced non-small cell lung cancer. Cancer Lett 421:59-62, 2018. e-Pub 2018. PMID: 29425685.
- Liao Z, Gandhi SJ, Lin SH, Bradley J. Does Proton Therapy Offer Demonstrable Clinical Advantages for Treating Thoracic Tumors?. Semin Radiat Oncol 28(2):114-124, 2018. PMID: 29735187.
- Liao Z, Simone CB. Particle therapy in non-small cell lung cancer. Transl Lung Cancer Res 7(2):141-152, 2018. PMID: 29876313.
- Jeter MD, Gomez D, Nguyen QN, Komaki R, Zhang X, Zhu X, O'Reilly M, Fossella FV, Xu T, Wei X, Wang H, Yang W, Tsao A, Mohan R, Liao Z. Simultaneous Integrated Boost for Radiation Dose Escalation to the Gross Tumor Volume With Intensity Modulated (Photon) Radiation Therapy or Intensity Modulated Proton Therapy and Concurrent Chemotherapy for Stage II to III Non-Small Cell Lung Cancer: A Phase 1 Study. Int J Radiat Oncol Biol Phys 100(3):730-737, 2018. e-Pub 2017. PMID: 29248169.
- Milbury K, Engle R, Tsao A, Liao Z, Owens A, Chaoul A, Bruera E, Cohen L. Pilot Testing of a Brief Couple-Based Mind-Body Intervention for Patients with Metastatic Non-Small Cell Lung Cancer and Their Partners. J Pain Symptom Manage 55(3):953-961, 2018. e-Pub 2017. PMID: 29208478.
- Lopez Guerra JL, Song YP, Nguyen QN, Gomez DR, Liao Z, Xu T. Functional promoter rs189037 variant of ATM is associated with decrease in lung diffusing capacity after irradiation for non-small-cell lung cancer. Chronic Dis Transl Med 4(1):59-66, 2018. e-Pub 2018. PMID: 29756124.
- Zhou R, Xu T, Nguyen QN, Liu Y, Yang J, Komaki R, Gomez DR, Liao Z. Radiation Dose, Local Disease Progression, and Overall Survival in Patients With Inoperable Non-Small Cell Lung Cancer After Concurrent Chemoradiation Therapy. Int J Radiat Oncol Biol Phys 100(2):452-461, 2018. e-Pub 2017. PMID: 29174428.
- Ho JC, Nguyen QN, Li H, Allen PK, Zhang X, Liao Z, Zhu XR, Gomez D, Lin SH, Gillin M, Komaki R, Hahn S, Chang JY. Reirradiation of thoracic cancers with intensity modulated proton therapy. Pract Radiat Oncol 8(1):58-65, 2018. e-Pub 2017. PMID: 28867546.
- Hong J, Liao Z, Zhuang Y, Levy LB, Sheu T, Heymach JV, Nguyen QN, Xu T, Komaki R, Gomez DR. Prognostic Factors as a Function of Disease-free Interval After Definitive (Chemo)radiation for Non-Small Cell Lung Cancer Using Conditional Survival Analysis. Am J Clin Oncol 41(1):46-52, 2018. PMID: 26535988.
- Milbury K, Tsao AS, Liao Z, Owns A, Engle R, Gonzalez EA, Bruera E, Cohen L. A research protocol for a pilot randomized controlled trial designed to examine the feasibility of a couple-based mind-body intervention for patients with metastatic lung cancer and their partners. Pilot Feasibility Stud 4:37, 2018. e-Pub 2018. PMID: 29416870.
- Tang C, Lee MS, Gomez D, Levy LB, Zhuang Y, Lu C, Liao Z, Komaki R. Effects of Chemotherapy Regimen and Radiation Modality on Hematologic Toxicities in Patients Receiving Definitive Platinum-based Doublet Chemoradiation for Non-Small Cell Lung Cancer. Am J Clin Oncol 40(6):625-630, 2017. PMID: 26165417.
- De Ruysscher D, Jin J, Lautenschlaeger T, She JX, Liao Z, Kong FS. Blood-based biomarkers for precision medicine in lung cancer: precision radiation therapy. Transl Lung Cancer Res 6(6):661-669, 2017. PMID: 29218269.
- Xi M, Liao Z, Hofstetter WL, Komaki R, Ho L, Lin SH. FDG-PET Response After Induction Chemotherapy Can Predict Who Will Benefit From Subsequent Esophagectomy After Chemoradiotherapy for Esophageal Adenocarcinoma. J Nucl Med 58(11):1756-1763, 2017. e-Pub 2017. PMID: 28522744.
- Blum Murphy M, Xiao L, Patel VR, Maru DM, Correa AM, G Amlashi F, Liao Z, Komaki R, Lin SH, Skinner HD, Vaporciyan A, Walsh GL, Swisher SG, Sepesi B, Lee JH, Bhutani MS, Weston B, Hofstetter WL, Ajani JA. Pathological complete response in patients with esophageal cancer after the trimodality approach: The association with baseline variables and survival-The University of Texas MD Anderson Cancer Center experience. Cancer 123(21):4106-4113, 2017. e-Pub 2017. PMID: 28885712.
- Pezzi TA, Tang C, Swanick CW, Fang P, Hess K, Xu T, Hahn SM, Chang JY, Liao Z, Gomez D. Patterns and correlates of treatment failure in relation to isodose distribution in non-small cell lung cancer: An analysis of 1522 patients in the modern era. Radiother Oncol 125(2):325-330, 2017. e-Pub 2017. PMID: 29054376.
- Xu Y, Deng W, Yang S, Li P, Kong Y, Tian Y, Liao Z, Chen M. Dosimetric comparison of the helical tomotherapy, volumetric-modulated arc therapy and fixed-field intensity-modulated radiotherapy for stage IIB-IIIB non-small cell lung cancer. Sci Rep 7(1):14863, 2017. e-Pub 2017. PMID: 29093491.
- Xi M, Xu C, Liao Z, Chang JY, Gomez DR, Jeter M, Cox JD, Komaki R, Mehran R, Blum MA, Hofstetter WL, Maru DM, Bhutani MS, Lee JH, Weston B, Ajani JA, Lin SH. Comparative Outcomes After Definitive Chemoradiotherapy Using Proton Beam Therapy Versus Intensity Modulated Radiation Therapy for Esophageal Cancer: A Retrospective, Single-Institutional Analysis. Int J Radiat Oncol Biol Phys 99(3):667-676, 2017. e-Pub 2017. PMID: 29280461.
- Yang J, Haas B, Fang R, Beadle BM, Garden AS, Liao Z, Zhang L, Balter P, Court L. Atlas ranking and selection for automatic segmentation of the esophagus from CT scans. Phys Med Biol 62(23):9140-9158, 2017. e-Pub 2017. PMID: 29049027.
- Niedzielski JS, Yang J, Mohan R, Titt U, Mirkovic D, Stingo F, Liao Z, Gomez DR, Martel MK, Briere TM, Court LE. Differences in Normal Tissue Response in the Esophagus Between Proton and Photon Radiation Therapy for Non-Small Cell Lung Cancer Using In Vivo Imaging Biomarkers. Int J Radiat Oncol Biol Phys 99(4):1013-1020, 2017. e-Pub 2017. PMID: 29063837.
- Xi M, Liao Z, Deng W, Komaki R, Ho L, Lin SH. Recursive Partitioning Analysis Identifies Pretreatment Risk Groups for the Utility of Induction Chemotherapy Before Definitive Chemoradiation Therapy in Esophageal Cancer. Int J Radiat Oncol Biol Phys 99(2):407-416, 2017. e-Pub 2017. PMID: 28871991.
- Adams DL, Adams DK, He J, Kalhor N, Zhang M, Xu T, Gao H, Reuben JM, Qiao Y, Komaki R, Liao Z, Edelman MJ, Tang CM, Lin SH. Sequential Tracking of PD-L1 Expression and RAD50 Induction in Circulating Tumor and Stromal Cells of Lung Cancer Patients Undergoing Radiotherapy. Clin Cancer Res 23(19):5948-5958, 2017. e-Pub 2017. PMID: 28679765.
- Ning MS, Tang L, Gomez DR, Xu T, Luo Y, Huo J, Mouhayar E, Liao Z. Incidence and Predictors of Pericardial Effusion After Chemoradiation Therapy for Locally Advanced Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 99(1):70-79, 2017. e-Pub 2017. PMID: 28816165.
- Xi M, Xu C, Liao Z, Hofstetter WL, Blum Murphy M, Maru DM, Bhutani MS, Lee JH, Weston B, Komaki R, Lin SH.. The impact of histology on recurrence patterns in esophageal cancer treated with definitive chemoradiotherapy. Radiother Oncol 124(2):318-324, 2017. e-Pub 2017. PMID: 28687396.
- Milbury K, Kavanagh A, Meng Z, Chen Z, Chandwani KD, Garcia K, Perkins GH, McQuade J, Raghuram NV, Nagarathna R, Liao Z, Nagendra HR, Chen J, Guo X, Liu L, Arun B, Cohen L. Depressive symptoms and positive affect in Chinese and United States breast cancer survivors: a cross-cultural comparison. Support Care Cancer 25(7):2103-2109, 2017. e-Pub 2017. PMID: 28233122.
- Brooks ED, Sun B, Zhao L, Komaki R, Liao Z, Jeter M, Welsh JW, O'Reilly MS, Gomez DR, Hahn SM, Heymach JV, Rice DC, Chang JY. Stereotactic Ablative Radiation Therapy is Highly Safe and Effective for Elderly Patients With Early-stage Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 98(4):900-907, 2017. e-Pub 2016. PMID: 28258887.
- Lester SC, Lin SH, Chuong M, Bhooshan N, Liao Z, Arnett AL, James SE, Evans JD, Spears GM, Komaki R, Haddock MG, Mehta MP, Hallemeier CL, Merrell KW.. A Multi-institutional Analysis of Trimodality Therapy for Esophageal Cancer in Elderly Patients. Int J Radiat Oncol Biol Phys 98(4):820-828, 2017. e-Pub 2017. PMID: 28476435.
- Joshua S. Niedzielski, Jinzhong Yang,Francesco Stingo, Liao Z ,Daniel Gomez, Radhe Mohan, Mary Martel, Tina Briere, and Laurence Court. A Novel Methodology using CT Imaging Biomarkers to Quantify Radiation Sensitivity in the Esophagus with Application to Clinical Trials. Scientific Reports 7(1):6034, 2017. PMID: PMC5519548.
- Lin SH, Merrell KW, Shen J, Verma V, Correa AM, Wang L, Thall PF, Bhooshan N, James SE, Haddock MG, Suntharalingam M, Mehta MP, Liao Z, Cox JD, Komaki R, Mehran RJ, Chuong MD, Hallemeier CL.. Multi-institutional analysis of radiation modality use and postoperative outcomes of neoadjuvant chemoradiation for esophageal cancer. Radiother Oncol 123(3):376-381, 2017. e-Pub 2017. PMID: 28455153.
- Xi M, Hallemeier CL, Merrell KW, Liao Z, Murphy MAB, Ho L, Hofstetter WL, Mehran R, Lee JH, Bhutani MS, Weston B, Maru DM, Komaki R, Ajani JA, Lin SH.. Recurrence Risk Stratification After Preoperative Chemoradiation of Esophageal Adenocarcinoma. Ann Surg, 2017. e-Pub 2017. PMID: 28628563.
- Yang J, Xu T, Gomez DR, Yuan X, Nguyen QN, Jeter M, Song Y, Hahn S, Liao Z. Polymorphisms in BMP2/BMP4, with estimates of mean lung dose, predict radiation pneumonitis among patients receiving definitive radiotherapy for non-small cell lung cancer. Oncotarget 8(26):43080-43090, 2017. PMID: 28574846.
- Chi A, Chen H, Wen S, Yan H, Liao Z.. Comparison of particle beam therapy and stereotactic body radiotherapy for early stage non-small cell lung cancer: A systematic review and hypothesis-generating meta-analysis. Radiother Oncol 123(3):346-354, 2017. PMID: 28545956.
- Ho JC, Nguyen QN, Li H, Allen PK, Zhang X, Zhu XR, Gomez DR, Lin SH, Gillin MT, Komaki RU, Liao Z, Hahn SM, Chang JY. Reirradiation of Thoracic Cancers with Intensity Modulated Proton Therapy. Int J Radiat Oncol Biol Phys 98(1):222, 2017. PMID: 28586972.
- Nguyen QN, Lu Y, Tang C, Chance WW, Mehran R, Balter P, Welsh JW, Hahn SM, Jeter MD, Komaki RU, Gomez DR, Chang JY, Liao Z. Stereotactic Ablative Body Radiation for Pulmonary Metastases: Should We Consider Dose Escalation for More Unresponsive Histologies?. Int J Radiat Oncol Biol Phys 98(1):237, 2017. PMID: 28587012.
- Fave X, Zhang L, Yang J, Mackin D, Balter P, Gomez DR, Followill D, Jones AK, Stingo F, Mohan R, Liao Z, Court LE. Using Pretreatment Radiomics and Delta-Radiomics Features to Predict Non-Small Cell Lung Cancer Patient Outcomes. Int J Radiat Oncol Biol Phys 98(1):249, 2017. PMID: 28587041.
- Yang J, Xu T, Gomez DR, Jeter M, Levy LB, Song Y, Hahn S, Liao Z, Yuan X. The Pulmonary Fibrosis Associated MUC5B Promoter Polymorphism Is Prognostic of the Overall Survival in Patients with Non-Small Cell Lung Cancer (NSCLC) Receiving Definitive Radiotherapy. Transl Oncol 10(2):197-202, 2017. e-Pub 2017. PMID: 28189065.
- Fave X, Zhang L, Yang J, Mackin D, Balter P, Gomez D, Followill D, Jones AK, Stingo F, Liao Z, Mohan R, Court L. Delta-radiomics features for the prediction of patient outcomes in non-small cell lung cancer. Sci Rep 7(1):588, 2017. e-Pub 2017. PMID: 28373718.
- Logan JK, Tang C, Liao Z, Lee JJ, Heymach JV, Swisher SG, Welsh JW, Zhang J, Lin SH, Gomez DR. Analysis of Factors Affecting Successful Clinical Trial Enrollment in the Context of Three Prospective, Randomized, Controlled Trials. Int J Radiat Oncol Biol Phys 97(4):770-777, 2017. e-Pub 2016. PMID: 28244413.
- Chun SG, Solberg TD, Grosshans DR, Nguyen QN, Simone CB, Mohan R, Liao Z, Hahn SM, Herman JM, Frank SJ. The Potential of Heavy-Ion Therapy to Improve Outcomes for Locally Advanced Non-Small Cell Lung Cancer. Front Oncol 7:201, 2017. e-Pub 2017. PMID: 28929085.
- Wang J, Suri JS, Allen PK, Liao Z, Komaki R, Ho L, Hofstetter WL, Lin SH. Factors predictive of improved outcomes with multimodality local therapy after palliative chemotherapy for stage iv esophageal cancer. Am J Clin Oncol 39(3):228-35, 2016. e-Pub 2014. PMID: 24710122.
- Wang XS, Shi Q, Williams LA, Komaki R, Gomez DR, Lin SH, Chang JY, O'Reilly MS, Bokhari RH, Cox JD, Mohan R, Cleeland CS, Liao Z. Prospective study of patient-reported symptom burden in patients with non-small-cell lung cancer undergoing proton or photon chemoradiation therapy. J Pain Symptom Manage 51(5):832-8, 2016. e-Pub 2016. PMID: 26891607.
- Lin SH, Zhang N, Godby J, Wang J, Marsh GD, Liao Z, Komaki R, Ho L, Hofstetter WL, Swisher SG, Mehran RJ, Buchholz TA, Elting LS, Giordano SH. Radiation modality use and cardiopulmonary mortality risk in elderly patients with esophageal cancer. Cancer 122(6):917-28, 2016. e-Pub 2015. PMID: 26716915.
- Fried DV, Mawlawi O, Zhang L, Fave X, Zhou S, Ibbott G, Liao Z, Court LE. Stage III non-small cell lung cancer: prognostic value of FDG PET quantitative imaging features combined with clinical prognostic factors. Radiology 278(1):377-84, 2016. e-Pub 2015. PMID: 26176655.
- Pan HY, Jiang S, Sutton J, Liao Z, Chance WW, Frank SJ, Zhu XR, Li H, Fontanilla HP, Zhang X, Gomez DR. Early experience with intensity modulated proton therapy for lung-intact mesothelioma: a case series. Pract Radiat Oncol 5(4):e345-53, 2015. e-Pub 2015. PMID: 25572666.
- Liu W, Liao Z, Schild SE, Liu Z, Li H, Li Y, Park PC, Li X, Stoker J, Shen J, Keole S, Anand A, Fatyga M, Dong L, Sahoo N, Vora S, Wong W, Zhu XR, Bues M, Mohan R. Impact of respiratory motion on worst-case scenario optimized intensity modulated proton therapy for lung cancers. Pract Radiat Oncol 5(2):e77-86, 2015. e-Pub 2014. PMID: 25413400.
- Swanick CW, Lin SH, Sutton J, Naik NS, Allen PK, Levy LB, Liao Z, Welsh JW, Komaki R, Chang JY, Gomez DR. Use of simultaneous radiation boost achieves high control rates in patients with non-small-cell lung cancer who are not candidates for surgery or conventional chemoradiation. Clin Lung Cancer 16(2):156-163, 2015. e-Pub 2014. PMID: 25467928.
- Wang H, Liao Z, Zhuang Y, Liu Y, Levy LB, Xu T, Yusuf SW, Gomez DR. Incidental receipt of cardiac medications and survival outcomes among patients with stage III non-small-cell lung cancer after definitive radiotherapy. Clin Lung Cancer 16(2):128-136, 2015. e-Pub 2014. PMID: 25450873.
- Li H, Zhang X, Park P, Liu W, Chang J, Liao Z, Frank S, Li Y, Poenisch F, Mohan R, Gillin M, Zhu R. Robust optimization in intensity-modulated proton therapy to account for anatomy changes in lung cancer patients. Radiother Oncol 114(3):367-72, 2015. e-Pub 2015. PMID: 25708992.
- Wang J, Milton DR, He L, Komaki R, Liao Z, Crane CH, Minsky BD, Thall PF, Lin SH. Comparison of locoregional versus extended locoregional radiation volumes for patients with nonmetastatic gastro-esophageal junction carcinomas. J Thorac Oncol 10(3):518-26, 2015. PMID: 25695222.
- Lin SH, Wang J, Allen PK, Correa AM, Maru DM, Swisher SG, Hofstetter WL, Liao Z, Ajani JA. A nomogram that predicts pathologic complete response to neoadjuvant chemoradiation also predicts survival outcomes after definitive chemoradiation for esophageal cancer. J Gastrointest Oncol 6(1):45-52, 2015. PMID: 25642337.
- Chance WW, Rice DC, Allen PK, Tsao AS, Fontanilla HP, Liao Z, Chang JY, Tang C, Pan HY, Welsh JW, Mehran RJ, Gomez DR. Hemithoracic intensity modulated radiation therapy after pleurectomy/decortication for malignant pleural mesothelioma: toxicity, patterns of failure, and a matched survival analysis. Int J Radiat Oncol Biol Phys 91(1):149-56, 2015. e-Pub 2014. PMID: 25442335.
- Xu T, Liao Z, O'Reilly MS, Levy LB, Welsh JW, Wang LE, Lin SH, Komaki R, Liu Z, Wei Q, Gomez DR. Serum inflammatory miRNAs predict radiation esophagitis in patients receiving definitive radiochemotherapy for non-small cell lung cancer. Radiother Oncol 113(3):379-84, 2014. e-Pub 2014. PMID: 25466375.
- Sheu T, Heymach JV, Swisher SG, Rao G, Weinberg JS, Mehran R, McAleer MF, Liao Z, Aloia TA, Gomez DR. Propensity score-matched analysis of comprehensive local therapy for oligometastatic non-small cell lung cancer that did not progress after front-line chemotherapy. Int J Radiat Oncol Biol Phys 90(4):850-857, 2014. e-Pub 2014. PMID: 25216859.
- Fried DV, Tucker SL, Zhou S, Liao Z, Mawlawi O, Ibbott G, Court LE. Prognostic value and reproducibility of pretreatment CT texture features in stage iii non-small cell lung cancer. Int J Radiat Oncol Biol Phys 90(4):834-842, 2014. e-Pub 2014. PMID: 25220716.
- McAvoy S, Ciura K, Wei C, Rineer J, Liao Z, Chang JY, Palmer MB, Cox JD, Komaki R, Gomez DR. Definitive reirradiation for locoregionally recurrent non-small cell lung cancer with proton beam therapy or intensity modulated radiation therapy: predictors of high-grade toxicity and survival outcomes. Int J Radiat Oncol Biol Phys 90(4):819-827, 2014. e-Pub 2014. PMID: 25220718.
- Chang JY, Li H, Zhu XR, Liao Z, Zhao L, Liu A, Li Y, Sahoo N, Poenisch F, Gomez DR, Wu R, Gillin M, Zhang X. Clinical implementation of intensity modulated proton therapy for thoracic malignancies. Int J Radiat Oncol Biol Phys 90(4):809-818, 2014. e-Pub 2014. PMID: 25260491.
- Kardar L, Li Y, Li X, Li H, Cao W, Chang JY, Liao Z, Zhu RX, Sahoo N, Gillin M, Liao Z, Komaki R, Cox JD, Lim G, Zhang X. Evaluation and mitigation of the interplay effects of intensity modulated proton therapy for lung cancer in a clinical setting. Pract Radiat Oncol 4(6):E259-268, 2014. e-Pub 2014. PMID: 25407877.
- Gomez DR, Yusuf SW, Munsell MF, Welsh JW, Liao Z, Lin SH, Pan HY, Chang JY, Komaki R, Cox JD, McAleer MF, Grosshans DR. Prospective exploratory analysis of cardiac biomarkers and electrocardiogram abnormalities in patients receiving thoracic radiation therapy with high-dose heart exposure. J Thorac Oncol 9(10):1554-1560, 2014. PMID: 25521400.
- He L, Allen PK, Potter A, Wang J, Chang JY, Gomez DR, Komaki R, Liao Z, Lin SH. Re-evaluating the optimal radiation dose for definitive chemoradiotherapy for esophageal squamous cell carcinoma. J Thorac Oncol 9(9):1398-1405, 2014. PMID: 25122435.
- Tang C, Liao Z, Gomez D, Levy L, Zhuang Y, Gebremichael RA, Hong DS, Komaki R, Welsh JW. Lymphopenia association with gross tumor volume and lung V5 and its effects on non-small cell lung cancer patient outcomes. Int J Radiat Oncol Biol Phys 89(5):1084-1091, 2014. e-Pub 2014. PMID: 25035212.
- Wen J, Liu H, Wang Q, Liu Z, Li Y, Xiong H, Xu T, Li P, Wang LE, Gomez DR, Mohan R, Komaki R, Liao Z, Wei Q. Genetic variants of the Lin28b gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. Eur J Cancer 50(10):1706-1716, 2014. e-Pub 2014. PMID: 24780874.
- Mayr NA, Hu KS, Liao Z, Viswanathan AN, Wall TJ, Amendola BE, Calaguas MJ, Palta JR, Yue NJ, Rengan R, Williams TR. International outreach: what is the responsibility of astro and the major international radiation oncology societies?. Int J Radiat Oncol Biol Phys 89(3):481-484, 2014. PMID: 24929158.
- Rosenstein BS, West CM, Bentzen SM, Alsner J, Andreassen CN, Azria D, Barnett GC, Baumann M, Burnet N, Chang-Claude J, Chuang EY, Coles CE, Dekker A, De Ruyck K, De Ruysscher D, Drumea K, Dunning AM, Easton D, Eeles R, Fachal L, Gutiérrez-Enríquez S, Haustermans K, Henríquez-Hernández LA, Imai T, Jones GD, Kerns SL, Liao Z, Onel K, Ostrer H, Parliament M, Pharoah PD, Rebbeck TR, Talbot CJ, Thierens H, Vega A, Witte JS, Wong P, Zenhausern F, Radiogenomics Consortium. Radiogenomics: radiobiology enters the era of big data and team science. Int J Radiat Oncol Biol Phys 89(4):709-713, 2014. PMID: 24969789.
- Tucker SL, Liao Z, Dinh J, Bian SX, Mohan R, Martel MK, Grosshans DR. Is there an impact of heart exposure on the incidence of radiation pneumonitis? Analysis of data from a large clinical cohort. Acta Oncol 53(5):590-596, 2014. e-Pub 2013. PMID: 23992110.
- Chaoul A, Milbury K, Engle R, Liao Z, Yang C, Carmack C, Shannon V, Spelman A, Wangyal T, Cohen L. Tibetan yoga can help people with lung cancer and their caregivers. J Altern Complement Med 20(5):A52, 2014. PMID: 24805634.
- Juloori A, Tucker SL, Komaki R, Liao Z, Correa AM, Swisher SG, Hofstetter WL, Lin SH. Influence of preoperative radiation field on postoperative leak rates in esophageal cancer patients after trimodality therapy. J Thorac Oncol 9(4):534-540, 2014. PMID: 24736077.
- Tang C, Liao Z, Zhuang Y, Levy LB, Hung C, Li X, Krafft SP, Martel MK, Komaki R, Gomez DR. Acute phase response before treatment predicts radiation esophagitis in non-small cell lung cancer. Radiother Oncol 110(3):493-498, 2014. e-Pub 2014. PMID: 24560756.
- Wang J, Myles B, Wei C, Chang JY, Hofstetter WL, Ajani JA, Swisher SG, Cox JD, Komaki R, Liao Z, Lin SH. Obesity and outcomes in patients treated with chemoradiotherapy for esophageal carcinoma. Dis Esophagus 27(2):168-175, 2014. e-Pub 2013. PMID: 23621168.
- Tang C, Gomez DR, Wang H, Levy LB, Zhuang Y, Xu T, Nguyen Q, Komaki R, Liao Z. Association between white blood cell count following radiation therapy with radiation pneumonitis in non-small cell lung cancer. Int J Radiat Oncol Biol Phys 88(2):319-325, 2014. PMID: 24411603.
- Li Y, Kardar L, Li X, Li H, Cao W, Chang JY, Liao Z, Zhu RX, Sahoo N, Gillin M, Liao Z, Komaki R, Cox JD, Lim G, Zhang X. On the interplay effects with proton scanning beams in stage III lung cancer. Med Phys 41(2):021721, 2014. PMID: 24506612.
- Amini A, Ajani J, Komaki R, Allen PK, Minsky BD, Blum M, Xiao L, Suzuki A, Hofstetter W, Swisher S, Gomez D, Liao Z, Lee JH, Bhutani MS, Welsh JW. Factors associated with local-regional failure after definitive chemoradiation for locally advanced esophageal cancer. Ann Surg Oncol 21(1):306-314, 2014. e-Pub 2013. PMID: 24197760.
- Hellmann MD, Chaft JE, William WN, Rusch V, Pisters KM, Kalhor N, Pataer A, Travis WD, Swisher SG, Kris MG, Liao Z, University of Texas MD Anderson Lung Cancer Collaborative Group. Pathological response after neoadjuvant chemotherapy in resectable non-small-cell lung cancers: proposal for the use of major pathological response as a surrogate endpoint. Lancet Oncol 15(1):e42-50, 2014. PMID: 24384493.
- Chi A, Wen S, Liao Z, Fowler J, Xu J, Nguyen NP, Welsh JS, Komaki R. What would be the most appropriate α/β ratio in the setting of stereotactic body radiation therapy for early stage non-small cell lung cancer. Biomed Res Int 2013:391021, 2013. e-Pub 2013. PMID: 24350266.
- Li Q, Swanick CW, Allen PK, Gomez DR, Welsh JW, Liao Z, Balter PA, Chang JY. Stereotactic ablative radiotherapy (SABR) using 70gy in 10 fractions for non-small cell lung cancer: exploration of clinical indications. Radiother Oncol. e-Pub 2014. PMID: 25108807.
- Sun B, Brooks ED, Komaki RU, Liao Z, Jeter MD, McAleer MF, Allen PK, Balter PA, Welsh JD, O'Reilly MS, Gomez D, Hahn SM, Roth JA, Mehran RJ, Heymach JV, Chang JY.. 7-year follow-up after stereotactic ablative radiotherapy for patients with stage I non-small cell lung cancer: Results of a phase 2 clinical trial. Cancer 123(16):3031-3039. e-Pub 2017. PMID: 28346656.
- Yue J, McKeever M, Sio TT, XUT, Huo J, Shi Q, Nguyen QN, Komaki R, Gomez DR, Pan T, Wang XS, Liao Z. Association of lung fluorodeoxyglucose uptake with radiation pneumonitis after concurrent chemoradiation for non-small cell lung cancer. Clin Transl Radiat Oncol. e-Pub 2017.
- Fang P, Swanick CW, Pezzi TA, Liao Z, Welsh J, Lin SH, Gomez DR. Outcomes and toxicity following high-dose radiation therapy in 15 fractions for non-small cell lung cancer. Pract Radiat Oncol. e-Pub 2017. PMID: 28428017.
- Xi M, Liao Z, Deng W, Xu C, Komaki R, Blum M, Hofstetter WL, Ho L, Lin SH. A Prognostic Scoring Model for the Utility of Induction Chemotherapy Prior to Neoadjuvant Chemoradiotherapy in Esophageal Cancer. J Thorac Oncol. e-Pub 2017. PMID: 28351804.
- Sun B, Brooks ED, Komaki R, Liao Z, Jeter M, McAleer M, Balter PA, Welsh JD, O'Reilly M, Gomez D, Hahn SM, Sepesi B, Rice DC, Heymach JV, Chang JY. Long-Term Outcomes of Salvage Stereotactic Ablation Radiotherapy for Isolated Lung Recurrence of Non-Small-Cell Lung Cancer: A Phase II Clinical Trial. J Thorac Oncol. e-Pub 2017. PMID: 28259750.
- Chang JY, Verma V, Li M, Zhang W, Komaki R, Lu C, Allen PK, Liao Z, Welsh J, Lin SH, Gomez D, Jeter M, O'Reilly M, Zhu RX, Zhang X, Li H1, Mohan R, Heymach JV, Vaporciyan AA, Hahn S, Cox JD. Proton Beam Radiotherapy and Concurrent Chemotherapy for Unresectable Stage III Non-Small Cell Lung Cancer: Final Results of a Phase 2 Study. JAMA Oncol 3(8). e-Pub 2017. PMID: 28727865.
- Jensen GL, Tang C, Hess KR, Liao Z, Gomez DR. Patterns of metastatic progression after definitive radiation therapy for early-stage and locally advanced non-small cell lung cancer. Clin Exp Metastasis. e-Pub 2017. PMID: 28744603.
- Sun B, Brooks ED, Komaki R, Liao Z, Jeter M, McAleer M, Balter PA, Welsh JD, O'Reilly M, Gomez D, Hahn SM, Sepesi B, Rice DC, Heymach JV, Chang JY.. Long-Term Outcomes of Salvage Stereotactic Ablative Radiotherapy for Isolated Lung Recurrence of Non-Small Cell Lung Cancer: A Phase II Clinical Trial. J Thorac Oncol 12(6):983-92. e-Pub 2017. PMID: 28259750.
- Yue J, Shi Q, Xu T, Jeter M, Chen TY, Komaki R, Gomez DR, Pan T, Cleeland CS, Liao Z, Wang XS. Patient-reported lung symptoms as an early signal of impending radiation pneumonitis in patients with non-small cell lung cancer treated with chemoradiation: an observational study. Qual Life Res. e-Pub 2018. PMID: 29549533.
- Wen J, Liu H, Wang L, Wang X, Gu N, Liu Z, Xu T, Gomez DR, Komaki R, Liao Z, Wei Q. Potentially Functional variants of ATG16L2 predict radiation pneumonitis and outcomes in patients with non-small cell lung cancer after definitive radiotherapy. J Thorac Oncol. e-Pub 2018. PMID: 29454863.
- Liu C, Schild SE, Chang JY, Liao Z, Korte S, Shen J, Ding X, Hu Y, Kang Y, Keole SR, Sio TT, Wong WW, Sahoo N, Bues M, Liu W. Impact of Spot Size and Spacing on the Quality of Robustly Optimized Intensity Modulated Proton Therapy Plans for Lung Cancer. Int J Radiat Oncol Biol Phys. e-Pub 2018. PMID: 29550033.
- Shusharina N, Liao Z, Mohan R, Liu A, Niemierko A, Choi N, Bortfeld T. Differences in lung injury after IMRT or proton therapy assessed by 18FDG PET imaging. Radiother Oncol. e-Pub 2018. PMID: 29352608.
- Liao Z, Lee JJ, Komaki R, Gomez DR, O'Reilly MS, Fossella FV, Blumenschein GR, Heymach JV, Vaporciyan AA, Swisher SG, Allen PK, Choi NC, DeLaney TF, Hahn SM, Cox JD, Lu CS, Mohan R. Bayesian Adaptive Randomization Trial of Passive Scattering Proton Therapy and Intensity-Modulated Photon Radiotherapy for Locally Advanced Non-Small-Cell Lung Cancer. J Clin Oncol:JCO2017740720. e-Pub 2018. PMID: 29293386.
- Kong FS, Moiseenko V, Zhao J, Milano MT, Li L, Rimner A, Das S, Li XA, Miften M, Liao Z, Martel M, Bentzen SM, Jackson A, Grimm J, Marks LB, Yorke E. Organs at risk considerations for thoracic stereotactic body radiation therapy: what is safe for lung parenchyma?. Int J Radiat Oncol Biol Phys S0360-3016(18):34014-8. e-Pub 2018. PMID: 30496880.
- Tang C, Lee WC, Reuben A, Chang L, Tran H, Little L, Gumbs C, Wargo J, Futreal A, Liao Z, Xia X, Yi X, Swisher SG, Heymach JV, Gomez D, Zhang J. Immune and circulating tumor DNA profiling following radiation treatment for oligometastatic NSCLC; translational correlatives from a mature randomized phase II trial. Int J Radiat Oncol Biol Phys. e-Pub 2019. PMID: 31678224.
- Moreno AC, Fellman B, Hobbs BP, Liao Z, Gomez DR, Chen A, Hahn SM, Chang JY, Lin SH. Biologically Effective Dose in Stereotactic Body Radiotherapy and Survival for Patients with Early-Stage Non-Small Cell Lung Cancer. J Thorac Oncol. e-Pub 2019. PMID: 31479748.
- Ma F, Guan Y, Yi Z, Chang L, Li Q, Chen S, Zhu W, Guan X, Li C, Qian H, Xia X, Yang L, Zhang J, Husain H, Liao Z, Futreal A, Huang J, Yi X, Xu B. Assessing tumor heterogeneity using ctDNA to predict and monitor therapeutic response in metastatic breast cancer. Int J Cancer. e-Pub 2019. PMID: 31241775.
- Niedzielski JS, Wei X, Xu T, Gomez DR, Liao Z, Bankson JA, Lai SY, Court LE, Yang J. Development and application of an elastic net logistic regression model to investigate the impact of cardiac substructure dose on radiation-induced pericardial effusion in patients with NSCLC. Acta Oncol:1-8. e-Pub 2020. PMID: 32678696.
- Milbury K, Li Y, Durrani S, Liao Z, Tsao AS, Carmack C, Cohen L, Bruera E. A Mindfulness-Based Intervention as a Supportive Care Strategy for Patients with Metastatic Non-Small Cell Lung Cancer and Their Spouses: Results of a Three-Arm Pilot Randomized Controlled Trial. Oncologist. e-Pub 2020. PMID: 32621630.
- Chapman BV, Ning MS, Farnia B, Mesko S, Lin SH, Tang C, Allen PK, Liao Z, Chang JY, Komaki R, Mehran RJ, Gandhi SJ, Gomez DR. Postoperative Radiotherapy for Locally Advanced NSCLC: Implications for Shifting to Conformal, High-Risk Fields. Clin Lung Cancer. e-Pub 2020. PMID: 32727706.
- Wang X, Palaskas NL, Yusuf SW, Abe JI, Lopez-Mattei J, Banchs J, Gladish GW, Lee P, Liao Z, Deswal A, Lin SH. Incidence and Onset of Severe Cardiac Events After Radiotherapy for Esophageal Cancer. J Thorac Oncol. e-Pub 2020. PMID: 32599073.
- Pasalic D, Lu Y, Betancourt-Cuellar SL, Taku N, Mesko SM, Bagley AF, Chance WW, Allen PK, Tang C, Antonoff MB, Balter PA, Mehran RJ, Welsh JW, Liao Z, Gomez D, Erasmus JJ, Nguyen QN. Stereotactic ablative radiation therapy for pulmonary metastases: Improving overall survival and identifying subgroups at high risk of local failure. Radiother Oncol 145:178-185. e-Pub 2020. PMID: 32044530.
Invited Articles
- Liao ZX, Gandhi S, Lin SH, Bradley J. Do Protons Offer Demonstrable Clinical Advantages for Thoracic Tumors?. Seminars in Radiation Oncology.
Abstracts
- Yang P, Liao Z, Gomez DR, Xu T, Levy LB, Deng W, Yang J, Mohan R. Prospective Study of Marginal Recurrence in Patients with Non-Small Cell Lung Cancer After Proton or Photon Chemoradiation Therapy. Int J Radiat Oncol Biol Phys 98(1):234, 2017. PMID: 28587001.
- Xu T, Xu Y, Huo J, Yang P, Gomez DR, Liao Z. Incidental Use of Beta-Blockers, Serum VEGF, and Their Association With Disease Outcome in Patients with Non-Small-Cell Lung Cancer Treated with Definitive Chemoradiation Therapy. Int J Radiat Oncol Biol Phys 98(1):245, 2017. PMID: 28587030.
- Deist TM, Yang P, Oberije C, Allen PK, van Wijk Y, Gomez DR, Xu T, Mohan R, Hahn SM, Lambin P, Liao Z. Dosimetric Analysis of Randomized Proton and Photon Plans with Respect to Radiation Toxicity: The Importance of High Dose Regions in Lung and Esophagus. Int J Radiat Oncol Biol Phys 98(1):246, 2017. PMID: 28587033.
- Lan M, Xu T, Gomez DR, Jeter MD, Nguyen QN, Deng W, Lin SH, Komaki RU, Liao Z. Association Between LGALS3 Gene Polymorphisms and Survival in Non-Small Cell Lung Cancer Patients Treated With Definitive Radiation Therapy. Int J Radiat Oncol Biol Phys 98(1):249-250, 2017. PMID: 28587040.
- Milbury K, Chaoul A, Engle R, Liao Z, Yang C, Carmack C, Shannon V, Spelman A, Wangyal T, Cohen L. Couple-based Tibetan yoga program for lung cancer patients and their caregivers. Psychooncology 24(1):117-20, 2015. e-Pub 2014. PMID: 24890852.
- Li H, Liu W, Park P, Matney J, Liao Z, Chang J, Zhang X, Li Y, Zhu RX. Evaluation of the systematic error in using 3D dose calculation in scanning beam proton therapy for lung cancer. J Appl Clin Med Phys 15(5):4810, 2014. e-Pub 2014. PMID: 25207565.
- Parker P, Cohen L, Chavez L, Baum G, Pisters KM, Liao Z, Mehran R. The association between provider characteristics and beliefs about psychosocial care in oncology.
- Hong J, Liao Z, Zhuang Y, Levy LB, Sheu T, Heymach JV, Nguyen QN, Xu T, Komaki R, Gomez DR. Prognostic factors as a function of disease-free interval after definitive (chemo)radiation for non-small cell lung cancer using conditional survival analysis. Am J Clin Oncol. e-Pub 2015. PMID: 26535988.
Book Chapters
- Schoenhals JE, Brooks ED, Cortez MA, Syedin SN, Niknam S, Wang Xiaohong, Cadena AP, Li XS, Gomez DR, Liao Z, and Welsh JW. Translational Research and Immunotherapy in Lung Cancer. In: Principles and Practice of Radiotherapy Techniques in Thoracic Malignancies. Springer International Publishing AG Switzerland, 255-296, 2016.
- Selek U, Bolukbasi Y, Topkan E, and Liao Z. Esophageal Cancer. In: Principles and Practice of Radiotherapy Techniques in Thoracic Malignancies. Springer International Publishing AG Switzerland, 297-324, 2016.
- Nguyen QN, Komaki R, Gomez D, Liao Z. Chest tumors (nsclc) - proton therapy in early-stage and advanced lung tumors. In: Contemporary Radiation Therapy. Atheneu: Brazil.